Explore: Dermatan Sulfate

Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons,

their core disaccharide structures: Heparin/heparan sulfate (HSGAGs) Chondroitin sulfate/dermatan sulfate (CSGAGs) which along with HSGAGs are synthesized

"Chondroitin sulfate B" is an old name for dermatan sulfate, and it is no longer classified as a form of chondroitin sulfate. Chondroitin, without the "sulfate",

iduronate-2-sulfatase (I2S). The lack of this enzyme causes heparan sulfate and dermatan sulfate to accumulate in all body tissues. Hunter syndrome is the only

are bound to a collagen fibril, their dermatan sulfate chains may extend and associate with other dermatan sulfate chains on decorin that is bound to separate

distinguish N-sulfated polysaccharides such as heparin and HS from non N-sulfated polysaccharides such as chondroitin sulfate and dermatan sulfate, chondroitin

antithrombotic agent. Chondroitin sulfate shows slightly less biological activity than dermatan sulfate, and is composed of O-sulfated N-acetyl-D-galatosamine and

catalyses the hydrolysis of unsulfated α-L-iduronosidic linkages in dermatan sulfate. It is a glycoprotein enzyme found in the lysosomes of cells. It is

for breaking down GAGs. Without this enzyme, a buildup of dermatan sulfate and heparan sulfate occurs in the body. Symptoms appear during childhood, and

purified mixture of glycosaminoglycans composed of heparan sulfate (80%) and dermatan sulfate (20%). The low molecular weight of both sulodexide fractions