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“Relative Sensitivity And Specificity Of 10-2 Visual Fields, Multifocal Electroretinography, And Spectral Domain Optical Coherence Tomography In Detecting Hydroxychloroquine And Chloroquine Retinopathy.” Metadata:

  • Title: ➤  Relative Sensitivity And Specificity Of 10-2 Visual Fields, Multifocal Electroretinography, And Spectral Domain Optical Coherence Tomography In Detecting Hydroxychloroquine And Chloroquine Retinopathy.
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  • Language: English

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  • Internet Archive ID: pubmed-PMC4122553

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This article is from <a href="//archive.org/search.php?query=journaltitle%3A%28Clinical%20Ophthalmology%20(Auckland,%20N.Z.)%29" rel="nofollow">Clinical Ophthalmology (Auckland, N.Z.)</a>, <a href="//archive.org/search.php?query=journaltitle%3A%28Clinical%20Ophthalmology%20(Auckland,%20N.Z.)%29%20AND%20volume%3A%288%29" rel="nofollow">volume 8</a>.<h2>Abstract</h2>Background: The purpose of this study was to determine the relative sensitivity and specificity of 10-2 visual fields (10-2 VFs), multifocal electroretinography (mfERG), and spectral domain optical coherence tomography (SD-OCT) in detecting hydroxychloroquine retinopathy. Methods: A total of 121 patients taking hydroxychloroquine (n=119) or chloroquine (n=2) with 10-2 VF, mfERG, and SD-OCT tests were retrospectively reviewed. Rates of test abnormality were determined. Results: Retinopathy was present in 14 and absent in 107. Eleven of 14 (78.6%) patients with retinopathy were overdosed. Twelve (85.7%) had cumulative dosing greater than 1,000 g. The sensitivities of 10-2 VF, mfERG, and SD-OCT in detecting retinopathy were 85.7%, 92.9%, and 78.6%, respectively. The specificities of 10-2 VF, mfERG, and SD-OCT in detecting retinopathy were 92.5%, 86.9%, and 98.1%, respectively. Positive predictive values of 10-2 VF, mfERG, and SD-OCT in detecting retinopathy were less than 30% for all estimates of hydroxychloroquine retinopathy prevalence. Negative predictive values were >99% for all tests. Conclusion: Based on published estimates of hydroxychloroquine retinopathy prevalence, all three tests are most reliable when negative, allowing confident exclusion of retinopathy in patients taking ≤6.5 mg/kg/day. Each test is less useful in allowing a confident diagnosis of retinopathy when positive, especially in patients taking ≤6.5 mg/kg/day.

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