Effects Of Continuous Theta Burst Stimulation To Dorsolateral Prefrontal Cortex On The Interaction Between Visual Working Memory And Perception - Info and Reading Options

The Internet Archive:

In this project, we will examine the effects of offline continuous theta burst stimulation to dorsolateral prefrontal cortex (dlPFC) on metacognition and the interaction between visual working memory and perception. Continuous theta burst stimulation is a transcranial magnetic stimulation (TMS) protocol whereby 50Hz “bursts” of TMS pulse triplets are delivered to a single cortical site in a continuous chain, with a carrier frequency of 5Hz (i.e. five 50hz triplets per second). Continuous theta burst stimulation has been found to elicit short-term alterations to cortical excitability, functional connectivity, and associated task behaviour, and has been routinely applied to dlPFC and visual areas under both clinical and experimental conditions. We will deliver offline neuronavigated continuous theta burst stimulation (cTBS) to area p9-46v (dlPFC) and primary motor cortex (M1), defined using individualised fMRI data (based on resting-state connectivity), and manual mapping of motor excitability with single-pulse TMS over the scalp, respectively. We will use a multi-featural visual working memory task involving change detection for dot motion stimuli. Subjects must remember the speed, orientation, and dot density of an initial motion pattern (pattern 1), before identifying the perceived orientation of a second motion pattern (pattern 2). Next, subjects are shown two test patterns (pattern 3 and pattern 4) and asked to select which of the two test patterns is the same pattern that they remembered (where the other pattern on each trial has been altered in one of three visual feature dimensions: either speed, orientation, or dot density). We refer to this as a 2-alternative-forced-choice (2AFC) change detection task, which is used to assess working memory precision (for pattern 1) in this study. Here, we first aim to replicate a known motion repulsion effect whereby subjects mis-judge the direction of pattern 2 as being oriented further away (clockwise or anticlockwise) from the true pattern 2 direction, respective to the angular separation of pattern 2 from pattern 1 (Kang et al., 2012, doi: 10.3758/s13423-011-0126-5). For example, if subjects remember motion pattern 1 with orientation 45 degrees, and are subsequently presented with motion pattern 2 with orientation 75 degrees, subjects are likely to mis-judge the perceived orientation of pattern 2 as being greater than 75 degrees. Second, we will also measure subjects’ individual change detection thresholds independently for three motion feature dimensions: speed, orientation, and dot density (which will be independently titrated throughout the experimental task using adaptive staircases to maintain the difficulty of the task at approximately 79% correct performance in the 2AFC change detection task). We will also collect trial-by-trial confidence ratings for the 2AFC change detection task. We will measure the effects of continuous theta burst stimulation (cTBS) to dlPFC on 1) the magnitude of the motion repulsion effect, 2) change detection stimulus thresholds (i.e. change magnitude required to keep subjects at 75% correct in the 2AFC change detection task), and 3) metacognitive performance (correspondence between confidence and accuracy; see details in below sections), by comparing the relevant metrics pre- and post-stimulation, within an experimental session. We will examine the anatomical specificity of the effects by comparing these outcomes across stimulation sites (area p9-46v/dlPFC compared to M1, where M1 will serve as a control stimulation site).

Search for “Effects Of Continuous Theta Burst Stimulation To Dorsolateral Prefrontal Cortex On The Interaction Between Visual Working Memory And Perception” downloads:

Visit our Downloads Search page to see if downloads are available.

Find “Effects Of Continuous Theta Burst Stimulation To Dorsolateral Prefrontal Cortex On The Interaction Between Visual Working Memory And Perception” in Libraries Near You:

Read or borrow “Effects Of Continuous Theta Burst Stimulation To Dorsolateral Prefrontal Cortex On The Interaction Between Visual Working Memory And Perception” from your local library.

• The WorldCat Libraries Catalog: Find a copy of “Effects Of Continuous Theta Burst Stimulation To Dorsolateral Prefrontal Cortex On The Interaction Between Visual Working Memory And Perception” at a library near you.