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The work presented in this paper examined the criteria of Eurocode 2 (EC 2) (2004) for the design of reinforced concrete short columns subjected to axial loads and bending moments using First Order Reliability method (FORM).Individual design variables of the columns were considered random with known probability distributions. Computations of design safety indices were carried as described by Low and Tang (2007). Interaction curves were plotted considering varying safety indices of the columns. The choice of a target reliability index was made to correspond with values recommended by Joint Committee on Structural Safety (JCSS, 2001). A design example was included to demonstrate the applicability of the developed reliability-based interaction as against the current EC 2 design charts. It was shown that considering the same loading and geometrical conditions of the column, the reliability-based procedure gave higher steel reinforcements at target safety indices of 2.5, 3.0, 4.0 and 5.0; and are safer than the deterministic design.