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Background and Objective: Along with erythrocytes, the Kidd glycoprotein exists in the kidney, where it enables the kidney to accumulate an elevated urea concentration, which is required for the kidney to produce concentrated urine.

This article is from North American Journal of Medical Sciences , volume 2 . Abstract Background:: The markers of renal function test assess the normal functioning of kidneys. These markers may be radioactive and non radioactive. They indicate the glomerular filtration rate, concentrating and diluting capacity of kidneys (tubular function). If there is an increase or decrease in the valves of these markers it indicates dysfunction of kidney. Aim:: The aim of this review is to compare and analyze the present and newer markers of renal function tests which help in diagnosis of clinical disorders. Material & Methods:: An extensive literature survey was done aiming to compare and compile renal function tests makers required in diagnosis of diseases. Results:: Creatinine, urea, uric acid and electrolytes are makers for routine analysis whereas several studies have confirmed and consolidated the usefulness of markers such as cystatin C and β-Trace Protein. Conclusion:: We conclude that further investigation is necessary to define these biomarkers in terms of usefulness in assessing renal function.