Explore: Avermectins

[dubious – discuss] Together with the milbemycins, avermectins belong to IRAC group 6. Resistance to avermectins has been reported, which suggests moderation

(~20%). Out of all the avermectins, abamectin is the only one that is used both in agriculture and pharmaceuticals. Avermectins bind to the glutamate-gated

a 'without', vermis 'worms'). Of the various avermectins, Campbell's group found the compound "avermectin B1" to be the most potent when taken orally.

IRAC class 6. Milbemycin is effective against some avermectin-resistant insects. Like avermectins, milbemycins are products of fermentation by Streptomyces

Physiology or Medicine. He helped to discover a class of drugs called avermectins, whose derivatives have been shown to have "extraordinary efficacy" in

of circular chromosomes. Avermectins are industrially derived from the fermentation products of S. avermitilis. Avermectin itself was discovered by the

jointly with William C. Campbell for their role in the discovery of avermectins and ivermectin, the world's first endectocide and a safe and highly effective

receptors has been the therapeutic goal of anthelmintic therapy using avermectins. Avermectins target the alpha subunit of glutamate-gated chloride channels with

Avermectins belong to the family of macrocyclic lactones and are the major drugs used as in-feed treatments to kill sea lice. The first avermectin used

infestations. Emamectin, like other avermectins, is a hydrophobic 16-membered macrocyclic lactone. Emamectin differs from avermectins B1a and B1b by the presence