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This article is from Systematic Reviews , volume 3 . Abstract Background: Patients undergoing renal transplant procedures require multi-agent immunosuppressive regimens both short term (induction phase) and long term (maintenance phase) to minimize the risk of organ rejection. There are several drug classes and agents for immunosuppression. Use of these agents may increase the risk of different harms including not only infections, but also malignancies including post-transplant lymphoproliferative disorder. There is a need to identify which regimens minimize the risk of such outcomes. The objective of this systematic review and network meta-analysis of randomized and observational studies is to explore whether certain modern regimens of immunosuppression used to prevent organ rejection in renal transplant patients are associated with an increased risk of post-transplant lymphoproliferative disorder and other malignancies. Methods/design: ‘Modern’ regimens were defined to be those evaluated in controlled studies beginning in 1990 or later. An electronic literature search of Medline, Embase and the Cochrane Central Register of Controlled Trials has been designed by an experienced information specialist and peer reviewed by a second information specialist. Study selection and data collection will be performed by two reviewers. The outcomes of interest will include post-transplant lymphoproliferative disorder and other incident forms of malignancy occurring in adult renal transplant patients. Network meta-analyses of data from randomized and observational studies will be performed where judged appropriate based on a review of the clinical and methodological features of included studies. A sequential approach to meta-analysis will be used to combine data from different designs. Discussion: Our systematic review will include both single-agent and multi-agent modern pharmacotherapy regimens in patients undergoing renal transplantation. It will synthesize malignancy outcomes. Our work will also add to the development of methods for network meta-analysis across study designs to assess treatment safety. Trial registration: PROSPERO Registration Number: CRD42013006951

Application of modern network theory to analysis of manned systems

The effects of different root-end filling materials in modern surgical endodontic treatment remained debatable. Therefore, we conducted a network meta-analysis to provide the evidence of effects of different root-end filling materials in modern surgical endodontic treatment.

The effects of different root-end filling materials in modern surgical endodontic treatment remained debatable. Therefore, we conducted a network meta-analysis to provide the evidence of effects of different root-end filling materials in modern surgical endodontic treatment.

Through technical analysis and comparison of authentication modes and architecture of commonly used network accounting technology such as PPPoE + Radius, DHCP + WEB + Radius, 802.1X + Radius, Kerberos and SSO, it is revealed in this paper that Kerberos as a new mode is suitable for the application of Web network system identity Authentication; while in many cases SSO can access all the mutually trusted application system by means of a single login; and in modern broadband Ethernet access, optimized IEEE 802.1x protocol + Radius server authentication mode is recommended, which can solve the bottleneck problem of the traditional authentication methods such as PPPoE and Web / Portal.

Through technical analysis and comparison of authentication modes and architecture of commonly used network accounting technology such as PPPoE + Radius, DHCP + WEB + Radius, 802.1X + Radius, Kerberos and SSO, it is revealed in this paper that Kerberos as a new mode is suitable for the application of Web network system identity Authentication; while in many cases SSO can access all the mutually trusted application system by means of a single login; and in modern broadband Ethernet access, optimized IEEE 802.1x protocol + Radius server authentication mode is recommended, which can solve the bottleneck problem of the traditional authentication methods such as PPPoE and Web / Portal.

Modern network theory applications to analysis of complex systems

Modern network theory applications to analysis of complex systems