Explore: Polyketides

naturally occurring polyketides and evolution of new polyketides with novel or improved bioactivity. Naturally produced polyketides by various plants and

Polyketide synthases (PKSs) are a family of multi-domain enzymes or enzyme complexes that produce polyketides, a large class of secondary metabolites

also known as the polyketide pathway, is a fundamental biosynthetic route in organisms for the production of fatty acids and polyketides. This pathway operates

into four major classes: terpenes, phenylpropanoids (i.e. phenolics), polyketides, and alkaloids. Terpenes constitute a large class of natural products

class of aromatic polyketide antibiotics, also known as bacterial aromatic polyketides, produced by Streptomyces via type II polyketide synthases (PKSs)

Due to the similarity with polyketide synthases (PKS), many secondary metabolites are, in fact, fusions of NRPs and polyketides. In essence, this occurs

glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, and polyketides (derived from condensation of ketoacyl subunits); and sterol lipids and

chemotherapeutic drugs. In 2009, a study showed that O. unilateralis also produces polyketides. These secondary metabolites have been used in antibiotics such as patulin

thousands of specialized metabolites, including waxes, sterols, and polyketides. ATP citrate lyase is the primary enzyme responsible for the synthesis

either from type ll polyketide or shikimate pathways. This claim was not disputed until a key intermediate exclusive to the polyketide pathway was isolated