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This scoping review aims to map the existing scientific evidence on the use of the Molecular Adsorbent Recirculating System (MARS) in patients with trauma-induced acute liver failure (ALF) or acute-on-chronic liver failure (ACLF). The review follows the methodology outlined by the Joanna Briggs Institute (JBI) and adheres to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist. The original protocol was developed for a systematic review and registered in PROSPERO (CRD420251041707), but was subsequently adapted into a scoping review after identifying a limited number of eligible studies, small sample sizes, and significant clinical heterogeneity. The main objectives of this review are to: Summarize available data on the clinical use of MARS in trauma patients. Identify reported outcomes including survival, liver function recovery, biochemical responses, and complications. Explore gaps in the literature to guide future research efforts in this area. Seven studies were ultimately included. The results are synthesized narratively and thematically. Findings are intended to support clinicians and researchers in evaluating the feasibility, safety, and indications of MARS in trauma-related liver failure.