Neurocognitive Networks In SCD And Across The Dementia Risk Spectrum: Investigating The Multivariate Associations Between Brain And Cognitive Measures - Info and Reading Options

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This project focuses on the brain-behavior relationships within subjective cognitive decline (SCD), a clinical condition where individuals report memory and thinking difficulties despite normal performance on cognitive tests. SCD is increasingly considered a potential early risk factor for further cognitive decline and dementia, but understanding the relationships between reported cognitive changes and possible underlying brain changes remains a challenge in this clinical state. The study will examine how structural brain changes — specifically, hippocampal volume (HV) and white matter hyperintensities (WMHs) — relate to cognitive measures in individuals with SCD. Prior research suggests that, while individuals with SCD may not perform worse on tests than cognitively unimpaired (CU) adults, they may still exhibit distinct brain-behavior associations compared to their CU peers, making these changes in association potentially useful indicators of underlying neurocognitive changes occurring at the SCD stage. Using psychometric network analysis, this study will map the conditional relationships between brain structures and cognitive domains (e.g., memory, executive function, processing speed) in SCD. This approach allows us to capture complex dynamics between various cognitive abilities and brain integrity that traditional methods may miss. Our study will then compare the SCD network to different non-clinical (CU) and clinical groups (mild cognitive impairment and Alzheimer’s disease) to investigate how these relationships compare across the dementia risk spectrum. Primary outcomes will include: (1) Identifying relationships between neurostructural and cognitive measures in the SCD group. (2) Clarifying how these neurocognitive associations in the SCD network differ from other clinical groups, particularly the CU group. Exploratory analyses will also investigate how factors like sex and APOE genetic status influence brain-behavior relationships in SCD, aiming to better understand its heterogeneity.

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