"G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury." - Information and Links:

G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury. - Info and Reading Options

"G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury." and the language of the book is English.


“G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury.” Metadata:

  • Title: ➤  G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury.
  • Authors: ➤  
  • Language: English

Edition Identifiers:

  • Internet Archive ID: pubmed-PMC4032280

AI-generated Review of “G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury.”:


"G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury." Description:

The Internet Archive:

This article is from <a href="//archive.org/search.php?query=journaltitle%3A%28PLoS%20ONE%29" rel="nofollow">PLoS ONE</a>, <a href="//archive.org/search.php?query=journaltitle%3A%28PLoS%20ONE%29%20AND%20volume%3A%289%29" rel="nofollow">volume 9</a>.<h2>Abstract</h2>G-protein-coupled receptors (GPCRs) are the most abundant receptors in the heart and therefore are common targets for cardiovascular therapeutics. The activated GPCRs transduce their signals via heterotrimeric G-proteins. The four major families of G-proteins identified so far are specified through their α-subunit: Gαi, Gαs, Gαq and G12/13. Gαi-proteins have been reported to protect hearts from ischemia reperfusion injury. However, determining the individual impact of Gαi2 or Gαi3 on myocardial ischemia injury has not been clarified yet. Here, we first investigated expression of Gαi2 and Gαi3 on transcriptional level by quantitative PCR and on protein level by immunoblot analysis as well as by immunofluorescence in cardiac tissues of wild-type, Gαi2-, and Gαi3-deficient mice. Gαi2 was expressed at higher levels than Gαi3 in murine hearts, and irrespective of the isoform being knocked out we observed an up regulation of the remaining Gαi-protein. Myocardial ischemia promptly regulated cardiac mRNA and with a slight delay protein levels of both Gαi2 and Gαi3, indicating important roles for both Gαi isoforms. Furthermore, ischemia reperfusion injury in Gαi2- and Gαi3-deficient mice exhibited opposite outcomes. Whereas the absence of Gαi2 significantly increased the infarct size in the heart, the absence of Gαi3 or the concomitant upregulation of Gαi2 dramatically reduced cardiac infarction. In conclusion, we demonstrate for the first time that the genetic ablation of Gαi proteins has protective or deleterious effects on cardiac ischemia reperfusion injury depending on the isoform being absent.

Read “G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury.”:

Read “G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury.” by choosing from the options below.

Available Downloads for “G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury.”:

"G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury." is available for download from The Internet Archive in "texts" format, the size of the file-s is: 8.79 Mbs, and the file-s went public at Tue Oct 21 2014.

Legal and Safety Notes

Copyright Disclaimer and Liability Limitation:

A. Automated Content Display
The creation of this page is fully automated. All data, including text, images, and links, is displayed exactly as received from its original source, without any modification, alteration, or verification. We do not claim ownership of, nor assume any responsibility for, the accuracy or legality of this content.

B. Liability Disclaimer for External Content
The files provided below are solely the responsibility of their respective originators. We disclaim any and all liability, whether direct or indirect, for the content, accuracy, legality, or any other aspect of these files. By using this website, you acknowledge that we have no control over, nor endorse, the content hosted by external sources.

C. Inquiries and Disputes
For any inquiries, concerns, or issues related to the content displayed, including potential copyright claims, please contact the original source or provider of the files directly. We are not responsible for resolving any content-related disputes or claims of intellectual property infringement.

D. No Copyright Ownership
We do not claim ownership of any intellectual property contained in the files or data displayed on this website. All copyrights, trademarks, and other intellectual property rights remain the sole property of their respective owners. If you believe that content displayed on this website infringes upon your intellectual property rights, please contact the original content provider directly.

E. Fair Use Notice
Some content displayed on this website may fall under the "fair use" provisions of copyright law for purposes such as commentary, criticism, news reporting, research, or educational purposes. If you believe any content violates fair use guidelines, please reach out directly to the original source of the content for resolution.

Virus Scanning for Your Peace of Mind:

The files provided below have already been scanned for viruses by their original source. However, if you’d like to double-check before downloading, you can easily scan them yourself using the following steps:

How to scan a direct download link for viruses:

  • 1- Copy the direct link to the file you want to download (don’t open it yet).
    • (a free online tool) and paste the direct link into the provided field to start the scan.
  • 2- Visit VirusTotal (a free online tool) and paste the direct link into the provided field to start the scan.
  • 3- VirusTotal will scan the file using multiple antivirus vendors to detect any potential threats.
  • 4- Once the scan confirms the file is safe, you can proceed to download it with confidence and enjoy your content.

Available Downloads

  • Source: Internet Archive
  • Internet Archive Link: Archive.org page
  • All Files are Available: Yes
  • Number of Files: 14
  • Number of Available Files: 14
  • Added Date: 2014-10-21 22:21:51
  • Scanner: Internet Archive Python library 0.7.2
  • PPI (Pixels Per Inch): 300
  • OCR: ABBYY FineReader 9.0

Available Files:

1- Text PDF

  • File origin: original
  • File Format: Text PDF
  • File Size: 0.00 Mbs
  • File Name: PMC4032280-journal.pone.0098325.pdf
  • Direct Link: Click here

2- Item Tile

  • File origin: original
  • File Format: Item Tile
  • File Size: 0.00 Mbs
  • File Name: __ia_thumb.jpg
  • Direct Link: Click here

3- Metadata

  • File origin: original
  • File Format: Metadata
  • File Size: 0.00 Mbs
  • File Name: pubmed-PMC4032280_files.xml
  • Direct Link: Click here

4- JSON

  • File origin: original
  • File Format: JSON
  • File Size: 0.00 Mbs
  • File Name: pubmed-PMC4032280_medline.json
  • Direct Link: Click here

5- Metadata

  • File origin: original
  • File Format: Metadata
  • File Size: 0.00 Mbs
  • File Name: pubmed-PMC4032280_meta.sqlite
  • Direct Link: Click here

6- Metadata

  • File origin: original
  • File Format: Metadata
  • File Size: 0.00 Mbs
  • File Name: pubmed-PMC4032280_meta.xml
  • Direct Link: Click here

7- DjVu

  • File origin: derivative
  • File Format: DjVu
  • File Size: 0.00 Mbs
  • File Name: PMC4032280-journal.pone.0098325.djvu
  • Direct Link: Click here

8- Animated GIF

  • File origin: derivative
  • File Format: Animated GIF
  • File Size: 0.00 Mbs
  • File Name: PMC4032280-journal.pone.0098325.gif
  • Direct Link: Click here

9- Abbyy GZ

  • File origin: derivative
  • File Format: Abbyy GZ
  • File Size: 0.00 Mbs
  • File Name: PMC4032280-journal.pone.0098325_abbyy.gz
  • Direct Link: Click here

10- DjVuTXT

  • File origin: derivative
  • File Format: DjVuTXT
  • File Size: 0.00 Mbs
  • File Name: PMC4032280-journal.pone.0098325_djvu.txt
  • Direct Link: Click here

11- Djvu XML

  • File origin: derivative
  • File Format: Djvu XML
  • File Size: 0.00 Mbs
  • File Name: PMC4032280-journal.pone.0098325_djvu.xml
  • Direct Link: Click here

12- Single Page Processed JP2 ZIP

  • File origin: derivative
  • File Format: Single Page Processed JP2 ZIP
  • File Size: 0.01 Mbs
  • File Name: PMC4032280-journal.pone.0098325_jp2.zip
  • Direct Link: Click here

13- Scandata

  • File origin: derivative
  • File Format: Scandata
  • File Size: 0.00 Mbs
  • File Name: PMC4032280-journal.pone.0098325_scandata.xml
  • Direct Link: Click here

14- Archive BitTorrent

  • File origin: metadata
  • File Format: Archive BitTorrent
  • File Size: 0.00 Mbs
  • File Name: pubmed-PMC4032280_archive.torrent
  • Direct Link: Click here

Search for “G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury.” downloads:

Visit our Downloads Search page to see if downloads are available.

Find “G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury.” in Libraries Near You:

Read or borrow “G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury.” from your local library.

Buy “G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury.” online:

Shop for “G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury.” on popular online marketplaces.


Related Books


Find "G?i2- And G?i3-Deficient Mice Display Opposite Severity Of Myocardial Ischemia Reperfusion Injury." in Wikipdedia