Explore: Trypsinogen

Trypsinogen (/ˌtrɪpˈsɪnədʒən, -ˌdʒɛn/) is the precursor form (or zymogen) of trypsin, a digestive enzyme. It is produced by the pancreas and found in

Measurement of immunoreactive trypsinogen (IRT) in blood of newborn babies is an assay in rapidly increasing use as a screening test for cystic fibrosis

holoenzyme) when the coenzyme binds. In the duodenum, the pancreatic zymogens, trypsinogen, chymotrypsinogen, proelastase and procarboxypeptidase, are converted

the others are trypsin-2 (anionic trypsinogen), and trypsin-3 (meso-trypsinogen). This gene encodes a trypsinogen, which is a member of the trypsin family

zymogens (or proenzymes) inside the pancreas, most notably trypsinogen. Normally, trypsinogen is converted to its active form (trypsin) in the first part

involved in digestion in humans and other animals. Enteropeptidase converts trypsinogen (a zymogen) into its active form trypsin, resulting in the subsequent

1996 that Whitcomb et al isolated the first responsible mutation in the trypsinogen gene (PRSS1) on the long arm of chromosome seven (7q35). The term "hereditary

Trypsin is formed in the small intestine when its proenzyme form, the trypsinogen produced by the pancreas, is activated. Trypsin cuts peptide chains mainly

and the active site is opened, can proteolysis occur. As can be seen, trypsinogen activation to trypsin is essential, because it activates its own reaction

activation of trypsinogen within the pancreas, leading to autodigestion. Involved genes may include trypsin 1, which codes for trypsinogen, SPINK1, which