The Negative Interplay Between Aurora A/B And BRCA1/2 Controls Cancer Cell Growth And Tumorigenesis Via Distinct Regulation Of Cell Cycle Progression, Cytokinesis, And Tetraploidy. - Info and Reading Options

The Internet Archive:

This article is from <a href="//archive.org/search.php?query=journaltitle%3A%28Molecular%20Cancer%29" rel="nofollow">Molecular Cancer</a>, <a href="//archive.org/search.php?query=journaltitle%3A%28Molecular%20Cancer%29%20AND%20volume%3A%2813%29" rel="nofollow">volume 13</a>.<h2>Abstract</h2>It is well known that the activation of Aurora A/B (Aur A/B) or inactivation of BRCA1/2 induces tumor formation. Others and we have reported that the mutual suppression between Aur A/B and BRCA1/2 may manipulate cancer cell growth and tumorigenesis, however, the interactive regulation and mechanism between these molecules are still elusive. In this study, by consecutive silencing of Aur A/B or/and BRCA1/2 with specific shRNAs, we showed that, in BRCA2-deficient pancreatic cancer cell line Capan-1 and in ovarian cancer cell line OVCA433, Aur A/B and BRCA1/2 inversely regulated the expression of each other likely through proteasome-mediated proteolysis but not through gene transcription. Aur A/B and BRCA1/2 conversely regulated cell cycle progression mainly through control of p53 and cyclin A. Moreover, the disruption of Aur A/B blocked abnormal cytokinesis and decreased cell multinuclearity and chromosome tetraploidy, whereas the deprivation of BRCA1/2 promoted the abnormal cytokinesis and enhanced the cell multinuclearity and tetraploidy. Furthermore, we showed by animal assays that the depletion of Aur A/B inhibited tumor growth of both cell lines, while the knockdown of BRCA1/2 promoted the tumor growth. However, the concurrent silencing of Aur A/B and BRCA1/2 diminished the effects of these molecules on the regulation of cell cycle, cytokinesis, and tetraploidy, leading to the burdened tumor sizes similar to those induced by scrambled shRNA-treated control cells. In summary, our study revealed that the negative interplay between Aur A/B and BRCA1/2 inversely controls the cell proliferation, cell cycle progression, cell multinuclearity, and tetraploidization to modulate tumorigenesis.

Search for “The Negative Interplay Between Aurora A/B And BRCA1/2 Controls Cancer Cell Growth And Tumorigenesis Via Distinct Regulation Of Cell Cycle Progression, Cytokinesis, And Tetraploidy.” downloads:

Visit our Downloads Search page to see if downloads are available.

Find “The Negative Interplay Between Aurora A/B And BRCA1/2 Controls Cancer Cell Growth And Tumorigenesis Via Distinct Regulation Of Cell Cycle Progression, Cytokinesis, And Tetraploidy.” in Libraries Near You:

Read or borrow “The Negative Interplay Between Aurora A/B And BRCA1/2 Controls Cancer Cell Growth And Tumorigenesis Via Distinct Regulation Of Cell Cycle Progression, Cytokinesis, And Tetraploidy.” from your local library.

• The WorldCat Libraries Catalog: Find a copy of “The Negative Interplay Between Aurora A/B And BRCA1/2 Controls Cancer Cell Growth And Tumorigenesis Via Distinct Regulation Of Cell Cycle Progression, Cytokinesis, And Tetraploidy.” at a library near you.