Explore: Prpsc Proteins

that can normally break down proteins. The normal form of the protein is called PrPC, while the infectious form is called PrPSc – the C refers to 'cellular'

abnormal folding of a protein known as a prion. Infectious prions are misfolded proteins that can cause normally folded proteins to also become misfolded

The protein can exist in multiple isoforms: the normal PrPC form, and the protease-resistant form designated PrPRes such as the disease-causing PrPSc (scrapie)

forms of prion are designated as PrPC, which is a normally folded protein, and PrPSc, a misfolded form which gives rise to the disease. The two forms do

achieved by applying immunohistochemistry of disease-associated prion protein (PrPSC) to tissues collected post mortem, including obex (a brainstem structure)

seeding process. Because the abnormal proteins stick to each other, and because PrP is continuously produced by cells, PrPSc accumulates in the brain, harming

normal brain prion protein (PrP) into the toxic, disease-related PrPSc form has started. At present, no way is known to detect PrPSc reliably except by

100 – fusion proteins, bcr-abl MeSH D12.776.624.664.500.320 – fusion proteins, gag-onc MeSH D12.776.624.664.500.320.700 – oncogene protein p65(gag-jun)

healthy proteins lose their normal structure and physiological functions (misfolding) and form fibrous deposits within and around cells. These protein misfolding

protein from diverse species. The newly generated protein exhibits the same biochemical, biological, and structural properties as brain-derived PrPSc