Risk And Protective Genetic Variants In Suicidal Behaviour: Association With SLC1A2, SLC1A3, 5-HTR1B &NTRK2 Polymorphisms. - Info and Reading Options

The Internet Archive:

This article is from <a href="//archive.org/search.php?query=journaltitle%3A%28Behavioral%20and%20Brain%20Functions%20:%20BBF%29" rel="nofollow">Behavioral and Brain Functions : BBF</a>, <a href="//archive.org/search.php?query=journaltitle%3A%28Behavioral%20and%20Brain%20Functions%20:%20BBF%29%20AND%20volume%3A%287%29" rel="nofollow">volume 7</a>.<h2>Abstract</h2>Background: Suicidal behaviour is known to aggregate in families. Patients with psychiatric disorders are at higher risk for suicide attempts (SA), however protective and risk genetic variants for suicide appear to be independent of underlying psychiatric disorders. Here we investigate genetic variants in genes important for neurobiological pathways linked to suicidal behaviour and/or associated endophenotypes, for association with SA among patients with co-existing psychiatric illness. Selected gene-gene and gene-environment interactions were also tested. Methods: DNA was obtained from bloods of 159 patients (76 suicide attempters and 83 non-attempters), who were profiled for DSM-IV Axis I psychiatric diagnosis. Twenty-eight single nucleotide polymorphisms (SNPs) from 18 candidate genes (COMT, 5-HT2A, 5-HT1A, 5-HTR1B, TPH1, MAO-A, TPH2, DBH, CNR1, BDNF, ABCG1, GABRA5, GABRG2, GABRB2, SLC1A2, SLC1A3, NTRK2, CRHR1) were genotyped. Genotyping was performed by KBioscience. Tests of association between genetic variants and SA were conducted using Chi squared and Armitage Trend tests. Binary logistical regression analyses were performed to evaluate the contribution of individual genetic variants to the prediction of SA, and to examine SNPs for potential gene-gene and gene-environment interactions. Results: Our analysis identified 4 SNPs (rs4755404, rs2269272, rs6296 and rs1659400), which showed evidence of association with SA compared to a non-attempter control group. We provide evidence of a 3-locus gene-gene interaction, and a putative gene-environment interaction, whereby genetic variation at the NTRK2 locus may moderate the risk associated with history of childhood abuse. Conclusion: Preliminary findings suggest that allelic variability in SLC1A2/3, 5-HTR1B and NTRK2 may be relevant to the underlying diathesis for suicidal acts.

Search for “Risk And Protective Genetic Variants In Suicidal Behaviour: Association With SLC1A2, SLC1A3, 5-HTR1B &NTRK2 Polymorphisms.” downloads:

Visit our Downloads Search page to see if downloads are available.

Find “Risk And Protective Genetic Variants In Suicidal Behaviour: Association With SLC1A2, SLC1A3, 5-HTR1B &NTRK2 Polymorphisms.” in Libraries Near You:

Read or borrow “Risk And Protective Genetic Variants In Suicidal Behaviour: Association With SLC1A2, SLC1A3, 5-HTR1B &NTRK2 Polymorphisms.” from your local library.

• The WorldCat Libraries Catalog: Find a copy of “Risk And Protective Genetic Variants In Suicidal Behaviour: Association With SLC1A2, SLC1A3, 5-HTR1B &NTRK2 Polymorphisms.” at a library near you.