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"DTIC ADA581694: Testing Delivery Platforms For New Anticancer TRNA-Based Drugs" and the language of the book is English.


“DTIC ADA581694: Testing Delivery Platforms For New Anticancer TRNA-Based Drugs” Metadata:

  • Title: ➤  DTIC ADA581694: Testing Delivery Platforms For New Anticancer TRNA-Based Drugs
  • Author: ➤  
  • Language: English

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  • Internet Archive ID: DTIC_ADA581694

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"DTIC ADA581694: Testing Delivery Platforms For New Anticancer TRNA-Based Drugs" Description:

The Internet Archive:

Engineered transfer RNAs (tRNA) can be used to reprogram the genetic code and synthesize proteins of interest with new cellular properties. We developed a new class of tRNA mutants that promote numerous and harmful amino acid substitutions upon entering human cells and induce apoptosis. Our objective is to target this tRNA prototype (called killer-tRNA) specifically to cancer cells but sparing healthy blood stem cells and progenitors thereby developing the killer-tRNA as a potential therapeutic agent. Because the killer tRNAs share the exact same feature as all cellular tRNAs, they are undetectable and cannot be cleared by any defense mechanism, thereby constituting a perfect molecular Trojan horse for cell damage and cell death. We aim to test nanocarriers containing killer-tRNAs to human blood cancer cells (acute myeloid leukemia and multiple myeloma) via the high-affinity folate receptors. Since the action of the killer-tRNA is on the synthesis of cellular proteins, it is not restricted to specific stages of cancer. Killer-tRNA can be used to reduce growth of the primary tumor, limit metastatic spread or target tumors at anatomical sites where surgery is difficult to perform.

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  • Internet Archive Link: Archive.org page
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  • Added Date: 2018-09-12 08:08:43
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