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This article is from Nucleic Acids Research , volume 42 . Abstract The Split Ends (SPEN) protein was originally discovered in Drosophila in the late 1990s. Since then, homologous proteins have been identified in eukaryotic species ranging from plants to humans. Every family member contains three predicted RNA recognition motifs (RRMs) in the N-terminal region of the protein. We have determined the crystal structure of the region of the human SPEN homolog that contains these RRMs—the SMRT/HDAC1 Associated Repressor Protein (SHARP), at 2.0 Å resolution. SHARP is a co-regulator of the nuclear receptors. We demonstrate that two of the three RRMs, namely RRM3 and RRM4, interact via a highly conserved interface. Furthermore, we show that the RRM3–RRM4 block is the main platform mediating the stable association with the H12–H13 substructure found in the steroid receptor RNA activator (SRA), a long, non-coding RNA previously shown to play a crucial role in nuclear receptor transcriptional regulation. We determine that SHARP association with SRA relies on both single- and double-stranded RNA sequences. The crystal structure of the SHARP–RRM fragment, together with the associated RNA-binding studies, extend the repertoire of nucleic acid binding properties of RRM domains suggesting a new hypothesis for a better understanding of SPEN protein functions.

xii, 272 pages ; 21 cm

xii, 272 pages ; 21 cm

xii, 272 pages ; 21 cm

Eric Setzekorn ("Arming East Asia"), Col. L. Scott Lingamfelter, Ret. ("Yanks in Blue Berets"), and Lt. Col. James Lechner, Ret. ("With My Shield") talked about military deterrence in the 21st century. The Association of the United States Army hosted this event in Washington, DC. Sponsor: Association of the U.S. Army

Hadley Media Director Drew Hutchison helped produce this music video by local band Mystics Anonymous using one of the video cameras which are available for sign out from Hadley Media.

Hadley Media Director Drew Hutchison helped produce this music video by local band Mystics Anonymous using one of the video cameras which are available for sign out from Hadley Media.

Hadley Media Director Drew Hutchison helped produce this music video by local band Mystics Anonymous using one of the video cameras which are available for sign out from Hadley Media.

Hadley Media Director Drew Hutchison helped produce this music video by local band Mystics Anonymous using one of the video cameras which are available for sign out from Hadley Media.

Hadley Media Director Drew Hutchison helped produce this music video by local band Mystics Anonymous using one of the video cameras which are available for sign out from Hadley Media.

Eric Setzekorn ("Arming East Asia"), Col. L. Scott Lingamfelter, Ret. ("Yanks in Blue Berets"), and Lt. Col. James Lechner, Ret. ("With My Shield") talked about military deterrence in the 21st century. The Association of the United States Army hosted this event in Washington, DC. Sponsor: Association of the U.S. Army

Eric Setzekorn ("Arming East Asia"), Col. L. Scott Lingamfelter, Ret. ("Yanks in Blue Berets"), and Lt. Col. James Lechner, Ret. ("With My Shield") talked about military deterrence in the 21st century. The Association of the United States Army hosted this event in Washington, DC. Sponsor: Association of the U.S. Army

Eric Setzekorn ("Arming East Asia"), Col. L. Scott Lingamfelter, Ret. ("Yanks in Blue Berets"), and Lt. Col. James Lechner, Ret. ("With My Shield") talked about military deterrence in the 21st century. The Association of the United States Army hosted this event in Washington, DC. Sponsor: Association of the U.S. Army

Afshin Rattansi goes underground on the cost of austerity and a spike in class-consciousness. Journalist and author Mary O’Hara describes a growing sense of social division and the scandalous rise of food poverty in her nationwide study, highlighting deep discontent with an ‘out-of-touch’ political class. We ponder the likely outcomes of the secret TTIP deal between the EU and the US, which will allow foreign multinationals to sue Britain, and offer our round up of media misinformation. Plus, we speak to Mark Bush, director of policy and intelligence at HealthWatch, about the disturbing failure of NHS services to offer effective care plans to vulnerable patients, squandering billions of pounds on unsafe, early discharges.

Eric Setzekorn ("Arming East Asia"), Col. L. Scott Lingamfelter, Ret. ("Yanks in Blue Berets"), and Lt. Col. James Lechner, Ret. ("With My Shield") talked about military deterrence in the 21st century. The Association of the United States Army hosted this event in Washington, DC. Sponsor: Association of the U.S. Army

Eric Setzekorn ("Arming East Asia"), Col. L. Scott Lingamfelter, Ret. ("Yanks in Blue Berets"), and Lt. Col. James Lechner, Ret. ("With My Shield") talked about military deterrence in the 21st century. The Association of the United States Army hosted this event in Washington, DC. Sponsor: Association of the U.S. Army

In this episode of the History Slam, Sean Graham talks with David Borys, author of Civilians at the Sharp End: First Canadian Army Civil Affairs in Northwest Europe. They explore the military’s use of abbreviations, the evolution of civilian treatment by the military, and the colonial elements that influenced Civil Affairs in the Canadian military. […]

In this episode of the History Slam, Sean Graham talks with David Borys, author of Civilians at the Sharp End: First Canadian Army Civil Affairs in Northwest Europe. They explore the military’s use of abbreviations, the evolution of civilian treatment by the military, and the colonial elements that influenced Civil Affairs in the Canadian military. […]

In this episode of the History Slam, Sean Graham talks with David Borys, author of Civilians at the Sharp End: First Canadian Army Civil Affairs in Northwest Europe. They explore the military’s use of abbreviations, the evolution of civilian treatment by the military, and the colonial elements that influenced Civil Affairs in the Canadian military. […]

Eric Setzekorn ("Arming East Asia"), Col. L. Scott Lingamfelter, Ret. ("Yanks in Blue Berets"), and Lt. Col. James Lechner, Ret. ("With My Shield") talked about military deterrence in the 21st century. The Association of the United States Army hosted this event in Washington, DC. Sponsor: Association of the U.S. Army

David Wearing joins me to discuss the defence, security and international trade policies of Labour and the Conservatives, and why the election result is a matter of life and death for many people beyond Britain's borders.

Eric Setzekorn ("Arming East Asia"), Col. L. Scott Lingamfelter, Ret. ("Yanks in Blue Berets"), and Lt. Col. James Lechner, Ret. ("With My Shield") talked about military deterrence in the 21st century. The Association of the United States Army hosted this event in Washington, DC. Sponsor: Association of the U.S. Army

The Low End Theory - 46 - Jim Sharp

The Low End Theory - 46 - Jim Sharp

296 pages ; 25 cm

296 pages ; 25 cm

296 pages ; 25 cm

Eric Setzekorn ("Arming East Asia"), Col. L. Scott Lingamfelter, Ret. ("Yanks in Blue Berets"), and Lt. Col. James Lechner, Ret. ("With My Shield") talked about military deterrence in the 21st century. The Association of the United States Army hosted this event in Washington, DC. Sponsor: Association of the U.S. Army

Eric Setzekorn ("Arming East Asia"), Col. L. Scott Lingamfelter, Ret. ("Yanks in Blue Berets"), and Lt. Col. James Lechner, Ret. ("With My Shield") talked about military deterrence in the 21st century. The Association of the United States Army hosted this event in Washington, DC. Sponsor: Association of the U.S. Army

   This is a shocking book! It tells what it was really like to be at the front end of the 'big stick' in World War II. In any war, it is only a minority of men who end up as combat soldiers, 'at the sharp end', where they have to shoot and be shot at. But it is their experiences that are the most intense and reveal most directly what war is actually like. John Ellis' outstanding book offers readers the chance to live and breath what it felt like to be up front in WW II.    Ellis has drawn together the testimony of men who fought with British, Commonwealth, and American armies in all theaters of the war, Western Europe to Burma, North Africa to the Pacific. He uses these eyewitnesses to explain how they were trained, the different landscapes and climate in which they fought, their attitudes and aspirations, how they relaxed, what they wore and what they ate, even how they killed and how they died, in short, how they reacted to the experience of battle.    Ellis' empathy and affection for the 'ordinary' soldier is clearly demonstrated across the pages. He does a real service to them by adding a voice to explain and interpret their endurance through unimaginable circumstances and the final personal cost each one paid, especially the survivors.      Ellis' book will be of great interest to anyone wishing to understand how their fathers or grandfathers felt, caught up in the biggest conflict known to man. Forget about war movies, read this book.

   This is a shocking book! It tells what it was really like to be at the front end of the 'big stick' in World War II. In any war, it is only a minority of men who end up as combat soldiers, 'at the sharp end', where they have to shoot and be shot at. But it is their experiences that are the most intense and reveal most directly what war is actually like. John Ellis' outstanding book offers readers the chance to live and breath what it felt like to be up front in WW II.    Ellis has drawn together the testimony of men who fought with British, Commonwealth, and American armies in all theaters of the war, Western Europe to Burma, North Africa to the Pacific. He uses these eyewitnesses to explain how they were trained, the different landscapes and climate in which they fought, their attitudes and aspirations, how they relaxed, what they wore and what they ate, even how they killed and how they died, in short, how they reacted to the experience of battle.    Ellis' empathy and affection for the 'ordinary' soldier is clearly demonstrated across the pages. He does a real service to them by adding a voice to explain and interpret their endurance through unimaginable circumstances and the final personal cost each one paid, especially the survivors.      Ellis' book will be of great interest to anyone wishing to understand how their fathers or grandfathers felt, caught up in the biggest conflict known to man. Forget about war movies, read this book.

215p. ; 22cm

215p. ; 22cm

215p. ; 22cm

215p. ; 22cm

215p. ; 22cm

"A Baen books original"--T.p. verso

"A Baen books original"--T.p. verso

"A Baen books original"--T.p. verso

"A Baen books original"--T.p. verso

xiii, 270 pages : 24 cm

xiii, 270 pages : 24 cm

xiii, 270 pages : 24 cm

206 pages ; 24 cm

206 pages ; 24 cm

1Life of Kit Carson

By Edward S. Ellis

Christopher Carson, or as he was familiarly called, Kit Carson, was a man whose real worth was understood only by those with whom he was associated or who closely studied his character. He was more than hunter, trapper, guide, Indian agent and Colonel in the United States Army....His lot was cast on the extreme western frontier, where, when but a youth, he earned the respect of the tough and frequently lawless men with whom he came in contact. Integrity, bravery, loyalty to friends, marvelous quickness in making right decisions, in crisis of danger, consummate knowledge of woodcraft, a leadership as skillful as it was daring; all these were distinguishing traits in the composition of Carson and were the foundations of the broader fame which he acquired as the friend and invaluable counselor of Fremont, the Pathfinder, in his expeditions across the Rocky Mountains. (Summary from the Introduction)

LibriVox volunteers bring you 11 recordings of The Twelve Months by George Ellis. This was the Weekly Poetry project for January 24th, 2010.

3Studies in the Psychology of Sex, Volume 1

By Havelock Ellis

The first of six volumes, this volume covers in extensive detail the topics of "The Evolution of Modesty", "The Phenomena of Sexual Periodicity", and "Auto-Eroticism". Written as an anthropological and psychological study from the point of view of Havelock, the famous British sexologist of the late 19th century, who was also a physician and social reformer. (Summary by Tim Ferreira)

4Studies in the Psychology of Sex, Volume 2

By Havelock Ellis

The second of six volumes, this volume covers in extensive detail the topic of "Sexual Inversion", or homosexuality to give it a more current name. Written as an anthropological and psychological study from the point of view of Havelock, the famous British sexologist of the late 19th century, who was also a physician and social reformer. (Summary by Tim Ferreira and John Fricker)

5Astounding Stories 02, February 1930

By Hugh B. Cave, Charles Willard Diffin, Sophie Wenzel Ellis, Captain S. P. Meek, Anthony Pelcher, Victor Rousseau and Harl Vincent

This is the second issue of the classic science fiction Astounding Magazine. It contains the finale of The Beetle Horde by Victor Rousseau, as well as stories by Harl Vincent, Charles Willard Diffin, Hugh B. Cave, Sophie Wenzel Ellis, Sterner St. Paul, Anthony Pelcher and Captain S. P. Meek. (Summary by Alan Winterrowd)

6Bill Biddon, Trapper

By Edward S. Ellis

Our young hero and his companion plan to make their fortunes in the California gold rush. Having made their way to Missouri, they join a wagon train headed for the famed Oregon Trail, but being carefree and adventuresome young men, they are not happy relaxing by the fireside of an evening. Encounters with animals, raging rivers and "Injuns" keep them interested in their voyage, but what will the Pacific Coast hold for them? - Summary by Lynne Thompson

7English Girl's First Impressions of Burmah

By Beth Ellis

An English Girl's First Impressions of Burmah, by Beth Ellis, is a well-edited, turn-of-the-century journal documenting a young woman’s visit to Burma. The account documents her ocean voyage to Rangoon, and her stay in a small, jungle-embedded, European community in Remyo. The author, who travelled to Asia alone to visit her brother, is quick to laugh at her own exaggerated fears. She gives us a glimpse into the less-than-glamorous lives to Myanmar’s British occupiers. The book was published in 1899, just thirteen years after the conclusion of the third Anglo-Burmese war, when Britain took formal control of Myanmar and made it a province of India. (Summary by Carol Fullerton-Samsel)

8Astounding Stories 12, December 1930

By Charles Willard Diffin, Sophie Wenzel Ellis, Captain S. P. Meek, David R. Sparks and Harl Vincent

This issue includes "Slaves of the Dust" by Sophie Wenzel Ellis, Part B of "The Pirate Planet" by Charles W. Diffin, "The Sea Terror" by Captain S. P. Meek, "Gray Denim" by Harl Vincent, and "The Ape-Men of Xlotli" by David R. Sparks. - Summary by Bill Boerst

9Steam Man of the Prairies

By Edward S. Ellis

Ethan Hopkins and Mickey McSquizzle-a "Yankee" and an "Irishman"-encounter a colossal, steam-powered man in the American prairies. This steam-man was constructed by Johnny Brainerd, a teenaged boy, who uses the steam-man to carry him in a carriage on various adventures. - Summary by Wikipedia

10In the Pecos Country

By Edward S. Ellis

Edward Sylvester Ellis was a major American author during the era of inexpensive fiction of the nineteenth century (dime novels). Because he wrote under dozens of pseudonyms, as well as under his own name, it is virtually impossible to know exactly how many books he wrote, but it is believed to be in the hundreds. He specialized in boys' stories, inspirational biography, and history for both children and adults. (From FictionDB.com) This is a western, set in the Pecos River valley in the late 19th century, post Civil War era.

11Cave In the Mountain

By Edward S. Ellis

Edward Sylvester Ellis was a major American author during the era of inexpensive fiction of the nineteenth century (dime novels). Because he wrote under dozens of pseudonyms, as well as under his own name, it is virtually impossible to know exactly how many books he wrote, but it is believed to be in the hundreds. He specialized in boys' stories, inspirational biography, and history for both children and adults. (From FictionDB.com) This is a western, set in the Pecos River valley in the late 19th century, post Civil War era. This is the sequel to "In the Pecos Country", and the second half of the same story, begun in that book.

12Little Bit of Fluff

By Walter W. Ellis

According to the website www.stagebeauty.net, this is the 5th longest running play ever, with over 1200 original performances. Like Charley's Aunt (number 2 on the list and released by Librivox earlier in 2018), this also is a farce. An insurance investigator, a possible fraudulent injury claim, a lost necklace, an aged aunt with a more than passing resemblance to someone else, and of course, that Little Bit of Fluff - all conspire to cause great confusion. - Summary by ToddHW <BR><BR>Cast list:<BR> JOHN AYERS: <a href="https://librivox.org/reader/10789">Tomas Peter</a><br> BERTRAM TULLY, His friend: <a href="https://librivox.org/reader/13072">Campbell Schelp</a><br> NIXON TRIPPETT, Inspector of Claims for the Motor ’Bus Company: <a href="https://librivox.org/reader/7079">Chuck Williamson</a><br> DR. BIGLAND, Also for the Motor ’Bus Company: <a href="https://librivox.org/reader/6754">ToddHW</a><br> PAMELA, Mrs. John Ayers: <a href="https://librivox.org/reader/12923">EmmaHatton</a><br> MAMIE SCOTT, From the Five Hundred Club: <a href="https://librivox.org/reader/11790">TJ Burns</a><br> AUNT HANNAH, Mr. Tully’s Aunt: <a href="https://librivox.org/reader/4174">Availle</a><br> URSULA, Mr. Tully’s Maid: <a href="https://librivox.org/reader/12900">Aleacia Messiah</a><br> CHALMERS, Mrs. Ayers’ Maid: <a href="https://librivox.org/reader/11417">Eva Davis</a><br> Stage Directions: <a href="https://librivox.org/reader/13128">Elisabeth Holland</a><br> Edited by: <a href="https://librivox.org/reader/6754">ToddHW</a>

A love and adventure story with the West African jungle as the main backdrop. We gain some insight into the spiritual influence of African social institutions and conditions of African inner life. (kirk202)

The psychological and anthropological character of genius in the British Isles was investigated by Ellis. Citing and collating an extensive source of information from the Dictionary of National Biography, many pieces of informational are discussed, including the ancestral heritage, geographical distribution, professions, and health and morbidity of the most the most preeminent men and women of the time. This work also promotes his theory that large cities are not only counterproductive to the development of high achievers, but detrimental to national health. (Summary by Leon Harvey)

15Story of Red Feather

By Edward S. Ellis

The fierce chieftain Red Feather is leading a raiding party of Sioux across the Montana frontier, and the Clarendon homestead is directly in his path! Melville must escape the siege with his little sister Dot, and gets some unexpected help along the way. (Summary by Mira Williams)

Vol. 1 of Diaries and letters of the young Fanny Burney. The diaries give a lively and accurate account of her experiences in the literary and courtly worlds of Georgian England. The Volume also contains a selection from her correspondence and from the journals of her sisters Susan and Charlotte Burney. (Summary by barbara2)

17Studies in the Psychology of Sex, Volume 3

By Havelock Ellis

Volume 3: Analysis of the Sexual Impulse; Love and Pain In the study of Love and Pain I have discussed the sources of those aberrations which are commonly called, not altogether happily, "sadism" and "masochism." Here we are brought before the most extreme and perhaps the most widely known group of sexual perversions. I have considered them from the medico-legal standpoint, because that has already been done by other writers whose works are accessible. I have preferred to show how these aberrations may be explained; how they may be linked on to normal and fundamental aspects of the sexual impulse; and, indeed, in their elementary forms, may themselves be regarded as normal. In some degree they are present, in every case, at some point of sexual development; their threads are subtly woven in and out of the whole psychological process of sex. I have made no attempt to reduce their complexity to a simplicity that would be fallacious. I hope that my attempt to unravel these long and tangled threads will be found to make them fairly clear. In the third study, on The Sexual Impulse in Women, we approach a practical question of applied sexual psychology, and a question of the first importance. No doubt the sex impulse in men is of great moment from the social point of view. It is, however, fairly obvious and well understood. The impulse in women is not only of at least equal moment, but it is far more obscure. The natural difficulties of the subject have been increased by the assumption of most writers who have touched it—casually and hurriedly, for the most part—that the only differences to be sought in the sexual impulse in man and in woman are quantitative differences. I have pointed out that we may more profitably seek for qualitative differences, and have endeavored to indicate such of these differences as seem to be of significance. - Summary by Havelock Ellis

The diaries give a lively and accurate account of the author's experiences in the literary and courtly worlds of Georgian England. Summary by barbara2

British Army officer and ethnographer AB Ellis was known for his writings on West Africa. His final publication takes an anthropological magnifying glass to the lives of Yoruba peoples in west Africa. The book’s subtitle reads: " their religion, manners, customs, laws, language, etc : with an appendix containing a comparison of the Tshi, Gã, Ęwe, and Yoruba languages". The following recording is selected readings from his fifteen chapters: Chief Gods, Measurements of Time, Ceremonies at Birth, Marriage and Death and Conclusions. (Summary by Faith Abíọ́lá-Ellison)

Escape into another exciting issue of the influential pulp magazine The Thrill Book! In this issue, beware the "Vengeance of Vishnu", an exotic mystery! Feel your blood chill to the ghost story "The Unseen Seventh"! Cast off for adventure in the sea stories "This Way Out" and "The Sargasso Sea"! Gaze in awe to the weird experiment in soul transference of "The Borderland Bridge"! Also in this issue is the second part of the World War I spy thriller "Strasbourg Rose"! All this and more await you! - Summary by Ben Tucker

From the darkest corners of the Amazon to the idyllic island paradise of Borneo, the early years of Weird Tales were chocked full of dread tales of jungle terrors. Fierce beasts, deadly cannibals and all other manner of unknown horrors await beneath the lush canopies of trees. Even if you aren't foolish enough to brave the dangers of the jungle, the jungle may come to you instead! Join us for another fright-filled collection of stories from the celebrated halls of Weird Tales magazine! - Summary by Ben Tucker

22Studies in the Psychology of Sex Volume 4

By Havelock Ellis

The fourth of six volumes, this volume delves into how sensory stimuli: specifically through touch, smell, hearing, and vision, affect sexual attraction and choice in humans. Ellis aims to explore the psychological dimensions of sexual selection, underlining how these sensory interactions contribute to the complex phenomena of love and attraction. Written as an anthropological and psychological study from the point of view of Havelock, the famous British sexologist of the late 19th century, who was also a physician and social reformer. - Summary by Tim Ferreira and Jessie Percival