"DTIC ADA255735: Interactions Between HIV-Infected Monocytes And The Extracellular Matrix: HIV-Infected Monocytes Secrete Neutral Metalloproteases That Degrade Basement Membrane Protein Matrices," - Information and Links:

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"DTIC ADA255735: Interactions Between HIV-Infected Monocytes And The Extracellular Matrix: HIV-Infected Monocytes Secrete Neutral Metalloproteases That Degrade Basement Membrane Protein Matrices," and the language of the book is English.


“DTIC ADA255735: Interactions Between HIV-Infected Monocytes And The Extracellular Matrix: HIV-Infected Monocytes Secrete Neutral Metalloproteases That Degrade Basement Membrane Protein Matrices,” Metadata:

  • Title: ➤  DTIC ADA255735: Interactions Between HIV-Infected Monocytes And The Extracellular Matrix: HIV-Infected Monocytes Secrete Neutral Metalloproteases That Degrade Basement Membrane Protein Matrices,
  • Author: ➤  
  • Language: English

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  • Internet Archive ID: DTIC_ADA255735

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"DTIC ADA255735: Interactions Between HIV-Infected Monocytes And The Extracellular Matrix: HIV-Infected Monocytes Secrete Neutral Metalloproteases That Degrade Basement Membrane Protein Matrices," Description:

The Internet Archive:

The frequency of human immunodeficieny virus (HIV)-infected monocytes that spread on a model basement membrane was about twofold greater than that of a n equal number of uninfected control cells through the initial 12 to 18 h of culture. By 24 h, virtually all HIV-infected and uninfected control cells spread on the basement membrane gel. The frequency of spread cells in the uninfected control population was 10% of total cells by 12 days. In contrast, 30 to 40% of HIV-infected monocytes remained spread through this time interval and formed a dense interdigitated network of cell processes on and into the gel matrix. Invasion of the basement membrane matrix by HIV-infected monocytes suggested increased secretion of proteases able to digest the gel. Indeed, levels of neutral protease activity in culture fluids from HIV-infected monocytes were significantly higher than those from equal numbers of uninfected control cells. High levels of protease activity in culture fluids of HIV-infected monocytes required productive virus infection and were not observed with cells exposed to T cell-tropic HIV isolates. The predominant protease activity in these cultures was a 92-kd neutral metallogelatinase. HIV-induced changes in monocyte metalloprotease activity may be important for extravasation of infected cells to tissue or for the development of AIDS-associated neuropathology, carcinogenesis, and opportunistic infection.HIV-1, Metalloproteases, Basement membrane, Extracellular matrix.

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  • Added Date: 2018-03-07 14:00:35
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