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Bayesian Networks by Marco Scutari

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1Learning Bayesian Networks With Incomplete Data By Augmentation

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We present new algorithms for learning Bayesian networks from data with missing values using a data augmentation approach. An exact Bayesian network learning algorithm is obtained by recasting the problem into a standard Bayesian network learning problem without missing data. To the best of our knowledge, this is the first exact algorithm for this problem. As expected, the exact algorithm does not scale to large domains. We build on the exact method to create an approximate algorithm using a hill-climbing technique. This algorithm scales to large domains so long as a suitable standard structure learning method for complete data is available. We perform a wide range of experiments to demonstrate the benefits of learning Bayesian networks with such new approach.

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2Bayesian Model Selection For The Latent Position Cluster Model For Social Networks

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The latent position cluster model is a popular model for the statistical analysis of network data. This model assumes that there is an underlying latent space in which the actors follow a finite mixture distribution. Moreover, actors which are close in this latent space are more likely to be tied by an edge. This is an appealing approach since it allows the model to cluster actors which consequently provides the practitioner with useful qualitative information. However, exploring the uncertainty in the number of underlying latent components in the mixture distribution is a complex task. The current state-of-the-art is to use an approximate form of BIC for this purpose, where an approximation of the log-likelihood is used instead of the true log-likelihood which is unavailable. The main contribution of this paper is to show that through the use of conjugate prior distributions it is possible to analytically integrate out almost all of the model parameters, leaving a posterior distribution which depends on the allocation vector of the mixture model. This enables posterior inference over the number of components in the latent mixture distribution without using trans- dimensional MCMC algorithms such as reversible jump MCMC. Our approach is compared with the state-of-the-art latentnet (Krivitsky & Handcock 2015) and VBLPCM (Salter-Townshend & Murphy 2013) packages.

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3DTIC ADA429677: Applying Bayesian Belief Networks In Sun Tzu's Art Of War

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The principles of Sun Tzu's Art of War have been widely used by business executives and military officers with much success in the realm of competition and conflict. However, when conflict situations arise in a highly stressful environment coupled with the pressure of time, decision makers may not be able to consider all the key concepts when forming their decisions or strategies. Therefore, a structured reasoning approach may be used to apply Sun Tzu's principles correctly and fully. It is believed that Sun Tzu's principles can be modeled mathematically; hence, a Bayesian Network Model (a form of mathematical tool using probability theory) is used to capture Sun Tzu's principles and provide a structured reasoning approach. Scholars have identified incompleteness in Sun Tzu's appreciation of information in war and his application of secret agents. This incompleteness results in circular reasoning when both sides of the conflict apply his principles. This circular reasoning can be resolved through the use of advanced probability theory. A Bayesian Network Model not only provides a structured reasoning approach, but more importantly, it also can resolve the circular reasoning problem that has been identified.

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4DTIC ADA339011: Application Of Bayesian Networks To Midcourse Multi-Target Tracking

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This presentation discusses the application of Bayesian Networks or Influence Diagrams to the implementation of midcourse tracking algorithms. The Influence Diagram is used to represent and manipulate probabilistic information in complex networks of random variables. The generic capabilities of the Influence Diagram are used to carry out eh major tracking functions, including linear gaussian state estimation, data association hypothesis scoring and track promotion scoring.

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5NASA Technical Reports Server (NTRS) 20110014231: Diagnosing Intermittent And Persistent Faults Using Static Bayesian Networks

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Both intermittent and persistent faults may occur in a wide range of systems. We present in this paper the introduction of intermittent fault handling techniques into ProDiagnose, an algorithm that previously only handled persistent faults. We discuss novel algorithmic techniques as well as how our static Bayesian networks help diagnose, in an integrated manner, a range of intermittent and persistent faults. Through experiments with data from the ADAPT electrical power system test bed, generated as part of the Second International Diagnostic Competition (DXC-10), we show that this novel variant of ProDiagnose diagnoses intermittent faults accurately and quickly, while maintaining strong performance on persistent faults.

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6NASA Technical Reports Server (NTRS) 20120015511: Object-Oriented Bayesian Networks (OOBN) For Aviation Accident Modeling And Technology Portfolio Impact Assessment

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The concern for reducing aviation safety risk is rising as the National Airspace System in the United States transforms to the Next Generation Air Transportation System (NextGen). The NASA Aviation Safety Program is committed to developing an effective aviation safety technology portfolio to meet the challenges of this transformation and to mitigate relevant safety risks. The paper focuses on the reasoning of selecting Object-Oriented Bayesian Networks (OOBN) as the technique and commercial software for the accident modeling and portfolio assessment. To illustrate the benefits of OOBN in a large and complex aviation accident model, the in-flight Loss-of-Control Accident Framework (LOCAF) constructed as an influence diagram is presented. An OOBN approach not only simplifies construction and maintenance of complex causal networks for the modelers, but also offers a well-organized hierarchical network that is easier for decision makers to exploit the model examining the effectiveness of risk mitigation strategies through technology insertions.

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7Bayesian Design Of Tandem Networks For Distributed Detection With Multi-bit Sensor Decisions

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We consider the problem of decentralized hypothesis testing under communication constraints in a topology where several peripheral nodes are arranged in tandem. Each node receives an observation and transmits a message to its successor, and the last node then decides which hypothesis is true. We assume that the observations at different nodes are, conditioned on the true hypothesis, independent and the channel between any two successive nodes is considered error-free but rate-constrained. We propose a cyclic numerical design algorithm for the design of nodes using a person-by-person methodology with the minimum expected error probability as a design criterion, where the number of communicated messages is not necessarily equal to the number of hypotheses. The number of peripheral nodes in the proposed method is in principle arbitrary and the information rate constraints are satisfied by quantizing the input of each node. The performance of the proposed method for different information rate constraints, in a binary hypothesis test, is compared to the optimum rate-one solution due to Swaszek and a method proposed by Cover, and it is shown numerically that increasing the channel rate can significantly enhance the performance of the tandem network. Simulation results for $M$-ary hypothesis tests also show that by increasing the channel rates the performance of the tandem network significantly improves.

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8Measuring Adverse Drug Effects On Multimorbity Using Tractable Bayesian Networks

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Managing patients with multimorbidity often results in polypharmacy: the prescription of multiple drugs. However, the long-term effects of specific combinations of drugs and diseases are typically unknown. In particular, drugs prescribed for one condition may result in adverse effects for the other. To investigate which types of drugs may affect the further progression of multimorbidity, we query models of diseases and prescriptions that are learned from primary care data. State-of-the-art tractable Bayesian network representations, on which such complex queries can be computed efficiently, are employed for these large medical networks. Our results confirm that prescriptions may lead to unintended negative consequences in further development of multimorbidity in cardiovascular diseases. Moreover, a drug treatment for one disease group may affect diseases of another group.

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9A Bayesian Networks Approach To Operational Risk

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A system for Operational Risk management based on the computational paradigm of Bayesian Networks is presented. The algorithm allows the construction of a Bayesian Network targeted for each bank using only internal loss data, and takes into account in a simple and realistic way the correlations among different processes of the bank. The internal losses are averaged over a variable time horizon, so that the correlations at different times are removed, while the correlations at the same time are kept: the averaged losses are thus suitable to perform the learning of the network topology and parameters. The algorithm has been validated on synthetic time series. It should be stressed that the practical implementation of the proposed algorithm has a small impact on the organizational structure of a bank and requires an investment in human resources limited to the computational area.

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10Estimating Regional Effects Of Climate Change And Altered Land Use On Biosphere Carbon Fluxes Using Distributed Time Delay Neural Networks With Bayesian Regularized Learning

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The ability to accurately predict changes of the carbon and energy balance on a regional scale is of great importance for assessing the effect of land use changes on carbon sequestration under future climate conditions. Here, a suite of land cover-specific Distributed Time Delay Neural Networks with a parameter adoption algorithm optimized through Bayesian regularization was used to model the statewide atmospheric exchange of CO 2 , water vapor, and energy in Oregon with its strong spatial gradients of climate and land cover. The network models were trained with eddy covariance data from 9 atmospheric flux towers. Compared to results derived with more common regression networks utilizing non-delayed input vectors, the performance of the DTDNN models was significantly improved with an average increase of the coefficients of determination of 64%. The optimized models were applied in combination with downscaled climate projections of the CMIP5 project to calculate future changes in the cycle of carbon, associated with a prescribed conversion of conventional grass-crops to hybrid poplar plantations for biofuel production in Oregon. The results show that under future RCP8.5 climate conditions the total statewide NEP increases by 0.87 TgC per decade until 2050 without any land use changes. With all non-forage grass completely converted to hybrid poplar the NEP averages 32.9 TgC in 2046–2050, an increase of 9%. Through comparisons with the results of a Bayesians inversion study, the results presented demonstrate that DTDNN models are a specifically well-suited approach to use the available data from flux networks to assess changes in biosphere–atmosphere exchange triggered by massive land use conversion superimposed on a changing climate.

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11Analysis Of Maternal Deaths In Oaxaca Through Bayesian Networks

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Maternal mortality has shown a considerable decrease in countries where the rate of development is higher. This is not the case for Mexico where a large number of annual maternal deaths are still perceived, which turns out to be a public health problem in which the World Health Organization (WHO) considers indigenous populations with a higher rate of maternal deaths, as is the case in the state of Oaxaca. The aim of this paper is to carry out an analysis of maternal deaths during the period 2014-2016 in the municipalities of this state in order to identify the main causes that cause it, factors that intervene in it and municipalities with the highest rate of this problem. The analysis has revealed that the National Institute of Social Security (IMSS) is the site where the highest number of deaths occurred, as well as identifying the main causes that lead to maternal mortality, determining that it is not enough to have Public and Private Health institutions, but they must have a better care system and equipment for care, without leaving aside the cultural aspect of the inhabitants of the municipalities of the state of Oaxaca. Araceli Pinacho-Ríos | Guillermo De la Torre-Gea"Analysis of Maternal Deaths in Oaxaca through Bayesian Networks" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-2 , February 2018, URL: http://www.ijtsrd.com/papers/ijtsrd10758.pdf  http://www.ijtsrd.com/computer-science/data-miining/10758/analysis-of-maternal-deaths-in-oaxaca-through-bayesian-networks/araceli-pinacho-ríos

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12Exploiting Causality For Selective Belief Filtering In Dynamic Bayesian Networks

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Dynamic Bayesian networks (DBNs) are a general model for stochastic processes with partially observed states. Belief filtering in DBNs is the task of inferring the belief state (i.e. the probability distribution over process states) based on incomplete and noisy observations. This can be a hard problem in complex processes with large state spaces. In this article, we explore the idea of accelerating the filtering task by automatically exploiting causality in the process. We consider a specific type of causal relation, called passivity, which pertains to how state variables cause changes in other variables. We present the Passivity-based Selective Belief Filtering (PSBF) method, which maintains a factored belief representation and exploits passivity to perform selective updates over the belief factors. PSBF produces exact belief states under certain assumptions and approximate belief states otherwise, where the approximation error is bounded by the degree of uncertainty in the process. We show empirically, in synthetic processes with varying sizes and degrees of passivity, that PSBF is faster than several alternative methods while achieving competitive accuracy. Furthermore, we demonstrate how passivity occurs naturally in a complex system such as a multi-robot warehouse, and how PSBF can exploit this to accelerate the filtering task.

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13Bayesian Inference Of Natural Rankings In Incomplete Competition Networks.

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This article is from Scientific Reports , volume 4 . Abstract Competition between a complex system's constituents and a corresponding reward mechanism based on it have profound influence on the functioning, stability, and evolution of the system. But determining the dominance hierarchy or ranking among the constituent parts from the strongest to the weakest – essential in determining reward and penalty – is frequently an ambiguous task due to the incomplete (partially filled) nature of competition networks. Here we introduce the “Natural Ranking,” an unambiguous ranking method applicable to a round robin tournament, and formulate an analytical model based on the Bayesian formula for inferring the expected mean and error of the natural ranking of nodes from an incomplete network. We investigate its potential and uses in resolving important issues of ranking by applying it to real-world competition networks.

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14Perception Of Security In Mexico Through Bayesian Networks

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The present investigation shows an analysis of the perception of security by the population, using the Bayes probabilistic method, based on open data from the Survey of Victimization and Perception of Public Safety (ENVIPE). Through a Bayesian network composed of variables that are mostly interrelated, coupled with probabilistic inferences that in turn project on others, with the purpose of analyzing their probabilistic behaviors by originating actions that should be considered as preventive measures in the face of insecurity. As a result of this study, people who have home surveillance systems installed as a preventive measure, choose to change their residence, which means that this security measure has not contributed to the reduction of crime. On the other hand, most of the probabilities analyzed depend on the locality specifically since, in turn, these consist of different criminal indices. Applying the probabilistic analysis, it allowed comparing the results with current information, being coherent with the indexes issued by the different national and international organisms in relation to public security. Carlos Ramírez | Guillermo De la Torre-Gea"Perception of Security in Mexico through Bayesian Networks" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-2 , February 2018, URL: http://www.ijtsrd.com/papers/ijtsrd10702.pdf Article URL: http://www.ijtsrd.com/other-scientific-research-area/other/10702/perception-of-security-in-mexico-through-bayesian-networks/carlos-ramírez

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15Python Environment For Bayesian Learning: Inferring The Structure Of Bayesian Networks From Knowledge And Data(Machine Learning Open Source Software Paper)

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The present investigation shows an analysis of the perception of security by the population, using the Bayes probabilistic method, based on open data from the Survey of Victimization and Perception of Public Safety (ENVIPE). Through a Bayesian network composed of variables that are mostly interrelated, coupled with probabilistic inferences that in turn project on others, with the purpose of analyzing their probabilistic behaviors by originating actions that should be considered as preventive measures in the face of insecurity. As a result of this study, people who have home surveillance systems installed as a preventive measure, choose to change their residence, which means that this security measure has not contributed to the reduction of crime. On the other hand, most of the probabilities analyzed depend on the locality specifically since, in turn, these consist of different criminal indices. Applying the probabilistic analysis, it allowed comparing the results with current information, being coherent with the indexes issued by the different national and international organisms in relation to public security. Carlos Ramírez | Guillermo De la Torre-Gea"Perception of Security in Mexico through Bayesian Networks" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-2 , February 2018, URL: http://www.ijtsrd.com/papers/ijtsrd10702.pdf Article URL: http://www.ijtsrd.com/other-scientific-research-area/other/10702/perception-of-security-in-mexico-through-bayesian-networks/carlos-ramírez

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16Identification Of Recurrent Neural Networks By Bayesian Interrogation Techniques

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The present investigation shows an analysis of the perception of security by the population, using the Bayes probabilistic method, based on open data from the Survey of Victimization and Perception of Public Safety (ENVIPE). Through a Bayesian network composed of variables that are mostly interrelated, coupled with probabilistic inferences that in turn project on others, with the purpose of analyzing their probabilistic behaviors by originating actions that should be considered as preventive measures in the face of insecurity. As a result of this study, people who have home surveillance systems installed as a preventive measure, choose to change their residence, which means that this security measure has not contributed to the reduction of crime. On the other hand, most of the probabilities analyzed depend on the locality specifically since, in turn, these consist of different criminal indices. Applying the probabilistic analysis, it allowed comparing the results with current information, being coherent with the indexes issued by the different national and international organisms in relation to public security. Carlos Ramírez | Guillermo De la Torre-Gea"Perception of Security in Mexico through Bayesian Networks" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-2 , February 2018, URL: http://www.ijtsrd.com/papers/ijtsrd10702.pdf Article URL: http://www.ijtsrd.com/other-scientific-research-area/other/10702/perception-of-security-in-mexico-through-bayesian-networks/carlos-ramírez

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17Relational Dynamic Bayesian Networks

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Stochastic processes that involve the creation of objects and relations over time are widespread, but relatively poorly studied. For example, accurate fault diagnosis in factory assembly processes requires inferring the probabilities of erroneous assembly operations, but doing this efficiently and accurately is difficult. Modeled as dynamic Bayesian networks, these processes have discrete variables with very large domains and extremely high dimensionality. In this paper, we introduce relational dynamic Bayesian networks (RDBNs), which are an extension of dynamic Bayesian networks (DBNs) to first-order logic. RDBNs are a generalization of dynamic probabilistic relational models (DPRMs), which we had proposed in our previous work to model dynamic uncertain domains. We first extend the Rao-Blackwellised particle filtering described in our earlier work to RDBNs. Next, we lift the assumptions associated with Rao-Blackwellization in RDBNs and propose two new forms of particle filtering. The first one uses abstraction hierarchies over the predicates to smooth the particle filters estimates. The second employs kernel density estimation with a kernel function specifically designed for relational domains. Experiments show these two methods greatly outperform standard particle filtering on the task of assembly plan execution monitoring.

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  • Title: ➤  Relational Dynamic Bayesian Networks
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18Efficient Computational Strategies For Doubly Intractable Problems With Applications To Bayesian Social Networks

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Powerful ideas recently appeared in the literature are adjusted and combined to design improved samplers for Bayesian exponential random graph models. Different forms of adaptive Metropolis-Hastings proposals (vertical, horizontal and rectangular) are tested and combined with the Delayed rejection (DR) strategy with the aim of reducing the variance of the resulting Markov chain Monte Carlo estimators for a given computational time. In the examples treated in this paper the best combination, namely horizontal adaptation with delayed rejection, leads to a variance reduction that varies between 92% and 144% relative to the adaptive direction sampling approximate exchange algorithm of Caimo and Friel (2011). These results correspond to an increased performance which varies from 10% to 94% if we take simulation time into account. The highest improvements are obtained when highly correlated posterior distributions are considered.

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19A Bayesian Framework For Distributed Estimation Of Arrival Rates In Asynchronous Networks

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In this paper we consider a network of agents monitoring a spatially distributed arrival process. Each node measures the number of arrivals seen at its monitoring point in a given time-interval with the objective of estimating the unknown local arrival rate. We propose an asynchronous distributed approach based on a Bayesian model with unknown hyperparameter, where each node computes the minimum mean square error (MMSE) estimator of its local arrival rate in a distributed way. As a result, the estimation at each node "optimally" fuses the information from the whole network through a distributed optimization algorithm. Moreover, we propose an ad-hoc distributed estimator, based on a consensus algorithm for time-varying and directed graphs, which exhibits reduced complexity and exponential convergence. We analyze the performance of the proposed distributed estimators, showing that they: (i) are reliable even in presence of limited local data, and (ii) improve the estimation accuracy compared to the purely decentralized setup. Finally, we provide a statistical characterization of the proposed estimators. In particular, for the ad-hoc estimator, we show that as the number of nodes goes to infinity its mean square error converges to the optimal one. Numerical Monte Carlo simulations confirm the theoretical characterization and highlight the appealing performances of the estimators.

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20DTIC ADA570255: Using Machine-Learned Bayesian Belief Networks To Predict Perioperative Risk Of Clostridium Difficile Infection Following Colon Surgery

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Background: Clostridium difficile (C-Diff) infection following colorectal resection is an increasing source of morbidity and mortality. Objective: We sought to determine if machine-learned Bayesian belief networks (ml-BBNs) could preoperatively provide clinicians with postoperative estimates of C-Diff risk. Methods: We performed a retrospective modeling of the Nationwide Inpatient Sample (NIS) national registry dataset with independent set validation. The NIS registries for 2005 and 2006 were used for initial model training, and the data from 2007 were used for testing and validation. International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM)codes were used to identify subjects undergoing colon resection and postoperative C-Diff development. The ml-BBNs were trained using a stepwise process. Receiver operating characteristic (ROC) curve analysis was conducted and area under the curve (AUC), positive predictive value (PPV), and negative predictive value (NPV) were calculated. Results: From over 24 million admissions, 170,363 undergoing colon resection met the inclusion criteria. Overall, 1.7% developed postoperative C-Diff. Using the ml-BBN to estimate C-Diff risk, model AUC is 0.75. Using only known a priori features, AUC is 0.74. The model has two configurations: a high sensitivity and a high specificity configuration. Sensitivity, specificity, PPV,and NPV are 81.0%, 50.1%, 2.6%, and 99.4% for high sensitivity and 55.4%, 81.3%, 3.5%, and 99.1% for high specificity. C-Diff has 4 first-degree associates that influence the probability of C-Diff development: weight loss, tumor metastases,inflammation/infections, and disease severity. Conclusions: Machine-learned BBNs can produce robust estimates of postoperative C-Diff infection, allowing clinicians to identify high-risk patients and potentially implement measures to reduce its incidence or morbidity.

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21DTIC ADA488405: Bayesian Mixed-Membership Models Of Complex And Evolving Networks

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This thesis provides a methodological framework for the statistical analysis of complex graphs and dynamic networks.1 In it, I develop probabilistic algorithms that generate, evolve and integrate a heterogeneous collection of graphs, I study the statistical models these algorithms implicitly specify, and I develop strategies for estimating the set of quantities on which they depend in the context of applications to social and biological networks.

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22DTIC ADA587480: Multi-Entity Bayesian Networks Learning In Predictive Situation Awareness

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Over the past two decades, machine learning has led to substantial changes in Data Fusion Systems globally. One of the most important application areas for data fusion is situation awareness to support command and control. Situation awareness is perception of elements in the environment, comprehension of the current situation, and projection of future status before decision making. Traditional fusion systems focus on lower levels of the JDL hierarchy, leaving higher-level fusion and situation awareness largely to unaided human judgment. This becomes untenable in today's increasingly data-rich environments, characterized by information and cognitive overload. Higher-level fusion to support situation awareness requires semantically rich representations amenable to automated processing. Ontologies are an essential tool for representing domain semantics and expressing information about entities and relationships in the domain. Probabilistic ontologies augment standard ontologies with support for uncertainty management, which is essential for higher-level fusion to support situation awareness. PROGNOS is a prototype Predictive Situation Awareness (PSAW) System for the maritime domain. The core logic for the PROGNOS probabilistic ontologies is Multi-Entity Bayesian Networks (MEBN), which combine First-Order Logic with Bayesian Networks for representing and reasoning about uncertainty in complex, knowledge-rich domains. MEBN goes beyond standard Bayesian networks to enable reasoning about an unknown number of entities interacting with each other in various types of relationships, a key requirement for PSAW. The existing probabilistic ontology for PROGNOS was constructed manually by a domain expert. However, manual MEBN modeling is labor-intensive and not agile. We have developed a learning algorithm for MEBN-based probabilistic ontologies. This paper presents a bridge between MEBN and the Relational Model, and a parameter and structure learning algorithm for MEBN.

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23DTIC ADA608777: Dynamic Bayesian Networks As A Probabilistic Metamodel For Combat Simulations

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Simulation modeling is used in many situations. Simulation meta-modeling is used to estimate a simulation model result by representing the space of simulation model responses. Metamodeling methods are particularly useful when the simulation model is not particularly suited to real-time or mean real-time use. Most metamodeling methods provide expected value responses while some situations need probabilistic responses. This research establishes the viability of Dynamic Bayesian Networks for simulation metamodeling, those situations needing probabilistic responses. A bootstrapping method is introduced to reduce simulation data requirement for a DBN, and experimental design is shown to benefit a DBN used to represent a multi-dimensional response space. An improved interpolation method is developed and shown beneficial to DBN metamodeling applications. These contributions are employed in a military modeling case study to fully demonstrate the viability of DBN metamodeling for Defense analysis application.

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24Enhancing Reliability In Photonuclear Cross-Section Fitting With Bayesian Neural Networks

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Enhancing Reliability in Photonuclear Cross-Section Fitting with Bayesian Neural Networks 作者: Qian-KunSun 1,2 YueZhang 3 Zi-RuiHao 3 Hong-WeiWang 1,2,3 Gong-TaoFan 1,2,3 Hang-HuaXu 3 Long-XiangLiu 3 ShengJin 1,2 Yu-XuanYang 1,4 Kai-JieChen 1,5 Zhen-WeiWang 1,2 作者单位: 1. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China 2. University of Chinese Academy of Sciences, Beijing 100049, China 3. Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China 4. School of Physics and Microelectronics, Zhengzhou university, Zhengzhou 450001, China 5. School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China 通讯作者: Qian-KunSun Email:[email protected] YueZhang Email:[email protected] Hong-WeiWang Email:[email protected] 提交时间: 2024-11-19 12:05:40 摘要: This study investigates photonuclear reaction $(\gamma,n)$ cross-sections using Bayesian neural network (BNN) analysis. After determining the optimal network architecture, which features two hidden layers, each with 50 hidden nodes, training was conducted for 30,000 iterations to ensure comprehensive data capture. By analyzing the distribution of absolute errors positively correlated with the cross-section for the isotope $^{159}$Tb, as well as the relative errors unrelated to the cross-section, we confirmed that the network effectively captured the data features without overfitting. Comparison with the TENDL-2021 Database demonstrated the BNN’s reliability in fitting photonuclear cross-sections with lower average errors. The predictions for nuclei with single and double giant dipole resonance peak cross-sections, the accurate determination of the photoneutron reaction threshold in the low-energy region, and the precise description of trends in the high-energy cross-sections further demonstrate the network’s generalization ability on the validation set. This can be attributed to the consistency of the training data. By using consistent training sets from different laboratories, Bayesian neural networks can predict nearby unknown cross-sections based on existing laboratory data, thereby estimating the potential differences between other laboratories’ existing data and their own measurement results. Experimental measurements of photonuclear reactions on the newly constructed SLEGS beamline will contribute to clarifying the differences in cross-sections within the existing data. Photoneutron reaction Bayesian neural network Machine learning Gamma source SLEGS 来自: 孙乾坤 分类: 物理学 >> 核物理学 说明: 已被Nuclear Science and Techniques期刊接收 投稿状态: 已被期刊接收 引用: ChinaXiv:202411.00202 (或此版本 ChinaXiv:202411.00202V1 ) DOI:10.12074/202411.00202 CSTR:32003.36.ChinaXiv.202411.00202 科创链TXID: 197016ef-a392-4705-b927-8824ed0ffe4c 推荐引用方式: Qian-KunSun,YueZhang,Zi-RuiHao,Hong-WeiWang,Gong-TaoFan,Hang-HuaXu,Long-XiangLiu,ShengJin,Yu-XuanYang,Kai-JieChen,Zhen-WeiWang.Enhancing Reliability in Photonuclear Cross-Section Fitting with Bayesian Neural Networks.中国科学院科技论文预发布平台.[DOI:10.12074/202411.00202] 版本历史 [V1] 2024-11-19 12:05:40 ChinaXiv:202411.00202V1 下载全文

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25NASA Technical Reports Server (NTRS) 20090028756: Using Bayesian Networks For Candidate Generation In Consistency-based Diagnosis

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Consistency-based diagnosis relies heavily on the assumption that discrepancies between model predictions and sensor observations can be detected accurately. When sources of uncertainty like sensor noise and model abstraction exist robust schemes have to be designed to make a binary decision on whether predictions are consistent with observations. This risks the occurrence of false alarms and missed alarms when an erroneous decision is made. Moreover when multiple sensors (with differing sensing properties) are available the degree of match between predictions and observations can be used to guide the search for fault candidates. In this paper we propose a novel approach to handle this problem using Bayesian networks. In the consistency- based diagnosis formulation, automatically generated Bayesian networks are used to encode a probabilistic measure of fit between predictions and observations. A Bayesian network inference algorithm is used to compute most probable fault candidates.

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26NASA Technical Reports Server (NTRS) 20100033689: Portfolios In Stochastic Local Search: Efficiently Computing Most Probable Explanations In Bayesian Networks

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Portfolio methods support the combination of different algorithms and heuristics, including stochastic local search (SLS) heuristics, and have been identified as a promising approach to solve computationally hard problems. While successful in experiments, theoretical foundations and analytical results for portfolio-based SLS heuristics are less developed. This article aims to improve the understanding of the role of portfolios of heuristics in SLS. We emphasize the problem of computing most probable explanations (MPEs) in Bayesian networks (BNs). Algorithmically, we discuss a portfolio-based SLS algorithm for MPE computation, Stochastic Greedy Search (SGS). SGS supports the integration of different initialization operators (or initialization heuristics) and different search operators (greedy and noisy heuristics), thereby enabling new analytical and experimental results. Analytically, we introduce a novel Markov chain model tailored to portfolio-based SLS algorithms including SGS, thereby enabling us to analytically form expected hitting time results that explain empirical run time results. For a specific BN, we show the benefit of using a homogenous initialization portfolio. To further illustrate the portfolio approach, we consider novel additive search heuristics for handling determinism in the form of zero entries in conditional probability tables in BNs. Our additive approach adds rather than multiplies probabilities when computing the utility of an explanation. We motivate the additive measure by studying the dramatic impact of zero entries in conditional probability tables on the number of zero-probability explanations, which again complicates the search process. We consider the relationship between MAXSAT and MPE, and show that additive utility (or gain) is a generalization, to the probabilistic setting, of MAXSAT utility (or gain) used in the celebrated GSAT and WalkSAT algorithms and their descendants. Utilizing our Markov chain framework, we show that expected hitting time is a rational function - i.e. a ratio of two polynomials - of the probability of applying an additive search operator. Experimentally, we report on synthetically generated BNs as well as BNs from applications, and compare SGSs performance to that of Hugin, which performs BN inference by compilation to and propagation in clique trees. On synthetic networks, SGS speeds up computation by approximately two orders of magnitude compared to Hugin. In application networks, our approach is highly competitive in Bayesian networks with a high degree of determinism. In addition to showing that stochastic local search can be competitive with clique tree clustering, our empirical results provide an improved understanding of the circumstances under which portfolio-based SLS outperforms clique tree clustering and vice versa.

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27DTIC ADA370490: Stochastic Algorithms For Learning With Incomplete Data: An Application To Bayesian Networks

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A goal of machine learning is to develop intelligent systems that improve with experience. To achieve this goal the field has drawn on many diverse disciplines. Because of this diversity, there is no common framework for the field to develop a research vision. This research begins by proposing a machine learning framework. From the framework three hypotheses pertaining to learning Bayesian networks are proposed. The current state-of-the-art learning paradigm for inducing Bayesian networks from incomplete data involves using deterministic greedy hill-climbing algorithms. These algorithms suffer the fate of getting "stuck" at the nearest local maximum. In order to get around this problem, researchers use random restarts. The first hypotheses is that stochastic population-based algorithms will find networks with "good" predictive performance and do not get "stuck" at the nearest local maximum. I demonstrate this hypothesis with an evolutionary algorithm and a Markov Chain Monte Carlo algorithm. A problem with the Markov Chain Monte Carlo algorithm is that it is slow to converge to the stationary distribution. The second hypothesis developed from the framework is that using global information to propose new states will speed convergence. Finally, because the population-based algorithms have multiple models readily available, I explore the hypothesis that multiple models have a better predictive capability than the single "best" model. I demonstrate these hypotheses empirically with three carefully selected datasets.

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28A Quantitative Assessment Of The Effect Of Different Algorithmic Schemes To The Task Of Learning The Structure Of Bayesian Networks

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One of the most challenging tasks when adopting Bayesian Networks (BNs) is the one of learning their structure from data. This task is complicated by the huge search space of possible solutions and turned out to be a well-known NP-hard problem and, hence, approximations are required. However, to the best of our knowledge, a quantitative analysis of the performance and characteristics of the different heuristics to solve this problem has never been done before. For this reason, in this work, we provide a detailed study of the different state-of-the-arts methods for structural learning on simulated data considering both BNs with discrete and continuous variables, and with different rates of noise in the data. In particular, we investigate the characteristics of different widespread scores proposed for the inference and the statistical pitfalls within them.

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29Robust Clinical Outcome Prediction Based On Bayesian Analysis Of Transcriptional Profiles And Prior Causal Networks.

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This article is from Bioinformatics , volume 30 . Abstract Motivation: Understanding and predicting an individual’s response in a clinical trial is the key to better treatments and cost-effective medicine. Over the coming years, more and more large-scale omics datasets will become available to characterize patients with complex and heterogeneous diseases at a molecular level. Unfortunately, genetic, phenotypical and environmental variation is much higher in a human trial population than currently modeled or measured in most animal studies. In our experience, this high variability can lead to failure of trained predictors in independent studies and undermines the credibility and utility of promising high-dimensional datasets.Methods: We propose a method that utilizes patient-level genome-wide expression data in conjunction with causal networks based on prior knowledge. Our approach determines a differential expression profile for each patient and uses a Bayesian approach to infer corresponding upstream regulators. These regulators and their corresponding posterior probabilities of activity are used in a regularized regression framework to predict response.Results: We validated our approach using two clinically relevant phenotypes, namely acute rejection in kidney transplantation and response to Infliximab in ulcerative colitis. To demonstrate pitfalls in translating trained predictors across independent trials, we analyze performance characteristics of our approach as well as alternative feature sets in the regression on two independent datasets for each phenotype. We show that the proposed approach is able to successfully incorporate causal prior knowledge to give robust performance estimates.Contact:[email protected] information:Supplementary data are available at Bioinformatics online.

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30"Ideal Parent" Structure Learning For Continuous Variable Bayesian Networks

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This article is from Bioinformatics , volume 30 . Abstract Motivation: Understanding and predicting an individual’s response in a clinical trial is the key to better treatments and cost-effective medicine. Over the coming years, more and more large-scale omics datasets will become available to characterize patients with complex and heterogeneous diseases at a molecular level. Unfortunately, genetic, phenotypical and environmental variation is much higher in a human trial population than currently modeled or measured in most animal studies. In our experience, this high variability can lead to failure of trained predictors in independent studies and undermines the credibility and utility of promising high-dimensional datasets.Methods: We propose a method that utilizes patient-level genome-wide expression data in conjunction with causal networks based on prior knowledge. Our approach determines a differential expression profile for each patient and uses a Bayesian approach to infer corresponding upstream regulators. These regulators and their corresponding posterior probabilities of activity are used in a regularized regression framework to predict response.Results: We validated our approach using two clinically relevant phenotypes, namely acute rejection in kidney transplantation and response to Infliximab in ulcerative colitis. To demonstrate pitfalls in translating trained predictors across independent trials, we analyze performance characteristics of our approach as well as alternative feature sets in the regression on two independent datasets for each phenotype. We show that the proposed approach is able to successfully incorporate causal prior knowledge to give robust performance estimates.Contact:[email protected] information:Supplementary data are available at Bioinformatics online.

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31VC5N-SY5M: The Interchange Format For Bayesian Networks

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32Learning Topic Models And Latent Bayesian Networks Under Expansion Constraints

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Unsupervised estimation of latent variable models is a fundamental problem central to numerous applications of machine learning and statistics. This work presents a principled approach for estimating broad classes of such models, including probabilistic topic models and latent linear Bayesian networks, using only second-order observed moments. The sufficient conditions for identifiability of these models are primarily based on weak expansion constraints on the topic-word matrix, for topic models, and on the directed acyclic graph, for Bayesian networks. Because no assumptions are made on the distribution among the latent variables, the approach can handle arbitrary correlations among the topics or latent factors. In addition, a tractable learning method via $\ell_1$ optimization is proposed and studied in numerical experiments.

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33Building Complex Networks Through Classical And Bayesian Statistics - A Comparison

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This research is about studying and comparing two different ways of building complex networks. The main goal of our study is to find an effective way to build networks, particularly when we have fewer observations than variables. We construct networks estimating the partial correlation coefficient on Classic Statistics (Inverse Method) and on Bayesian Statistics (Normal - Inverse Wishart conjugate prior). In this current work, in order to solve the problem of having less observations than variables, we propose a new methodology called local partial correlation, which consists of selecting, for each pair of variables, the other variables most correlated to the pair.We applied these methods on simulated data and compared them through ROC curves. The most attractive result is that, even though it has high computational costs, to use Bayesian inference on trees is better when we have less observations than variables. In other cases, both approaches present satisfactory results.

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34Analysis Of The ICT User Profile For E-goverment Through Bayesian Networks

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Since the use of information and communication technologies has now become indispensable for the development of human activity, governments have assumed the responsibility of ensuring access to them, as is the case in Mexico, generating a series of public policies aimed at that end. However, these politics have not generated the expected results since there are yet large differences to internet connectivity. This research presents an analysis of the availability and use of information and communication technologies. Diverse studies indicate that there is a verifiable inequality in terms of access to technologies, this difference is remarkable between municipalities and between regions. The analysis has allowed to know the main activities that the population makes through the ICT with the objective of determining the actions in matters of digital policies that must be considered by the local government. From the analysis performed it can be concluded that the majority of the population that Internet accesses does it through a desktop, laptop computer or a mobile phone. The most actions performed by the population through the internet are actions of entertainment and downloading software, as well as the search for general information, but participating in government affairs is not a priority issue. The population interested in public affairs is the one with the highest educational level, then that the institution requires the development of mechanisms to strengthen citizen participation in the taking of public affairs. It is also required to increase the communications infrastructure then that a greater percentage of the population can access the Internet. The programs on the use of technologies that must be developed by the government must be adapted. The study shows that the completion of procedures is not a priority issue, then that the implementation of electronic services may not have much impact on the Entity. It is necessary at first then to promote the development of the population's capacities to use of communication technologies. As a result, in this moment not have conditions to guarantee the success of an e-government policy such as the implementation of electronic payments and the use of mobile applications. It is necessary to overcome connectivity deficiencies and develop digital literacy actions to ensure the productive use of technologies. Elia Martínez | Guillermo De la Torre-Gea"Analysis of the ICT user Profile for e-goverment through Bayesian Networks" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-2 , February 2018, URL: http://www.ijtsrd.com/papers/ijtsrd2407.pdf  http://www.ijtsrd.com/other-scientific-research-area/other/2407/analysis-of-the-ict-user-profile-for-e-goverment--through-bayesian-networks/elia-martínez

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35Concave Penalized Estimation Of Sparse Gaussian Bayesian Networks

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We develop a penalized likelihood estimation framework to estimate the structure of Gaussian Bayesian networks from observational data. In contrast to recent methods which accelerate the learning problem by restricting the search space, our main contribution is a fast algorithm for score-based structure learning which does not restrict the search space in any way and works on high-dimensional datasets with thousands of variables. Our use of concave regularization, as opposed to the more popular $\ell_0$ (e.g. BIC) penalty, is new. Moreover, we provide theoretical guarantees which generalize existing asymptotic results when the underlying distribution is Gaussian. Most notably, our framework does not require the existence of a so-called faithful DAG representation, and as a result the theory must handle the inherent nonidentifiability of the estimation problem in a novel way. Finally, as a matter of independent interest, we provide a comprehensive comparison of our approach to several standard structure learning methods using open-source packages developed for the R language. Based on these experiments, we show that our algorithm is significantly faster than other competing methods while obtaining higher sensitivity with comparable false discovery rates for high-dimensional data. In particular, the total runtime for our method to generate a solution path of 20 estimates for DAGs with 8000 nodes is around one hour.

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36Mean Field Variational Approximation For Continuous-Time Bayesian Networks

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We develop a penalized likelihood estimation framework to estimate the structure of Gaussian Bayesian networks from observational data. In contrast to recent methods which accelerate the learning problem by restricting the search space, our main contribution is a fast algorithm for score-based structure learning which does not restrict the search space in any way and works on high-dimensional datasets with thousands of variables. Our use of concave regularization, as opposed to the more popular $\ell_0$ (e.g. BIC) penalty, is new. Moreover, we provide theoretical guarantees which generalize existing asymptotic results when the underlying distribution is Gaussian. Most notably, our framework does not require the existence of a so-called faithful DAG representation, and as a result the theory must handle the inherent nonidentifiability of the estimation problem in a novel way. Finally, as a matter of independent interest, we provide a comprehensive comparison of our approach to several standard structure learning methods using open-source packages developed for the R language. Based on these experiments, we show that our algorithm is significantly faster than other competing methods while obtaining higher sensitivity with comparable false discovery rates for high-dimensional data. In particular, the total runtime for our method to generate a solution path of 20 estimates for DAGs with 8000 nodes is around one hour.

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37Differential Gene Co-expression Networks Via Bayesian Biclustering Models

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Identifying latent structure in large data matrices is essential for exploring biological processes. Here, we consider recovering gene co-expression networks from gene expression data, where each network encodes relationships between genes that are locally co-regulated by shared biological mechanisms. To do this, we develop a Bayesian statistical model for biclustering to infer subsets of co-regulated genes whose covariation may be observed in only a subset of the samples. Our biclustering method, BicMix, has desirable properties, including allowing overcomplete representations of the data, computational tractability, and jointly modeling unknown confounders and biological signals. Compared with related biclustering methods, BicMix recovers latent structure with higher precision across diverse simulation scenarios. Further, we develop a method to recover gene co-expression networks from the estimated sparse biclustering matrices. We apply BicMix to breast cancer gene expression data and recover a gene co-expression network that is differential across ER+ and ER- samples.

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38A QoS Guarantee Strategy For Multimedia Conferencing Based On Bayesian Networks

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Service Oriented Architecture (SOA) is commonly employed in the design and implementation of web service systems. The key technology to enable media communications in the context of SOA is the Service Oriented Communication. To exploit the advantage of SOA, we design and implement a web-based multimedia conferencing system that provides users with a hybrid orchestration of web and communication services. As the current SOA lacks effective QoS guarantee solutions for multimedia services, the user satisfaction is greatly challenged with QoS violations, e.g., low video PSNR (Peak Signal-to-Noise Ratio) and long playback delay. Motivated by addressing the critical problem, we firstly employ the Business Process Execution Language (BPEL) service engine for the hybrid services orchestration and execution. Secondly, we propose a novel context-aware approach to quantify and leverage the causal relationships between QoS metrics and available contexts based on Bayesian networks (CABIN). This approach includes three phases: (1) information discretization, (2) causal relationship profiling, and (3) optimal context tuning. We implement CABIN in a real-life multimedia conferencing system and compare its performance with existing delay and throughput oriented schemes. Experimental results show that CABIN outperforms the competing approaches in improving the video quality in terms of PSNR. It also provides a one-stop shop controls both the web and communication services.

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39Conditional Plausibility Measures And Bayesian Networks

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A general notion of algebraic conditional plausibility measures is defined. Probability measures, ranking functions, possibility measures, and (under the appropriate definitions) sets of probability measures can all be viewed as defining algebraic conditional plausibility measures. It is shown that algebraic conditional plausibility measures can be represented using Bayesian networks.

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40Scalable Bayesian Learning Of Recurrent Neural Networks For Language Modeling

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Recurrent neural networks (RNNs) have shown promising performance for language modeling. However, traditional training of RNNs using back-propagation through time often suffers from overfitting. One reason for this is that stochastic optimization (used for large training sets) does not provide good estimates of model uncertainty. This paper leverages recent advances in stochastic gradient Markov Chain Monte Carlo (also appropriate for large training sets) to learn weight uncertainty in RNNs. It yields a principled Bayesian learning algorithm, adding gradient noise during training (enhancing exploration of the model-parameter space) and model averaging when testing. Extensive experiments on various RNN models and across a broad range of applications demonstrate the superiority of the proposed approach over stochastic optimization.

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41Learning And Policy Search In Stochastic Dynamical Systems With Bayesian Neural Networks

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We present an algorithm for model-based reinforcement learning that combines Bayesian neural networks (BNNs) with random roll-outs and stochastic optimization for policy learning. The BNNs are trained by minimizing $\alpha$-divergences, allowing us to capture complicated statistical patterns in the transition dynamics, e.g. multi-modality and heteroskedasticity, which are usually missed by other common modeling approaches. We illustrate the performance of our method by solving a challenging benchmark where model-based approaches usually fail and by obtaining promising results in a real-world scenario for controlling a gas turbine.

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42Data-Driven Confounder Selection Via Markov And Bayesian Networks

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To unbiasedly estimate a causal effect on an outcome unconfoundedness is often assumed. If there is sufficient knowledge on the underlying causal structure then existing confounder selection criteria can be used to select subsets of the observed pretreatment covariates, $X$, sufficient for unconfoundedness, if such subsets exist. Here, estimation of these target subsets is considered when the underlying causal structure is unknown. The proposed method is to model the causal structure by a probabilistic graphical model, e.g., a Markov or Bayesian network, estimate this graph from observed data and select the target subsets given the estimated graph. The approach is evaluated by simulation both in a high-dimensional setting where unconfoundedness holds given $X$ and in a setting where unconfoundedness only holds given subsets of $X$. Several common target subsets are investigated and the selected subsets are compared with respect to accuracy in estimating the average causal effect. The proposed method is implemented with existing software that can easily handle high-dimensional data, in terms of large samples and large number of covariates. The results from the simulation study show that, if unconfoundedness holds given $X$, this approach is very successful in selecting the target subsets, outperforming alternative approaches based on random forests and LASSO, and that the subset estimating the target subset containing all causes of outcome yields smallest MSE in the average causal effect estimation.

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43Probabilistic Inferences In Bayesian Networks

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Bayesian network is a complete model for the variables and their relationships, it can be used to answer probabilistic queries about them. A Bayesian network can thus be considered a mechanism for automatically applying Bayes' theorem to complex problems. In the application of Bayesian networks, most of the work is related to probabilistic inferences. Any variable updating in any node of Bayesian networks might result in the evidence propagation across the Bayesian networks. This paper sums up various inference techniques in Bayesian networks and provide guidance for the algorithm calculation in probabilistic inference in Bayesian networks.

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44Algebraic Geometry Of Gaussian Bayesian Networks

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Conditional independence models in the Gaussian case are algebraic varieties in the cone of positive definite covariance matrices. We study these varieties in the case of Bayesian networks, with a view towards generalizing the recursive factorization theorem to situations with hidden variables. In the case when the underlying graph is a tree, we show that the vanishing ideal of the model is generated by the conditional independence statements implied by graph. We also show that the ideal of any Bayesian network is homogeneous with respect to a multigrading induced by a collection of upstream random variables. This has a number of important consequences for hidden variable models. Finally, we relate the ideals of Bayesian networks to a number of classical constructions in algebraic geometry including toric degenerations of the Grassmannian, matrix Schubert varieties, and secant varieties.

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45Testing Bayesian Networks

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This work initiates a systematic investigation of testing {\em high-dimensional} structured distributions by focusing on testing {\em Bayesian networks} -- the prototypical family of directed graphical models. A Bayesian network is defined by a directed acyclic graph, where we associate a random variable with each node. The value at any particular node is conditionally independent of all the other non-descendant nodes once its parents are fixed. Specifically, we study the properties of identity testing and closeness testing of Bayesian networks. Our main contribution is the first non-trivial efficient testing algorithms for these problems and corresponding information-theoretic lower bounds. For a wide range of parameter settings, our testing algorithms have sample complexity {\em sublinear} in the dimension and are sample-optimal, up to constant factors.

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46MULTIMODAL MEDICAL CASE RETRIEVAL USING BAYESIAN NETWORKS AND THE DEZERT-SMARANDACHE THEORY

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In this paper, we present a Case Based Reasoning (CBR) system for the retrieval of medical cases made up of a series of images with semantic information (such as the patient age, sex and medical history).

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47Feature Dynamic Bayesian Networks

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Feature Markov Decision Processes (PhiMDPs) are well-suited for learning agents in general environments. Nevertheless, unstructured (Phi)MDPs are limited to relatively simple environments. Structured MDPs like Dynamic Bayesian Networks (DBNs) are used for large-scale real-world problems. In this article I extend PhiMDP to PhiDBN. The primary contribution is to derive a cost criterion that allows to automatically extract the most relevant features from the environment, leading to the "best" DBN representation. I discuss all building blocks required for a complete general learning algorithm.

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48Bayesian Networks For Migration, International Remittances, Trade, Foreign Direct Investments, Inflation, Real Interest Rate And Employment In Georgia

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Migration has long been a topic of interest in Georgia, given its small economy, population, and unique history and culture. The main objective of this study is to examine the factors affecting emigration and immigration in Georgia and identify the dependencies among various macroeconomic variables, such as international remittances, trade, foreign direct investment (FDI), inflation, real interest rates, and employment. Using data spanning from 2002 to 2023, the study applies a machine learning technique, specifically Bayesian Networks, to analyze these relationships. The findings are discussed, and conclusions are drawn, along with recommendations for both the government and researchers for further exploration. To our knowledge, this is the first study to apply the Bayesian Network algorithm to investigate these dynamics in Georgia, filling an important research gap. The results indicate that both immigration and emigration are affected by remittances paid, with emigration also being dependent on employment. It was found that remittances received and exports are directly influenced by remittances paid, while imports are affected by both exports and employment. Additionally, remittances received are directly dependent on imports, and the real interest rate is influenced by both imports and inflation (CPI). FDI is shown to be dependent on inflation, imports, and remittances received. Furthermore, both emigration and immigration are dependent on exports, imports, and remittances received, with immigration also exhibiting a dependency on FDI.

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49Improving Object Detection With Deep Convolutional Networks Via Bayesian Optimization And Structured Prediction

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Object detection systems based on the deep convolutional neural network (CNN) have recently made ground- breaking advances on several object detection benchmarks. While the features learned by these high-capacity neural networks are discriminative for categorization, inaccurate localization is still a major source of error for detection. Building upon high-capacity CNN architectures, we address the localization problem by 1) using a search algorithm based on Bayesian optimization that sequentially proposes candidate regions for an object bounding box, and 2) training the CNN with a structured loss that explicitly penalizes the localization inaccuracy. In experiments, we demonstrated that each of the proposed methods improves the detection performance over the baseline method on PASCAL VOC 2007 and 2012 datasets. Furthermore, two methods are complementary and significantly outperform the previous state-of-the-art when combined.

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50A Bayesian Framework That Integrates Heterogeneous Data For Inferring Gene Regulatory Networks.

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This article is from Frontiers in Bioengineering and Biotechnology , volume 2 . Abstract Reconstruction of gene regulatory networks (GRNs) from experimental data is a fundamental challenge in systems biology. A number of computational approaches have been developed to infer GRNs from mRNA expression profiles. However, expression profiles alone are proving to be insufficient for inferring GRN topologies with reasonable accuracy. Recently, it has been shown that integration of external data sources (such as gene and protein sequence information, gene ontology data, protein–protein interactions) with mRNA expression profiles may increase the reliability of the inference process. Here, I propose a new approach that incorporates transcription factor binding sites (TFBS) and physical protein interactions (PPI) among transcription factors (TFs) in a Bayesian variable selection (BVS) algorithm which can infer GRNs from mRNA expression profiles subjected to genetic perturbations. Using real experimental data, I show that the integration of TFBS and PPI data with mRNA expression profiles leads to significantly more accurate networks than those inferred from expression profiles alone. Additionally, the performance of the proposed algorithm is compared with a series of least absolute shrinkage and selection operator (LASSO) regression-based network inference methods that can also incorporate prior knowledge in the inference framework. The results of this comparison suggest that BVS can outperform LASSO regression-based method in some circumstances.

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  • Title: ➤  A Bayesian Framework That Integrates Heterogeneous Data For Inferring Gene Regulatory Networks.
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  • Language: English

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