Unexpected Improvements Of Spatial Learning And Memory Abilities In Chronic Rotenone Intoxicated Mice. - Info and Reading Options
By Jia, Fengju, Song, Ning, Zhao, Chenyang, Xie, Junxia and Jiang, Hong
"Unexpected Improvements Of Spatial Learning And Memory Abilities In Chronic Rotenone Intoxicated Mice." and the language of the book is English.
“Unexpected Improvements Of Spatial Learning And Memory Abilities In Chronic Rotenone Intoxicated Mice.” Metadata:
- Title: ➤ Unexpected Improvements Of Spatial Learning And Memory Abilities In Chronic Rotenone Intoxicated Mice.
- Authors: Jia, FengjuSong, NingZhao, ChenyangXie, JunxiaJiang, Hong
- Language: English
Edition Identifiers:
- Internet Archive ID: pubmed-PMC3950215
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"Unexpected Improvements Of Spatial Learning And Memory Abilities In Chronic Rotenone Intoxicated Mice." Description:
The Internet Archive:
This article is from <a href="//archive.org/search.php?query=journaltitle%3A%28PLoS%20ONE%29" rel="nofollow">PLoS ONE</a>, <a href="//archive.org/search.php?query=journaltitle%3A%28PLoS%20ONE%29%20AND%20volume%3A%289%29" rel="nofollow">volume 9</a>.<h2>Abstract</h2>The liposoluble insecticide rotenone is commonly used as a mitochondrial complex I inhibitor to replicate Parkinson's disease (PD) pathological features. However, there was no assessment of the spatial learning and memory abilities in chronic rotenone-induced PD models. In the present study, by rotarod test and Thioflavine T staining, we first noted the impairment of motor coordination in rotenone-treated group for 3 months, as well as alpha-synuclein inclusions in the nigral dopaminergic neurons in C57BL/6 mice with intragastrical delivery of rotenone (5 mg/Kg) for 3 months rather than 1 month. We then evaluated spatial learning and memory abilities by Morris water maze task in this model. The results showed escape latency reduced in rotenone-intoxicated mice for 3 months, indicating an improvement of learning ability. However, it was delayed slightly but not significantly in rotenone-intoxicated mice for 1 month. Similarly, we demonstrated that spatial memory ability was enhanced in 3-month-treatment group, but impaired in 1-month-treatment group. There were no proliferating cell nuclear antigen and doublecortin positive cells in the hippocampus by double immunofluorescent staining, indicating the absence of hippocampal neurogenesis in rotenone-intoxicated mice. These results suggest that spatial learning and memory abilities are disturbed in chronic rotenone-intoxicated PD model.
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