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  • Title: ➤  Linking Biodiversity To Human Health Through Epigenetics: A Scoping Review And Conceptual Framework Conception Protocol
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  • Internet Archive ID: osf-registrations-zb8qt-v1

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The objectives of this research are (1) to conduct a literature review to understand the extent and evidence on the influence of biodiversity exposure on epigenetic markers (CpG) and epigenetic clocks and (2) to develop a conceptual framework capturing the link between biodiversity and human health through epigenetics. Regarding the primary analysis of epigenetic variations as mediators, we will examine three categories of epigenetic changes associated with biodiversity exposure: (1) the biomarkers individual (CpGs), (2) the epigenetic clocks and pace of aging, (3) other epigenetic changes (histone modifications, non-coding RNAs). Each category will be evaluated based on the strength of evidence from existing studies. While epigenetic clocks are already established predictors of age-related outcomes, individual biomarkers and other modifications will be analysed for their potential mediation role in health effects. This study aims to advance our understanding of the links between biodiversity exposure, epigenetics modifications, and human health outcomes through the development of a conceptual framework. The framework could serve as a basis for further studies on this topic. The current evidence is limited to observational data, this emerging field holds promise for enhancing our knowledge of how environmental biodiversity impacts human health and well-being, providing a foundation for future investigations.

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