Explore: Genomic Instability

Genome instability (also genetic instability or genomic instability) refers to a high frequency of mutations within the genome of a cellular lineage. These

Chromosomal instability (CIN) is a type of genomic instability in which chromosomes are unstable, such that either whole chromosomes or parts of chromosomes

checkpoint, errors in mitosis, or DNA damage and operates to prevent genomic instability. It is a mechanism that is being researched as a potential therapeutic

for cruciform-binding proteins. Cruciform structures can increase genomic instability and are involved in the formation of various diseases, such as cancer

organism finds itself. These processes cause a great susceptibility to genomic instability in the parasite. This involves epistatic interactions between genes

short stature, predisposition to the development of cancer, and genomic instability. BS is caused by mutations in the BLM gene which is a member of the

of cells that were exposed to heavy ions compared to gamma rays. Genomic instability has been observed both in vitro and in vivo in the progeny of cells

relation to genetic instability". Cancer Res. 58 (5): 859–62. PMID 9500438. Eyfjord, JE; Bodvarsdottir, SK (2005). "Genomic instability and cancer: networks

glioblastoma cell lines reduced the occurrence of this genomic instability. Consequent of this genomic instability, the resulting cancer cells have the potential

WS, it has yet to be determined if it is the actual cause of the genomic instability observed in cells and the high rate of cancer in WS patients. Without