Introduction to Toxicology

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Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Authors -- Preface to the Fourth Edition -- Acknowledgments -- 1 Introduction -- Chapter Outline -- 1.1 Introduction -- 1.2 Historical Aspects -- 1.3 Classification of Toxic Substances -- 1.3.1 Pharmaceutical and Therapeutic Agents -- 1.3.2 Food Additives -- 1.3.3 Industrial Chemicals -- 1.3.4 Environmental Pollutants -- 1.3.5 Naturally Occurring Toxins -- 1.3.6 Household Poisons -- 1.4 Classification of Exposure -- 1.4.1 Intentional Ingestion -- 1.4.2 Occupational Exposure -- 1.4.3 Environmental Exposure -- 1.4.4 Unintentional, Accidental Poisoning -- 1.4.5 Selective Toxicity -- 1.5 Summary and Learning Objectives -- Notes -- Bibliography -- Suggested Readings -- 2 Dose-Response Relationship -- Chapter Outline -- 2.1 Basic Principles of the Dose-Response Relationship -- 2.2 Receptors -- 2.3 Synergy and Potentiation -- 2.4 Threshold Dose and NOAEL -- 2.5 Summary and Learning Objectives -- Review Questions -- Short Answer Questions -- Notes -- Bibliography -- 3 Exposure-Response Relationship -- Chapter Outline -- 3.1 Types of Exposure -- 3.1.1 Acute Exposure -- 3.1.2 Chronic Exposure -- 3.1.3 Continuous/Intermittent Exposure -- 3.2 Route of Exposure -- 3.3 Types of Toxic Response -- 3.3.1 Biochemical Lesions -- 3.3.2 Pharmacological and Physiological Effects -- 3.3.3 Immunotoxicity -- 3.3.4 Teratogenicity -- 3.3.5 Genetic Toxicity -- 3.3.6 Carcinogenicity -- 3.4 Biomarkers -- 3.5 Summary and Learning Objectives -- Review Questions -- Short Answer Questions -- Notes -- Bibliography -- 4 Disposition of Toxic Compounds -- Chapter Outline -- 4.1 Absorption of Toxic Compounds -- 4.2 Sites of Absorption -- 4.2.1 Skin -- 4.2.2 Lungs -- 4.2.3 Gastrointestinal Tract -- 4.3 Distribution of Toxic Compounds -- 4.4 Elimination -- 4.4.1 Urinary Elimination -- 4.4.2 Biliary Elimination

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