Explore: Acetylator Status (pharmacology)

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Source: The Open Library

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1The acetylator genesand drug response

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Book's cover

“The acetylator genesand drug response” Metadata:

  • Title: ➤  The acetylator genesand drug response
  • Author:
  • Language: English
  • Number of Pages: Median: 248
  • Publisher: Oxford University Press
  • Publish Date:

“The acetylator genesand drug response” Subjects and Themes:

Edition Identifiers:

Access and General Info:

  • First Year Published: 1987
  • Is Full Text Available: Yes
  • Is The Book Public: No
  • Access Status: Borrowable

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2The acetylator genes and drug response

By

Book's cover

“The acetylator genes and drug response” Metadata:

  • Title: ➤  The acetylator genes and drug response
  • Author:
  • Language: English
  • Number of Pages: Median: 248
  • Publisher: Oxford University Press
  • Publish Date:
  • Publish Location: New York

“The acetylator genes and drug response” Subjects and Themes:

Edition Identifiers:

Access and General Info:

  • First Year Published: 1987
  • Is Full Text Available: No
  • Is The Book Public: No
  • Access Status: No_ebook

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3Charakterisierung und vergleichende Untersuchungen zur Organspezifität verschiedener N-Acetyltransferasen der Ratte

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“Charakterisierung und vergleichende Untersuchungen zur Organspezifität verschiedener N-Acetyltransferasen der Ratte” Metadata:

  • Title: ➤  Charakterisierung und vergleichende Untersuchungen zur Organspezifität verschiedener N-Acetyltransferasen der Ratte
  • Author:
  • Language: ger
  • Number of Pages: Median: 141
  • Publisher: Minerva-Publikation
  • Publish Date:
  • Publish Location: München

“Charakterisierung und vergleichende Untersuchungen zur Organspezifität verschiedener N-Acetyltransferasen der Ratte” Subjects and Themes:

Edition Identifiers:

Access and General Info:

  • First Year Published: 1981
  • Is Full Text Available: No
  • Is The Book Public: No
  • Access Status: No_ebook

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Pharmacogenomics

response. Its name (pharmaco- + genomics) reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of a patient

Procainamide

phenotypes that result from the acetylation process, namely the slow and rapid acetylator. Procainamide can also be oxidized by the cytochrome P-450 to a reactive

Drug metabolism

group of people who acetylate slowly (slow acetylators) and those who acetylate quickly (rapid acetylators), split roughly 50:50 in the population of

N-acetyltransferase

deficient in hepatic N-acetyltransferase. This is known as a negative acetylator status. Drugs affected by this are: isoniazid procainamide hydralazine dapsone

4-Aminosalicylic acid

salicylazosulfapyridine therapy and the relation with drug metabolism and acetylator phenotype". The New England Journal of Medicine. 289 (10): 491–495. doi:10

Iproniazid

Reactions involving acetylation are influenced by genetic variance: the acetylator phenotype. The toxicological response to isoniazid (and thus iproniazid)

Isoniazid

than others. Hence, the half-life is bimodal, with "slow acetylators" and "fast acetylators". A graph of number of people versus time shows peaks at one

HIV disease–related drug reaction

among people with HIV. Some explanations involve poly-pharmacy, slow acetylator status, glutathione deficiency, etc. In addition, it is also thought to be