Explore: Connexins

gap junction protein system, where connexins are sorted by their α (GJA) and β (GJB) forms, with additional connexins grouped into the C, D and E groupings

significant sequence homology with connexins. Though differing in sequence to connexins, innexins are similar enough to connexins to form gap junctions in vivo

type of connexins are considered homomeric, while connexons made of differing types of connexins are heteromeric. The assembly of connexins destined

investigations involving the connexins demonstrated cells forming a direct connection with each other using groups of connexins but not connections with the

discrimination between channels formed by connexins and pannexins. Probenecid does not affect channels formed by connexins, but it inhibits pannexin-1 channels

PMID 9018031. Abrams CK, Rash JE (2009). "Connexins in the Nervous System". In Harris A, Locke D (eds.). Connexins. New York: Springer. pp. 323–57. doi:10

the GJA1 gene which encodes the connexin 43 protein. Further studies are needed to confirm or deny the role of connexin proteins in this disorder. Diagnosis

adjacent cells. Connexins span the plasma membrane 4 times, with amino- and carboxy-terminal regions facing the cytoplasm. Connexin genes are expressed

surrounding X-linked Charcot-Marie-Tooth disease are more prevalent. Connexins are membrane-spanning proteins that assemble to form gap junction channels

channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. The connexins are designated by their