Explore: Gène Hr2

of a selection marker gene. "HR2" was then used to replace the marker by the "GOI. In the first ("knock-out"-) reaction the gene was tagged with a selectable

repeats (HR1 and HR2) following the fusion peptide at the N terminus of the protein. HR1 forms a parallel, trimeric coiled coil onto which HR2 region coils

regions, vr1, vr2, hr1, hr2, and vr3, on the surface glycoproteins. Binding specificity is determined primarily by the hr1 and hr2 regions, with the vr3

transmembrane (TM) domains crossing the OMM and a second cytosolic heptad-repeat (HR2) domain at the C-terminal. MFN2 has been shown by electron microscopy (EM)

membrane. S2 also contains two heptad repeat subdomains known as HR1 and HR2, sometimes called the "fusion core" region. These subdomains undergo dramatic

the membrane fusion of the virus to its potential cell host via the H1 and HR2, which are heptad repeat regions. Studies have shown that S1 domain induced

in virus fusion. It is believed that two heptad repeat regions (HR1) and (HR2) form a six-helix bundle structure that helps to induce fusion of the viral

export motif was added to the NpHR sequence. This modified NpHR (called eNpHR2.0) was utilized successfully to drive aggregate-free, high level expression

gp41 to penetrate the cell membrane. Repeat sequences in gp41, HR1, and HR2 then interact, causing the collapse of the extracellular portion of gp41

neuronal activity, e.g. halorhodopsin (NpHR), enhanced halorhodopsins (eNpHR2.0 and eNpHR3.0, see Figure 2), archaerhodopsin (Arch), fungal opsins (Mac)