Explore: Epitope Mapping

In immunology, epitope mapping is the process of experimentally identifying the binding site, or epitope, of an antibody on its target antigen (usually

T-cell epitopes. These vaccines can use multiple epitopes to increase their efficacy. To find epitopes to use for the vaccine, in silico mapping is often

epitope mapping. The procedure of identifying an antibody's binding sites (epitopes) on the target protein is referred to as "epitope mapping." Finding

sandwich configuration. Additionally, it allows the mapping of epitopes as antibodies of overlapping epitopes will be associated with an attenuated signal compared

In immunology, a linear epitope (also sequential epitope) is an epitope—a binding site on an antigen—that is recognized by antibodies by its linear sequence

related epitope and are "binned" together. Epitope binning is referenced in the literature under different names such as epitope mapping and epitope characterization

of applications. These include affinity-based screening, antibody epitope mapping, the identification of peptide substrates, the identification of cell-binding

These are known as linear epitopes. Antigen Linear epitope Epitope mapping, finding (on an antigen protein) the epitope(s) for a specific antibody Goldsby

In 2006, Moutaftsi et al. demonstrated that epitope-mapping tools could accurately identify the epitopes responsible for 95% of the murine T-cell response

PMC 4083010. PMID 24492943. Gao W, Xu Y, Liu J, Ho M (May 2016). "Epitope mapping by a Wnt-blocking antibody: evidence of the Wnt binding domain in heparan