Downloads & Free Reading Options - Results

Organ-preservation is a recognised aim in the treatment of penile cancer, with a vision of maintaining penile form and function and optimising quality of life. We aimed to perform a systematic review of functional outcomes observed following oncoplastic surgery or radiotherapy as compared to organ-sacrificing surgery for penile cancer.

This article is from BMC Urology , volume 13 . Abstract Background: The nodal status is a strong predictor for cancer specific death in patients with penile carcinoma, and the C-reactive protein (CRP) level at diagnosis has recently been shown to be associated with poor clinical outcome in various solid malignancies. Therefore, this retrospective study was performed to evaluate the association between preoperative CRP levels and the incidence of nodal metastasis in patients with squamous cell carcinoma (SCC) of the penis. Methods: The analysis included 51 penile cancer patients who underwent either radical or partial penectomy for pT1-4 penile cancer between 1990 and 2010. The nodal status was correlated with patient and tumor specific characteristics. Results: Sixteen (31%) patients had lymph node metastasis at the time of penile cancer surgery. Nodal status was associated with tumor stage but did not correlate significantly with tumor grade. In contrast, high presurgical CRP levels were significantly associated with the diagnosis of nodal involvement (p = 0.04). The optimal CRP cut-off value to predict lymph node metastasis was set at 20 mg/l based on ROC analysis. Conclusions: Since a high preoperative serum CRP level was closely correlated with nodal disease, it could be used as an additional marker to help identify patients with penile cancer who may benefit from inguinal lymph node dissection.

dd

Penile Cancer Books

This article is from Radiation Oncology (London, England) , volume 9 . Abstract Purpose: To assess clinical outcomes of high-dose rate interstitial brachytherapy (HIB) in localized penile carcinoma. Material and methods: From 03/2006 to 08/2013, patients with biopsy-proven T1-T2 (

This article is from Radiation Oncology (London, England) , volume 9 . Abstract Purpose: To assess clinical outcomes of high-dose rate interstitial brachytherapy (HIB) in localized penile carcinoma. Material and methods: From 03/2006 to 08/2013, patients with biopsy-proven T1-T2 (

This article is from Journal of Medical Case Reports , volume 8 . Abstract Introduction: Epidermoid cysts represent common benign tumors occurring anywhere in the body but very rarely in the penis. Only a few cases of penile localization have been reported in the literature so far, most of them being congenital and/or idiopathic, usually presenting in children as slow-growing, solitary, well-delimited cystic lesions. Here, we describe the case of a patient with a penile epidermoid cyst presenting as an ulcerated lesion of the coronal sulcus, thus mimicking penile cancer. Case presentation: A 36-year-old Caucasian man presented with a three-month history of a rapidly growing asymptomatic ulcerated lesion in the ventral portion of the penile coronal sulcus. At surgical exploration, the area under the ulcerated lesion had a well-demarcated cystic shape; following its wide excision, an intraoperative histological examination revealed an epidermoid cyst. No recurrence had occurred at nine years of follow-up. Conclusions: Rare benign tumors of the penis, like the described epidermoid cyst, may mimic cancer. Nevertheless, penile ulcerated lesions should always be surgically explored as wide excision and intraoperative histological examination remain the only means of obtaining a precise disease definition and, consequently, administering the appropriate treatment.

"It all started with an itchy knob. Then ultra tight foreskin. Then he noticed a lump the size of a ""fat lentil"". Turns out, Jonathan Little had cancer of the willy, aka cancer of the ding dong, aka cancer of the weiner, aka Penile Cancer. Join the gang this week as they manage their very real phantom pains while Jonathan tells them the simultaneously horrifying yet hilarious breakdown of his experience of having this rare cancer. "

This article is from International Journal of Molecular Sciences , volume 14 . Abstract Penile cancer is a rare tumor. There is a limited understanding of the biological mediators of prognostic and therapeutic importance in penile cancer. However, there exists some fundamental understanding of the major pathways involved in the development of penile pre-neoplastic lesions and neoplasms. The aim of the present review is to highlight our current state of molecular knowledge in penile cancer to foster the necessary tools for researchers to pave major advancements in our current treatment paradigms and cancer specific outcomes.

No Description

No Description

This article is from Infectious Agents and Cancer , volume 8 . Abstract Background: Human papillomavirus (HPV) infection accounts for about 40-50% of all cases of penile carcinoma suggesting that other factors, including host genetic status, are involved in neoplastic transformation. In this perspective, STK11 gene, which has been found frequently mutated in HPV-related cervical carcinoma, has been analyzed in HPV-positive and HPV-negative invasive penile cancers to establish its mutational status and the possible correlation of HPV infection with specific genetic alterations. Methods: Genomic DNAs extracted from 26 cases of penile squamous cell carcinoma were analyzed for genetic alterations in the exons 1 to 9 of STK11 gene by quantitative real-time PCR. Ratios of potentially deleted and non-deleted exons were indicative of specific loss of STK11 coding regions. DNA samples of 5 cancer cases were subjected to standard PCR amplification of STK11 exons 1 to 9 and analyzed for somatic mutations by direct nucleotide sequencing analysis. Results: Heterozygous deletions of STK11 exon 1 and 2 were identified in 2 out of 14 HPV-positive (14.3%) and 1 out of 12 HPV-negative cases (8.3%). Complete nucleotide sequencing analysis of exons 1 to 9 showed a single nucleotide change upstream the exon 2 coding region in 1 out of 5 penile carcinoma samples. Conclusions: The present results suggest that single nucleotide mutations and/or deletions of STK11 gene are rare events in penile cancer. Moreover, no significant association was observed between STK11 alterations and HPV infection in these tumors.

This article is from Urology Annals , volume 4 . Abstract Aim:: To study the efficacy and safety of paclitaxel and platinum doublet chemotherapy in penile cancer patients with high-risk features of local failure. Materials and Methods:: Retrospective analysis was done of patients with 19 carcinoma of the penis who were offered adjuvant chemotherapy with paclitaxel and platinum combination. The data regarding the surgical details, high-risk features for which chemotherapy was offered, chemotherapy toxicity details (in accordance with CTCAE vs 3), failure pattern, and survival data were noted. SPSS version 16 was used for statistical analysis. Descriptive and Kaplan–Meier survival analysis was performed. Results:: Median age of patients was 48 years. Fifteen patients received paclitaxel in combination with cisplatin and four received paclitaxel with carboplatin in view of their low serum creatinine clearance. The treatment was completed by 12 patients (63.2%). Of 79 planned cycles, 50 were taken. The treatment was well tolerated with grade 3-4 gastrointestinal toxicity was seen in 1 patient, grade 3 neurological toxicity in one and grade 5 neutropenia in one patient. Treatment related death occured in one patient. The median follow-up was 15.33 months and 6 loco-regional relapsed had taken place. The estimated median DFS was 16.2 months and the estimated median OS was not reached. The estimated DFS for treatment completed patients was 23.13 months as against 2.16 months for patients not completing treatment. Conclusion:: The platinum and taxane doublet chemotherapy was found to be safe and effective.

There is wide variability in sexual potency rates (9-86%) after prostate cancer surgery due to our limited understanding of the location of the cavernous nerves, which are responsible for erectile function. Advances in identification and preservation of these nerves would result in improved postoperative potency and patient quality of life. We hypothesize that application of three optical technologies for identification, imaging, and preservation of the nerves during prostate surgery will result in improved sexual function: (1) Laser nerve stimulation for identification, optical coherence tomography (OCT) for nerve imaging, and (3) precise laser prostate dissection for nerve preservation. Year 1 was devoted to optimization of laser stimulation parameters and comparison with electrical stimulation. We completed these tasks and then started on Year 2 aims, including assembly of a laparoscopic laser nerve stimulation probe, and improving OCT image quality for differentiating nerves and prostate. We have published our results (2 manuscripts, 5 conference proceedings, and 3 abstracts).

This article is from Chinese Journal of Cancer , volume 33 . Abstract Using a population-based cancer registry, Thuret et al. developed 3 nomograms for estimating cancer-specific mortality in men with penile squamous cell carcinoma. In the initial cohort, only 23.0% of the patients were treated with inguinal lymphadenectomy and had pN stage. To generalize the prediction models in clinical practice, we evaluated the performance of the 3 nomograms in a series of penile cancer patients who were treated with definitive surgery. Clinicopathologic information was obtained from 160 M0 penile cancer patients who underwent primary tumor excision and regional lymphadenectomy between 1990 and 2008. The predicted probabilities of cancer-specific mortality were calculated from 3 nomograms that were based on different disease stage definitions and tumor grade. Discrimination, calibration, and clinical usefulness were assessed to compare model performance. The discrimination ability was similar in nomograms using the TNM classification or American Joint Committee on Cancer staging (Harrell's concordance index = 0.817 and 0.832, respectively), whereas it was inferior for the Surveillance, Epidemiology and End Results staging (Harrell's concordance index = 0.728). Better agreement with the observed cancer-specific mortality was shown for the model consisting of TNM classification and tumor grade, which also achieved favorable clinical net benefit, with a threshold probability in the range of 0 to 42%. The nomogram consisting of TNM classification and tumor grading was shown to have better performance for predicting cancer-specific mortality in penile cancer patients who underwent definitive surgery. Our data support the integration of this model in decision-making and trial design.

This article is from Indian Journal of Palliative Care , volume 20 . Abstract Penile metastasis secondary to primary bladder cancer is a rare entity and represents a challenging problem. The common mode of spread to the penis is by retrograde venous route. The overall outcome is dismal and most patients will die within 1 year even after optimum treatment. Here, we report two such cases.

This article is from Journal of Translational Medicine , volume 11 . Abstract Background: Penile cancer (PC) is a rare tumor, and therapeutic options are limited for this disease, with an overall 5-year overall survival around 65-70%. Adjuvant therapy is not recommended for patients with N0-1 disease, despite up to 60% of these patients will die within 5 years from diagnosis. Methods: Medical records of all patients who underwent radical surgery at University Federico II of Naples and at National Tumor Institute “Pascale” of Naples for early squamous cell carcinoma of the penis from January, 2000 to December, 2011 were retrieved. Paraffin wax embedded tissue specimens were retrieved from the pathology archives of the participating Institutions for all patients. Expression of p-EGFR, EGFR and positivity to HPV were evaluated along with other histological variables of interest. Demographic data of eligible patients were retrieved along with clinical characteristics such as type of surgical operation, time of follow up, time of recurrence, overall survival. A multivariable model was constructed using a forward stepwise selection procedure. Results: Thirty eligible patients were identified. All patients were positive for EGFR by immunohistochemistry, while 13 and 16 were respectively positive for nuclear and cytosolic p-EGFR. No EGFR amplification was detected by FISH. Eight patients were positive for high-risk HPV by ISH. On univariable analysis, corpora cavernosa infiltration (OR 7.8; 95% CI = 0,8 to 75,6; P = 0,039) and positivity for cytosolic p-EGFR (OR 7.6; 95% CI =1.49 to 50; P = 0.009) were predictive for recurrence, while only positivity for cytosolic p-EGFR (HR =9.0; 95% CI 1.0-100; P = 0,0116) was prognostic for poor survival. Conclusion: It is of primary importance to identify patients with N0-1 disease who are at increased risk of recurrence, as they do not normally receive any adjuvant therapy. Expression of p-EGFR was found in this series to be strongly related to increase risk of recurrence and shorter overall survival. This finding is consistent with the role of p-EGFR in other solid malignancies. Integration of p-EGFR with classic prognostic factors and other histology markers should be pursued to establish optimal adjuvant therapy for N0-1 PC patients.

There is wide variability in sexual potency rates (9-86%) after prostate cancer surgery due to a limited understanding of the location of the cavernous nerves, which are responsible for erectile function. Advances in identification and preservation of these nerves would result in improved postoperative potency and patient quality of life. We hypothesize that application of 3 optical technologies for identification, imaging, and preservation of the nerves during prostate surgery will result in improved sexual function: (1) Laser nerve stimulation for identification, (2) optical coherence tomography (OCT) for nerve imaging, and (3) precise laser prostate dissection for nerve preservation. In Year 2, we continued development and testing of the laser nerve stimulation probe, measured the near-infrared optical properties of the prostate for optimization of OCT imaging, and combined 3 image processing algorithms for improving image quality of OCT prostate images. This work resulted in the publication of 2 manuscripts, 5 conference proceedings, and 1 abstract.

There is wide variability in sexual potency rates (9-86%) after prostate cancer surgery due to a limited understanding of the location of the cavernous nerves, which are responsible for erectile function. Advances in identification and preservation of these nerves would result in improved postoperative potency and patient quality of life. We hypothesize that application of 3 optical technologies for identification, imaging, and preservation of the nerves during prostate surgery will result in improved sexual function: (1) Laser nerve stimulation for identification, (2) optical coherence tomography (OCT) for nerve imaging, and (3) precise laser prostate dissection for nerve preservation. In Year 3, we compared time domain and fourier-domain OCT for prostate imaging. We also developed a new approach to stimulation of prostate nerves using continuous-wave laser radiation, a new laser wavelength, and an all-single-mode fiber system, which resulted in faster stimulation and a more compact, less expensive system. We published 2 manuscripts and 3 conference proceedings on this work.