Explore: Split Genes

wide variety of genes throughout organisms, bacteria, and viruses within all of the biological kingdoms. The fact that genes were split or interrupted

the split gene architecture of the eukaryotic genes started a new era of eukaryotic biology. The question of why eukaryotic genes had fragmented genes prompted

splicing of genes, in particular, has had a profound impact on the study and applications of molecular biology. The realisation that individual genes could

proponents because it meant that genes were very large and even huge genomes could not accommodate large numbers of genes. The proponents of junk DNA tended

  5. Discovery of split genes in animal genomes (1977)   6. Characterization of promoter elements of eukaryotic protein-coding genes and discovery of the

him but also pioneered the experiments that led to the discovery of split genes. Others also mentioned the exclusion of credit for Susan Berget, a then-postdoctoral

types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of RNA or protein from a gene), DNA is first copied

the split structure of eukaryotic genes. He developed the Shapiro & Senapathy algorithm (S&S) for predicting the splice sites in eukaryotic genes, which

microRNA Gene". RNA. 11 (8): 1245–57. doi:10.1261/rna.2890305. PMC 1370808. PMID 15987809. Sharp P.A. (June 2005). "The Discovery of Split Genes and RNA

eukaryotic genes. The algorithm employs a Position Weight Matrix (PWM) scoring formula to predict donor and acceptor splice sites in any given gene. This methodology