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The vision of the TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments) Concussion Research Program is to be a global centre of excellence in concussion research that will transform clinical care. This will be achieved by leveraging a learning health system that integrates the application of novel, innovative assessments, including physiological evaluations, fluid biomarkers and advanced neuroimaging. Using extensive, validated, rigorous data-collection methods standardized across clinic sites collected routinely by interdisciplinary providers, we will assess concussion across the spectrum of disease. We will expand our existing large data registry and link with other datasets to answer pressing clinical questions about diagnosis, management, and treatment across the spectrum of concussion. Research participants will consent to the use of de-identified clinical data, collected at 360 Concussion Care, being used for research purposes and shared with research organizations – the CHEO Research Institute and the Ontario Brain Institute (OBI). For Ontario patients, health card number (OHIP) will also be collected to be linked to other research datasets. The TRANSCENDENT concussion research program is primarily funded by the Ontario Brain Institute’s Integrated Discovery Program. Additional funding is provided by the Canada First Research Excellence Fund for the Brain-Heart Interconnectome.