"The CD27L And CTP1L Endolysins Targeting Clostridia Contain A Built-in Trigger And Release Factor." - Information and Links:

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"The CD27L And CTP1L Endolysins Targeting Clostridia Contain A Built-in Trigger And Release Factor." and the language of the book is English.


“The CD27L And CTP1L Endolysins Targeting Clostridia Contain A Built-in Trigger And Release Factor.” Metadata:

  • Title: ➤  The CD27L And CTP1L Endolysins Targeting Clostridia Contain A Built-in Trigger And Release Factor.
  • Authors: ➤  
  • Language: English

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  • Internet Archive ID: pubmed-PMC4110038

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"The CD27L And CTP1L Endolysins Targeting Clostridia Contain A Built-in Trigger And Release Factor." Description:

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This article is from <a href="//archive.org/search.php?query=journaltitle%3A%28PLoS%20Pathogens%29" rel="nofollow">PLoS Pathogens</a>, <a href="//archive.org/search.php?query=journaltitle%3A%28PLoS%20Pathogens%29%20AND%20volume%3A%2810%29" rel="nofollow">volume 10</a>.<h2>Abstract</h2>The bacteriophage ΦCD27 is capable of lysing Clostridium difficile, a pathogenic bacterium that is a major cause for nosocomial infection. A recombinant CD27L endolysin lyses C. difficile in vitro, and represents a promising alternative as a bactericide. To better understand the lysis mechanism, we have determined the crystal structure of an autoproteolytic fragment of the CD27L endolysin. The structure covers the C-terminal domain of the endolysin, and represents a novel fold that is identified in a number of lysins that target Clostridia bacteria. The structure indicates endolysin cleavage occurs at the stem of the linker connecting the catalytic domain with the C-terminal domain. We also solved the crystal structure of the C-terminal domain of a slow cleaving mutant of the CTP1L endolysin that targets C. tyrobutyricum. Two distinct dimerization modes are observed in the crystal structures for both endolysins, despite a sequence identity of only 22% between the domains. The dimers are validated to be present for the full length protein in solution by right angle light scattering, small angle X-ray scattering and cross-linking experiments using the cross-linking amino acid p-benzoyl-L-phenylalanine (pBpa). Mutagenesis on residues contributing to the dimer interfaces indicates that there is a link between the dimerization modes and the autocleavage mechanism. We show that for the CTP1L endolysin, there is a reduction in lysis efficiency that is proportional to the cleavage efficiency. We propose a model for endolysin triggering, where the extended dimer presents the inactive state, and a switch to the side-by-side dimer triggers the cleavage of the C-terminal domain. This leads to the release of the catalytic portion of the endolysin, enabling the efficient digestion of the bacterial cell wall.

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