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Two hospitalized rapidly cycling manic-depressive patients underwent daily ratings by nursing staff using the Overall-Gorham Brief Psychiatric Rating Scale and daily 24-hour urine collections for assay of volume, osmolality, 17- hydroxycorticosteroids, vanillylmandelic acid, kynurenine, and indoleacetic acid. Multivariate analyses of the BPRS and biochemical data. The BPRS yields useful day-to-day measures of changes in psychopathology in manic-depressive illness and delineates specific manic and depressive symptom clusters for each patient. Regression equations for the biochemical measures were constructed to yield a 'predicted' contrast function correlating best with BPRS contrast function for each patient. Time-series plots were made with BPRS contrast function and biochemical 'predicted' contrast function together, and with BPRS and biochemical discriminant combinations together. These time-series plots generally revealed that shifts in the biochemical domain lagged several days behind shifts in the BPRS domain. It appears that the urine biochemical variables were peripheral reflections of alterations in total body metabolic pathways secondary to both specific central nervous system influences, such as ACTH release, and non-specific changes, such as level of motor activity, occurring with shifts between mania and depression. It does not appear that the urine variables measured in this study reflected any biochemical CNS changes antecedent to shifts in manifest psychopathology during the manic-depressive cycle.

Two hospitalized rapidly cycling manic-depressive patients underwent daily ratings by nursing staff using the Overall-Gorham Brief Psychiatric Rating Scale and daily 24-hour urine collections for assay of volume, osmolality, 17- hydroxycorticosteroids, vanillylmandelic acid, kynurenine, and indoleacetic acid. Multivariate analyses of the BPRS and biochemical data. The BPRS yields useful day-to-day measures of changes in psychopathology in manic-depressive illness and delineates specific manic and depressive symptom clusters for each patient. Regression equations for the biochemical measures were constructed to yield a 'predicted' contrast function correlating best with BPRS contrast function for each patient. Time-series plots were made with BPRS contrast function and biochemical 'predicted' contrast function together, and with BPRS and biochemical discriminant combinations together. These time-series plots generally revealed that shifts in the biochemical domain lagged several days behind shifts in the BPRS domain. It appears that the urine biochemical variables were peripheral reflections of alterations in total body metabolic pathways secondary to both specific central nervous system influences, such as ACTH release, and non-specific changes, such as level of motor activity, occurring with shifts between mania and depression. It does not appear that the urine variables measured in this study reflected any biochemical CNS changes antecedent to shifts in manifest psychopathology during the manic-depressive cycle.

Two hospitalized rapidly cycling manic-depressive patients underwent daily ratings by nursing staff using the Overall-Gorham Brief Psychiatric Rating Scale and daily 24-hour urine collections for assay of volume, osmolality, 17- hydroxycorticosteroids, vanillylmandelic acid, kynurenine, and indoleacetic acid. Multivariate analyses of the BPRS and biochemical data. The BPRS yields useful day-to-day measures of changes in psychopathology in manic-depressive illness and delineates specific manic and depressive symptom clusters for each patient. Regression equations for the biochemical measures were constructed to yield a 'predicted' contrast function correlating best with BPRS contrast function for each patient. Time-series plots were made with BPRS contrast function and biochemical 'predicted' contrast function together, and with BPRS and biochemical discriminant combinations together. These time-series plots generally revealed that shifts in the biochemical domain lagged several days behind shifts in the BPRS domain. It appears that the urine biochemical variables were peripheral reflections of alterations in total body metabolic pathways secondary to both specific central nervous system influences, such as ACTH release, and non-specific changes, such as level of motor activity, occurring with shifts between mania and depression. It does not appear that the urine variables measured in this study reflected any biochemical CNS changes antecedent to shifts in manifest psychopathology during the manic-depressive cycle.

Two hospitalized rapidly cycling manic-depressive patients underwent daily ratings by nursing staff using the Overall-Gorham Brief Psychiatric Rating Scale and daily 24-hour urine collections for assay of volume, osmolality, 17- hydroxycorticosteroids, vanillylmandelic acid, kynurenine, and indoleacetic acid. Multivariate analyses of the BPRS and biochemical data. The BPRS yields useful day-to-day measures of changes in psychopathology in manic-depressive illness and delineates specific manic and depressive symptom clusters for each patient. Regression equations for the biochemical measures were constructed to yield a 'predicted' contrast function correlating best with BPRS contrast function for each patient. Time-series plots were made with BPRS contrast function and biochemical 'predicted' contrast function together, and with BPRS and biochemical discriminant combinations together. These time-series plots generally revealed that shifts in the biochemical domain lagged several days behind shifts in the BPRS domain. It appears that the urine biochemical variables were peripheral reflections of alterations in total body metabolic pathways secondary to both specific central nervous system influences, such as ACTH release, and non-specific changes, such as level of motor activity, occurring with shifts between mania and depression. It does not appear that the urine variables measured in this study reflected any biochemical CNS changes antecedent to shifts in manifest psychopathology during the manic-depressive cycle.

Two hospitalized rapidly cycling manic-depressive patients underwent daily ratings by nursing staff using the Overall-Gorham Brief Psychiatric Rating Scale and daily 24-hour urine collections for assay of volume, osmolality, 17- hydroxycorticosteroids, vanillylmandelic acid, kynurenine, and indoleacetic acid. Multivariate analyses of the BPRS and biochemical data. The BPRS yields useful day-to-day measures of changes in psychopathology in manic-depressive illness and delineates specific manic and depressive symptom clusters for each patient. Regression equations for the biochemical measures were constructed to yield a 'predicted' contrast function correlating best with BPRS contrast function for each patient. Time-series plots were made with BPRS contrast function and biochemical 'predicted' contrast function together, and with BPRS and biochemical discriminant combinations together. These time-series plots generally revealed that shifts in the biochemical domain lagged several days behind shifts in the BPRS domain. It appears that the urine biochemical variables were peripheral reflections of alterations in total body metabolic pathways secondary to both specific central nervous system influences, such as ACTH release, and non-specific changes, such as level of motor activity, occurring with shifts between mania and depression. It does not appear that the urine variables measured in this study reflected any biochemical CNS changes antecedent to shifts in manifest psychopathology during the manic-depressive cycle.

Two hospitalized rapidly cycling manic-depressive patients underwent daily ratings by nursing staff using the Overall-Gorham Brief Psychiatric Rating Scale and daily 24-hour urine collections for assay of volume, osmolality, 17- hydroxycorticosteroids, vanillylmandelic acid, kynurenine, and indoleacetic acid. Multivariate analyses of the BPRS and biochemical data. The BPRS yields useful day-to-day measures of changes in psychopathology in manic-depressive illness and delineates specific manic and depressive symptom clusters for each patient. Regression equations for the biochemical measures were constructed to yield a 'predicted' contrast function correlating best with BPRS contrast function for each patient. Time-series plots were made with BPRS contrast function and biochemical 'predicted' contrast function together, and with BPRS and biochemical discriminant combinations together. These time-series plots generally revealed that shifts in the biochemical domain lagged several days behind shifts in the BPRS domain. It appears that the urine biochemical variables were peripheral reflections of alterations in total body metabolic pathways secondary to both specific central nervous system influences, such as ACTH release, and non-specific changes, such as level of motor activity, occurring with shifts between mania and depression. It does not appear that the urine variables measured in this study reflected any biochemical CNS changes antecedent to shifts in manifest psychopathology during the manic-depressive cycle.

Several biochemical parameters were investigated in an attempt to elucidate changing patterns of physiologic activity with changes in mood in manic-depressive illness. Two hospitalized rapidly cycling manic-depressive patients underwent daily clinical ratings of mood, daily measurements of blood pressure and weight, and daily 24-hour urine collections for creatinine, 17- hydroxycorticosteroids (17-OHCS) vanillylmandelic acid (VMA), kynurenine, and indole-3-acetic acid (IAA). Mean daily excretion was calculated for each variable measured for each clinical phase. The following results were obtained and discussed: (1) Urine volume and creatinine excretion were lower during depression, most likely on the basis of reduced fluid intake. (2) VMA excretion was higher during mania and correlated with level of physical activity. (3) Kynurenine excretion was lower during depression, possibly on the basis of heightened metabolism of kynurenine during depression. (4) IAA excretion was increased during depression, although variations in daily levels during all phases were considerable. The multiple biochemical variables reported suggest both inter-subject and intra-subject differences in patterns of physiologic activity in patients with rapidly cycling mood disorders. The results highlight the difficulty inherent in inferring central mechanisms from the measurement of peripheral variables.

Several biochemical parameters were investigated in an attempt to elucidate changing patterns of physiologic activity with changes in mood in manic-depressive illness. Two hospitalized rapidly cycling manic-depressive patients underwent daily clinical ratings of mood, daily measurements of blood pressure and weight, and daily 24-hour urine collections for creatinine, 17- hydroxycorticosteroids (17-OHCS) vanillylmandelic acid (VMA), kynurenine, and indole-3-acetic acid (IAA). Mean daily excretion was calculated for each variable measured for each clinical phase. The following results were obtained and discussed: (1) Urine volume and creatinine excretion were lower during depression, most likely on the basis of reduced fluid intake. (2) VMA excretion was higher during mania and correlated with level of physical activity. (3) Kynurenine excretion was lower during depression, possibly on the basis of heightened metabolism of kynurenine during depression. (4) IAA excretion was increased during depression, although variations in daily levels during all phases were considerable. The multiple biochemical variables reported suggest both inter-subject and intra-subject differences in patterns of physiologic activity in patients with rapidly cycling mood disorders. The results highlight the difficulty inherent in inferring central mechanisms from the measurement of peripheral variables.

Several biochemical parameters were investigated in an attempt to elucidate changing patterns of physiologic activity with changes in mood in manic-depressive illness. Two hospitalized rapidly cycling manic-depressive patients underwent daily clinical ratings of mood, daily measurements of blood pressure and weight, and daily 24-hour urine collections for creatinine, 17- hydroxycorticosteroids (17-OHCS) vanillylmandelic acid (VMA), kynurenine, and indole-3-acetic acid (IAA). Mean daily excretion was calculated for each variable measured for each clinical phase. The following results were obtained and discussed: (1) Urine volume and creatinine excretion were lower during depression, most likely on the basis of reduced fluid intake. (2) VMA excretion was higher during mania and correlated with level of physical activity. (3) Kynurenine excretion was lower during depression, possibly on the basis of heightened metabolism of kynurenine during depression. (4) IAA excretion was increased during depression, although variations in daily levels during all phases were considerable. The multiple biochemical variables reported suggest both inter-subject and intra-subject differences in patterns of physiologic activity in patients with rapidly cycling mood disorders. The results highlight the difficulty inherent in inferring central mechanisms from the measurement of peripheral variables.

Includes bibliographical references (p. [271]-353) and index

Includes bibliographical references (p. [271]-353) and index

Includes bibliographical references (p. [271]-353) and index

Includes bibliographical references (p. [271]-353) and index

Includes bibliographical references (p. [271]-353) and index

Includes bibliographical references (p. [271]-353) and index

Includes bibliographical references (p. [271]-353) and index

Includes bibliographical references (p. [271]-353) and index

Includes bibliographical references (p. [271]-353) and index

Includes bibliographical references (p. [271]-353) and index

Includes bibliographical references (p. [271]-353) and index

27

The edition of the book published in 1921 explored extensively the reasons why Mormons were not accepted ("are" at the time of publication) into the Masonic Lodges. (Summary by Chiquito J. Crasto)

2Caves of Fear

By Harold L. Goodwin

Entry in the Rick Brant series by Goodwin under the name John Blaine, which began in 1947. 'Rick and Scotty travel to the Himalayas again, this time to stop nuclear materials from falling into the wrong hands.' says Wikipedia. - Summary by BellonaTimes

3Rip Foster Rides the Gray Planet

By Harold L. Goodwin

"Foster, Lieutenant, R. I. P.," blared the voice horn, and five minutes later Rip Foster was off into space on an assignment more exciting than any he had ever imagined. He could hardly believe his ears. Could a green young Planeteer, just through his training, possibly carry out orders like these? Sunny space, what a trick it would be! From the moment Rip boards the space ship Scorpius there is a thrill a minute. He and his nine daring Planeteers must cope with the merciless hazing of the spacemen commanding the ship, and they must outwit the desperate Connies, who threaten to plunge all of space into war. There are a thousand dangers to be faced in high vacuum—and all of this while carrying out an assignment that will take every reader's breath away. - Summary by Original book cover

4Boy Scouts in Russia

By Harold L. Goodwin

Thrown out of Russia by a powerful relative, a young American Boy Scout, Fred Waring, meets his Russian cousin, Boris Suvaroff, and together they discover the secrets of the advancing German army. Through perilous escapes, secret passages, and being captured as a spy (by both sides), they deliver their information to Russian intelligence. But Fred now has to face an obstacle even bigger than he had realized. <br> John Blaine is a pseudonym of Harold L. Goodwin. (Kangaroo)

5Smugglers' Reef

By Harold L. Goodwin

Seventh entry in the Rick Brant Science Mystery Adventure series has Rick and buddy Scott using infrared technology on the trail of smuggling no-goodniks in the vicinity of Spindrift Island, Rick's home and location of his dad's laboratory, off the New Jersey & New York coast. - Summary by Matt Pierard

6Flying Stingaree

By Harold L. Goodwin

First published in 1963, this is another adventure in the Rick Brant Science series, set on Chesapeake Bay and involving mysterious, sting ray-shaped drones and missing persons. (synopsis by Matt Pierard)

7Chronicles of America Volume 07 - Dutch and English on the Hudson

By Maud Wilder Goodwin

Geography is the maker of history. The course of Dutch settlement in America was predetermined by a river which runs its length of a hundred and fifty miles from the mountains to the sea through the heart of a fertile country and which offers a natural highway for transportation of merchandise and for communication between colonies. No man, however, could foresee the development of the Empire State when, on that memorable September day in 1609, a small Dutch yacht named the Halve Maene or Half Moon, under the command of Captain Henry Hudson, slipped in past the low hook of sand in front of the Navesink Heights, and sounded her way to an anchorage in what is now the outer harbor of New York. (from Chapter 1)

8Blue Ghost Mystery

By Harold L. Goodwin

When the ghost of a Civil War soldier, killed visiting his sweetheart across enemy lines, comes back to haunt the Virginian locals at an old mine, Rick Brant and his ex-marine colleague Scotty decide to investigate. - Summary by John Walker

9Wailing Octopus

By Harold L. Goodwin

Rick and Scotty fly off to the Caribbean, along with Drs. Briotti and Zircon, in search of pirate treasure. They soon become entangled with foreign spies and a hurricane and Steve Ames and the U.S. Navy, and it's a non-stop race to the treasure! - Summary by sjmarky

A discourse of the several parts which the three persons of the Godhead bear in the accomplishment of our salvation, and that they have taken on them several works appropriate to them therein.—And the distribution of our salvation into three parts, according to the number of the three persons, and the part which each of them have taken therein, viz., the Father in election, the Son in redemption and justification, the Holy Ghost in sanctification and application. - Summary by Preface

A Treatise demonstrating the Gracious Disposition and Tender Affection of Christ, in his Human Nature now in Glory, unto his Members, under all sorts of Infirmities, either of Sin or Misery. - Summary from Title Page

Of the More Excellent Glory and Power Which Accompanies His Promulgation of the Gospel, Than Did Accompany the Giving of the Law on Mount Sinai - Summary from Subtitle

13Anthology of Modern Indian Poetry

By Gwendoline Goodwin

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. "The call of Youth in India is a hot young call, trumpeting down the ages through a maze of polytheistic tribute, and emerging in the twentieth century with some of its original clearness of sound drowned by a Gargantuan thunder of Western drums. The Indian poet of to-day is torn, like the Indian painter, between admiration for Western models and a desire to mould himself thereon, and an inherent Indian tradition that runs in his veins and will not be denied." - Summary by LynneT and from the Preface.

God, who at sundry times, and in divers manners, spake in time past unto the fathers by the prophets, hath in these last days spoken unto us by his Son, whom he hath appointed heir of all things, by whom also he made the worlds. Hebrews 1:1-2 - Summary from the text

15Pirates of Shan: A Rick Brant Science-Adventure Story

By Harold L. Goodwin

"The Pirates of Shan: A Rick Brant Science-Adventure Story" tells of three young boys solving the mystery of the disappearance of scientists from the Spindrift Scientific Foundation. Resourcefulness and bravery will help them unravel the secrets around not only the missing scientists but the larter threat as well. - Summary by Cyndajm

16Golden Skull, A Rick Brant Science Adventure Story

By Harold L. Goodwin

Rick Brant and his friends have another adventure in the Philippines. Together Rick, Scotty Chahda and Dr Briotti work to solve a mystery in the backdrop of Filipino culture and history. - Summary by Cyndajm

17Electronic Mind Reader: A Rick Brant Science-Adventure Story

By Harold L. Goodwin

Rick, Scotty and Barby concoct a plan to use hidden technology in a quiz show. In the background, the Coast Guard contacts Spindrift Scientists with a potentially dangerous set of circumstances affecting the island. There's plenty of mystery and intrigue to go around! (Summary by Cyndajm)

18Scarlet Lake Mystery: A Rick Brant Science-Adventure Story

By Harold L. Goodwin

Rick, Scotty and Barby have a new challenge related to their work at a secret rocket base. Science and ingenuity will be the skills that solve the mystery and stop the sabotage! - Summary by Cyndajm