General And Specific Neural Effects Of acute Oxytocin administration: A Coordinate-based Meta-analysis Of Task-based FMRI Studies - Info and Reading Options

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Accumulating evidence indicates that the neuropeptide oxytocin modulates human cognitive, affective and social functions. Since the publication of the first fMRI study on the neural effects of intranasal oxytocin nearly 20 years ago, the number of fMRI studies on the neural effects of oxytocin has strongly increased. The findings have provided supportive evidence for using oxytocin as a major or complementary therapeutic approach for some psychiatric disorders characterized by emotional and social function deficits. However, despite the potential neurobehavioral effects of oxytocin on a range of mental and behavioral processes in humans, including cognition, emotion, reward, decision-making, and social cognition, the conclusions are primarily based on findings from isolated studies and results between studies are of great inconsistency, both within and between behavioral domains as well as within and between populations. It remains unclear whether oxytocin regulates a set of core neural modules across tasks which gate effects on a variety of functions, or if the effects vary according to specific populations, domains, and contexts. Coordinate-based meta-analysis can overcome some of these limitations related to experimental design, task paradigm, sample size and analytical method (Eickhoff et al., 2012), and is considered a powerful tool for exploring robust neural effects. Therefore, systematically integrating and quantitatively analyzing data from prior studies through meta-analysis is one promising approach to address above questions. To the best of our knowledge, four meta-analytical studies on the neural effects of oxytocin have been published to date (Grace et al., 2018; Rocchetti et al., 2014; Wang et al., 2017; Wigton et al., 2015). However, these meta-analyses did not yield consistent conclusions about which brain regions/connectomes/networks are stably affected by oxytocin, as a consequence of differences among these meta-analyses on the inclusion criteria used and the number of studies available. Apparently, a further meta-analysis with higher statistical power driven by incorporating a larger number of studies is warranted to identify robust neurofunctional effects of oxytocin and eliminate the divergence in results among former meta-analyses. It is encouraging that more than seven years have passed since the last literature retrieval in the two most recent meta-analyses (Grace et al., 2018; Wang et al., 2017), and the number of pharmaco-imaging studies for oxytocin has almost doubled during this time, rendering an updated meta-analysis practicable. Taken together, we hope to conduct an updated coordinate-based meta-analysis aimed at investigating the general effects of acute oxytocin administration on the brain across different populations and tasks, as well as population- and behavioural domain-specific brain effects of oxytocin. The encouraging increase in the number of studies targeting at the neurofunctional effects of oxytocin, more careful data examination and more rigorous data analysis in this meta-analysis, could facilitate the identification of robust and unbiased oxytocin effect, which may accelerate the determination of overarching biological frameworks and therapeutic applications of oxytocin.

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