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“Rapid Birth-and-Death Evolution Of Imprinted SnoRNAs In The Prader-Willi Syndrome Locus: Implications For Neural Development In Euarchontoglires.” Metadata:

  • Title: ➤  Rapid Birth-and-Death Evolution Of Imprinted SnoRNAs In The Prader-Willi Syndrome Locus: Implications For Neural Development In Euarchontoglires.
  • Authors: ➤  
  • Language: English

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  • Internet Archive ID: pubmed-PMC4063771

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This article is from <a href="//archive.org/search.php?query=journaltitle%3A%28PLoS%20ONE%29" rel="nofollow">PLoS ONE</a>, <a href="//archive.org/search.php?query=journaltitle%3A%28PLoS%20ONE%29%20AND%20volume%3A%289%29" rel="nofollow">volume 9</a>.<h2>Abstract</h2>Imprinted small nucleolar RNAs (snoRNAs) are only found in eutherian genomes and closely related to brain functions. A complex human neurological disease, Prader-Willi syndrome (PWS), is primarily attributed to the deletion of imprinted snoRNAs in chromosome 15q11-q13. Here we investigated the snoRNA repertoires in the PWS locus of 12 mammalian genomes and their evolution processes. A total of 613 imprinted snoRNAs were identified in the PWS homologous loci and the gene number was highly variable across lineages, with a peak in Euarchontoglires. Lineage-specific gene gain and loss events account for most extant genes of the HBII-52 (SNORD115) and the HBII-85 (SNORD116) gene family, and remarkable high gene-birth rates were observed in the primates and the rodents. Meanwhile, rapid sequence substitution occurred only in imprinted snoRNA genes, rather than their flanking sequences or the protein-coding genes located in the same imprinted locus. Strong selective constraints on the functional elements of these imprinted snoRNAs further suggest that they are subjected to birth-and-death evolution. Our data suggest that the regulatory role of HBII-52 on 5-HT2CR pre-mRNA might originate in the Euarchontoglires through adaptive process. We propose that the rapid evolution of PWS-related imprinted snoRNAs has contributed to the neural development of Euarchontoglires.

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