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Hidden Target by Helen Macinnes
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1The Hidden Target
By MacInnes, Helen, 1907-1985
“The Hidden Target” Metadata:
- Title: The Hidden Target
- Author: MacInnes, Helen, 1907-1985
- Language: English
Edition Identifiers:
- Internet Archive ID: hiddentargethele00maci
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The book is available for download in "texts" format, the size of the file-s is: 515.32 Mbs, the file-s for this book were downloaded 292 times, the file-s went public at Wed Apr 21 2010.
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2Optimal Random Search For A Single Hidden Target
By Joseph Snider
A single target is hidden at a location chosen from a predetermined probability distribution. Then, a searcher must find a second probability distribution from which random search points are sampled such that the target is found in the minimum number of trials. Here it will be shown that if the searcher must get very close to the target to find it, then the best search distribution is proportional to the square root of the target distribution. For a Gaussian target distribution, the optimum search distribution is approximately a Gaussian with a standard deviation that varies inversely with how close the searcher must be to the target to find it. For a network, where the searcher randomly samples nodes and looks for the fixed target along edges, the optimum is to either sample a node with probability proportional to the square root of the out degree plus one or not at all.
“Optimal Random Search For A Single Hidden Target” Metadata:
- Title: ➤ Optimal Random Search For A Single Hidden Target
- Author: Joseph Snider
- Language: English
Edition Identifiers:
- Internet Archive ID: arxiv-1007.3774
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The book is available for download in "texts" format, the size of the file-s is: 7.22 Mbs, the file-s for this book were downloaded 89 times, the file-s went public at Sat Jul 20 2013.
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3Quickest Detection Of A Hidden Target And Extremal Surfaces
By Goran Peskir
Let $Z=(Z_t)_{t\ge0}$ be a regular diffusion process started at $0$, let $\ell$ be an independent random variable with a strictly increasing and continuous distribution function $F$, and let $\tau_{\ell}=\inf\{t\ge0\vert Z_t=\ell\}$ be the first entry time of $Z$ at the level $\ell$. We show that the quickest detection problem \[\inf_{\tau}\bigl[\mathsf{P}(\tau 0$. Solving the latter problem we find that the following stopping time is optimal: \[\tau_*=\inf \bigl\{t\ge0\vert f_*(I_t,S_t)\le X_t\le g_*(I_t,S_t)\bigr\},\] where the surfaces $f_*$ and $g_*$ can be characterised as extremal solutions to a couple of first-order nonlinear PDEs expressed in terms of the infinitesimal characteristics of $X$ and $c$. This is done by extending the arguments associated with the maximality principle [Ann. Probab. 26 (1998) 1614-1640] to the three-dimensional setting of the present problem and disclosing the general structure of the solution that is valid in all particular cases. The key arguments developed in the proof should be applicable in similar multi-dimensional settings.
“Quickest Detection Of A Hidden Target And Extremal Surfaces” Metadata:
- Title: ➤ Quickest Detection Of A Hidden Target And Extremal Surfaces
- Author: Goran Peskir
“Quickest Detection Of A Hidden Target And Extremal Surfaces” Subjects and Themes:
- Subjects: Probability - Mathematics
Edition Identifiers:
- Internet Archive ID: arxiv-1409.1745
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The book is available for download in "texts" format, the size of the file-s is: 0.45 Mbs, the file-s for this book were downloaded 22 times, the file-s went public at Sat Jun 30 2018.
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4BREAKING: IDF Destroys CRITICAL Hezbollah Target; Exposes HIDDEN Hamas Iran Connection | TBN Israel
By TBN Israel
TBN Israel's Yair Pinto reports on the Israel-Hamas War. Pinto reports of an IDF airstrike on a controversial water pumping station inside Lebanon; a crucial piece of infrastructure which supplies water to neighboring communities and effectively turns off the water to Hezbollah. Israeli forces have also recovered Hamas documents detailing its financial support from Iran, totaling $154 million. In Judea and Samaria, Israeli security forces continue to arrest wanted terrorism suspects.
“BREAKING: IDF Destroys CRITICAL Hezbollah Target; Exposes HIDDEN Hamas Iran Connection | TBN Israel” Metadata:
- Title: ➤ BREAKING: IDF Destroys CRITICAL Hezbollah Target; Exposes HIDDEN Hamas Iran Connection | TBN Israel
- Author: TBN Israel
- Language: english-handwritten
“BREAKING: IDF Destroys CRITICAL Hezbollah Target; Exposes HIDDEN Hamas Iran Connection | TBN Israel” Subjects and Themes:
- Subjects: ➤ Hamas - Israel - Middle East - Palestinians - Gaza - Terrorist - Jihad - Iran
Edition Identifiers:
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The book is available for download in "movies" format, the size of the file-s is: 73.03 Mbs, the file-s for this book were downloaded 23 times, the file-s went public at Sat Feb 24 2024.
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5Theoretical Framework To Analyze Searches For Hidden Light Gauge Bosons In Electron Scattering Fixed Target Experiments
By T. Beranek, H. Merkel and M. Vanderhaeghen
Motivated by anomalies in cosmic ray observations and by attempts to solve questions of the Standad Model of particle physics like the (g-2)_mu discrepancy, U(1) extensions of the Standard Model have been proposed in recent years. Such U(1) extensions allow for the interaction of Dark Matter by exchange of a photon-like massive force carrier \gamma' not included in the Standard Model. In order to search for \gamma' bosons various experimental programs have been started. One approach is the dedicated search at fixed-target experiments at modest energies as performed at MAMI or at the Jefferson Lab. In these experiments the process e(A,Z)->e(A,Z)l^+l^- is investigated and a search for a very narrow resonance in the invariant mass distribution of the l^+l^- pair is performed. In this work we analyze this process in terms of signal and background in order to describe existing data obtained by the A1 experiment at MAMI with the aim to give accurate predictions for exclusion limits in the \gamma' parameter space. We present a detailed theoretical analysis of the cross sections entering in the description of such processes.
“Theoretical Framework To Analyze Searches For Hidden Light Gauge Bosons In Electron Scattering Fixed Target Experiments” Metadata:
- Title: ➤ Theoretical Framework To Analyze Searches For Hidden Light Gauge Bosons In Electron Scattering Fixed Target Experiments
- Authors: T. BeranekH. MerkelM. Vanderhaeghen
- Language: English
Edition Identifiers:
- Internet Archive ID: arxiv-1303.2540
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The book is available for download in "texts" format, the size of the file-s is: 10.45 Mbs, the file-s for this book were downloaded 68 times, the file-s went public at Mon Sep 23 2013.
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6DTIC ADA300872: Low-Frequency Active Target Characterization Using Hidden Markov Models And Classifiers.
By Defense Technical Information Center
We investigate various projection spaces and extract key parameters or features from each space to characterize low-frequency active (LFA) target returns in a low-dimensional space. The projection spaces encompass (1) time embedded phase map, (2) segmented matched filter output, (3) various time frequency distribution functions, such as Reduced Interference Distribution, to capture time-varying echo signatures, and (4) principal component inversion for signal cleaning and characterization. We utilize both dynamic and static features and parameterize them with a hybrid classification methodology consisting of hidden Markov models, classifiers, and data fusion. This clue identification and evaluation process is complemented by concurrent work on target physics to enhance our understanding of the target echo formation process. As a function of target aspect, we can observe (1) back scatter dominated by axial n=O modes propagating back and forth along the length of the shell, (2) direct scatter from shell discontinuities, (3) helical or creeping waves from phase matching between the acoustic waves and membrane waves (both shear and compressional), and (4) the "array response" of the shell, with coherent super- position of elemental scattering sites along the shell leading to a peak response near broadside. As a function of target structures (the empty shell and the ribbed/complex shells), we see considerable complexity brought about by multiple reflections of the membrane waves between the rings. We show the merit of fusing parameters estimated from these projection spaces in characterizing LFA target returns using the MIT/NRL scaled model data. Our hybrid classifiers outperform the matched filter-based recognizer by an average of 5 to 25%.
“DTIC ADA300872: Low-Frequency Active Target Characterization Using Hidden Markov Models And Classifiers.” Metadata:
- Title: ➤ DTIC ADA300872: Low-Frequency Active Target Characterization Using Hidden Markov Models And Classifiers.
- Author: ➤ Defense Technical Information Center
- Language: English
“DTIC ADA300872: Low-Frequency Active Target Characterization Using Hidden Markov Models And Classifiers.” Subjects and Themes:
- Subjects: ➤ DTIC Archive - Kil, David H. - LOCKHEED SANDERS INC NASHUA NH - *TARGET CLASSIFICATION - *LOW FREQUENCY - *MARKOV PROCESSES - *TARGET ECHOES - MATHEMATICAL MODELS - OUTPUT - PROPAGATION - METHODOLOGY - PEAK VALUES - DYNAMICS - ACOUSTIC WAVES - PROBABILITY - ARRAYS - SHELLS(STRUCTURAL FORMS) - TARGETS - REDUCTION - TIME - VARIATIONS - TOPOLOGY - PHYSICS - ECHOES - RESPONSE - LENGTH - SIGNALS - INTERFERENCE - CREEP - CLASSIFICATION - SIGNATURES - HYBRID SYSTEMS - INVERSION - DATA FUSION - RINGS - DISCONTINUITIES - STATICS - MATCHED FILTERS - MATCHING - MULTIPURPOSE - WAVES - SEGMENTED - HELIXES.
Edition Identifiers:
- Internet Archive ID: DTIC_ADA300872
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The book is available for download in "texts" format, the size of the file-s is: 40.13 Mbs, the file-s for this book were downloaded 63 times, the file-s went public at Sat Mar 24 2018.
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7Fri 08 Apr: Wicked Games - Truth Hidden - Assets Popping - Prayer Pause - Target Kids - Role2Play - Deal Making
By The Tore Says Show
The info war is spreading into numerous high level struggles. The SAG is back, thanks to Sean. Odd articles are starting to showing up. Those henchmen once paid are now flipping. The public can no longer recognize the truth. It's time to call evil by it's true name. Multi tasking during the demon battle. Doing the right thing means sometimes helping losers. Center yourself and take some prayer time. CAA funding and what they really do. J6 lockups are intimidation. No doubt, their target is the family. Working the system after the dust settles. All MSM is scripted. Those outsourced are also unprotected. So much backup for that one laptop. Revenge is bait. Does whistle blower mean cloud access? From here, it looks like unneeded deal cutting. The Finger Lakes and a zone of evil. The entire fight is about control, of information and of us. It's not like she told us so, it's more like a friendly warning. Learn more about your ad choices. Visit megaphone.fm/adchoices
“Fri 08 Apr: Wicked Games - Truth Hidden - Assets Popping - Prayer Pause - Target Kids - Role2Play - Deal Making” Metadata:
- Title: ➤ Fri 08 Apr: Wicked Games - Truth Hidden - Assets Popping - Prayer Pause - Target Kids - Role2Play - Deal Making
- Author: The Tore Says Show
Edition Identifiers:
- Internet Archive ID: ➤ nnzw0iedn2tnwhxteum9hmxa4savwxbwmujg5kob
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8The Hidden Target
By MacInnes, Helen, 1907-1985
405 pages ; 22 cm
“The Hidden Target” Metadata:
- Title: The Hidden Target
- Author: MacInnes, Helen, 1907-1985
- Language: English
Edition Identifiers:
- Internet Archive ID: hiddentarget0000maci
Downloads Information:
The book is available for download in "texts" format, the size of the file-s is: 1043.77 Mbs, the file-s for this book were downloaded 67 times, the file-s went public at Wed May 05 2021.
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9The Hidden Target
By MacInnes, Helen, 1907-1985
483 pages ; 20 cm
“The Hidden Target” Metadata:
- Title: The Hidden Target
- Author: MacInnes, Helen, 1907-1985
- Language: English
Edition Identifiers:
- Internet Archive ID: hiddentarget0000maci_e7w8
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The book is available for download in "texts" format, the size of the file-s is: 792.50 Mbs, the file-s for this book were downloaded 76 times, the file-s went public at Mon Jun 21 2021.
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10DTIC ADA259210: High Range Resolution Radar Target Identification Using The Prony Model And Hidden Markov Models
By Defense Technical Information Center
Fully polarized Xpatch signatures are transformed to two left circularly polarized signals. These two signals are then filtered by a linear FM pulse compression ('chirp') transfer function, corrupted by AWGN, and filtered by a filter matched to the 'chirp' transfer function. The bandwidth of the 'chirp' radar is about 750 MHz. Range profile feature extraction is performed using the TLS Prony Model parameter estimation technique developed at Ohio State University. Using the Prony Model, each scattering center is described by a polarization ellipse, relative energy, frequency response, and range. This representation of the target is vector quantized using a K-means clustering algorithm. Sequences of vector quantized scattering centers as well as sequences of vector quantized range profiles are used to synthesize target specific Hidden Markov Models (HMM's). The identification decision is made by determining which HMM has the highest probability of generating the unknown sequence. The data consist of synthesized Xpatch signatures of two targets which have been difficult to separate with other RTI algorithms. The RTI algorithm developed for this thesis is clearly able to separate these two targets over a 10 by 10 degree (1 degree granularity) aspect angle window off the nose for SNRs as low as 0 dB. The classification rate is 100 % for SNRs of 5 - 20 dB, 95 % for a SNR of 0 dB and it drops rapidly for SNRs lower than 0 dB.
“DTIC ADA259210: High Range Resolution Radar Target Identification Using The Prony Model And Hidden Markov Models” Metadata:
- Title: ➤ DTIC ADA259210: High Range Resolution Radar Target Identification Using The Prony Model And Hidden Markov Models
- Author: ➤ Defense Technical Information Center
- Language: English
“DTIC ADA259210: High Range Resolution Radar Target Identification Using The Prony Model And Hidden Markov Models” Subjects and Themes:
- Subjects: ➤ DTIC Archive - DeWitt, Mark R - AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING - *HIGH RESOLUTION - *RADAR TARGETS - *RANGE(DISTANCE) - COMPRESSION - ALGORITHMS - FREQUENCY - FUNCTIONS - ANGLES - SCATTERING - POLARIZATION - TRANSFER FUNCTIONS - MODELS - PARAMETERS - PROBABILITY - OHIO - ENERGY - RESOLUTION - RATES - THESES - RADAR - ELLIPSES - ASPECT ANGLE - PULSE COMPRESSION - FREQUENCY RESPONSE - NOSES - BANDWIDTH - TRANSFER - FILTERS - UNIVERSITIES - EXTRACTION - SIGNATURES - CLASSIFICATION - DROPS - SIGNALS - RESPONSE - PULSES - PROFILES - CLUSTERING - IDENTIFICATION - SEQUENCES - TARGETS
Edition Identifiers:
- Internet Archive ID: DTIC_ADA259210
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The book is available for download in "texts" format, the size of the file-s is: 60.70 Mbs, the file-s for this book were downloaded 69 times, the file-s went public at Fri Mar 09 2018.
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11Hidden Target (DE) (2009)
By Gingerbread Studios
Hidden Target (DE)(Gingerbread Studios, City Interactive S.A.)(2009)
“Hidden Target (DE) (2009)” Metadata:
- Title: Hidden Target (DE) (2009)
- Author: Gingerbread Studios
- Language: ger
“Hidden Target (DE) (2009)” Subjects and Themes:
- Subjects: Game - Video Game
Edition Identifiers:
- Internet Archive ID: Hidden_Target-DE-trgf
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The book is available for download in "software" format, the size of the file-s is: 1823.96 Mbs, the file-s for this book were downloaded 8 times, the file-s went public at Wed Feb 26 2025.
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12All The Hidden Ways Facebook Ads Target You
By VICE News
Facebook executives often talk about their mission as “bringing the world closer together.” With more than 2 billion users, it’s true that the platform does connect people. But one thing that Mark Zuckerberg’s two days of congressional testimony highlighted is that simply connecting people is not how Facebook reached a market cap of nearly $500 billion. At its core, Facebook is an advertising company. In 2017, 98 percent of its $40 billion in revenue came from advertising. It’s not your data that Facebook is selling, it’s your attention. Facebook’s ad platform translates your clicks and posts into “user attributes,” and places you in certain categories for advertisers. For example, your activity could suggest an that you recently had a child, that you’re a Bernie Sanders fan, or that you have an “affinity” for certain racial groups. One of the most powerful features is called “Custom Audiences,” which allows an advertiser to target individuals based on offline information such as email address or phone numbers. An advertiser can upload that data to Facebook, which will match them with its user base to find who they belong to. Then there are so-called “dark posts,” a feature Facebook is in the process of changing, which only show up in the news feeds of specific audiences and are completely hidden to everyone else. These tools can be used by anyone who wants to advertise on Facebook, and critics say that’s an open invitation for malicious actors. Watch this video to learn more about how Facebook’s ad targeting works, and why it’s so effective. Subscribe to VICE News here: [URL REMOVED] Check out VICE News for more: [URL REMOVED] Follow VICE News here: Facebook: [URL REMOVED] Twitter: [URL REMOVED] Tumblr: [URL REMOVED] Instagram: [URL REMOVED] More videos from the VICE network: [URL REMOVED]
“All The Hidden Ways Facebook Ads Target You” Metadata:
- Title: ➤ All The Hidden Ways Facebook Ads Target You
- Author: VICE News
Edition Identifiers:
- Internet Archive ID: ➤ AllTheHiddenWaysFacebookAdsTargetYou
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13The Hidden Target
By MacInnes, Helen, 1907-1985
Facebook executives often talk about their mission as “bringing the world closer together.” With more than 2 billion users, it’s true that the platform does connect people. But one thing that Mark Zuckerberg’s two days of congressional testimony highlighted is that simply connecting people is not how Facebook reached a market cap of nearly $500 billion. At its core, Facebook is an advertising company. In 2017, 98 percent of its $40 billion in revenue came from advertising. It’s not your data that Facebook is selling, it’s your attention. Facebook’s ad platform translates your clicks and posts into “user attributes,” and places you in certain categories for advertisers. For example, your activity could suggest an that you recently had a child, that you’re a Bernie Sanders fan, or that you have an “affinity” for certain racial groups. One of the most powerful features is called “Custom Audiences,” which allows an advertiser to target individuals based on offline information such as email address or phone numbers. An advertiser can upload that data to Facebook, which will match them with its user base to find who they belong to. Then there are so-called “dark posts,” a feature Facebook is in the process of changing, which only show up in the news feeds of specific audiences and are completely hidden to everyone else. These tools can be used by anyone who wants to advertise on Facebook, and critics say that’s an open invitation for malicious actors. Watch this video to learn more about how Facebook’s ad targeting works, and why it’s so effective. Subscribe to VICE News here: [URL REMOVED] Check out VICE News for more: [URL REMOVED] Follow VICE News here: Facebook: [URL REMOVED] Twitter: [URL REMOVED] Tumblr: [URL REMOVED] Instagram: [URL REMOVED] More videos from the VICE network: [URL REMOVED]
“The Hidden Target” Metadata:
- Title: The Hidden Target
- Author: MacInnes, Helen, 1907-1985
- Language: English
Edition Identifiers:
- Internet Archive ID: hiddentarget00maci
Downloads Information:
The book is available for download in "texts" format, the size of the file-s is: 512.86 Mbs, the file-s for this book were downloaded 345 times, the file-s went public at Fri Dec 11 2009.
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14Hidden Target (Jonathan Kane: The Protector) PL
By CI Games
Płyta (ISO) z grą Hidden Target (Jonathan Kane: The Protector w anglojęzycznych krajach ) z czasopisma Imperium Gier DVD Wydanie Specjalne nr 1/2009.
“Hidden Target (Jonathan Kane: The Protector) PL” Metadata:
- Title: ➤ Hidden Target (Jonathan Kane: The Protector) PL
- Author: CI Games
“Hidden Target (Jonathan Kane: The Protector) PL” Subjects and Themes:
- Subjects: ➤ Hidden Target - Gingerbread Studios - City Interactive - CI Games - Imperium Gier - Imperium Gier DVD - Imperium Gier DVD Wydanie Specjalne - Jonathan Kane: The Protector - Tri Synergy
Edition Identifiers:
- Internet Archive ID: ht_20221221
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15Hidden Target
Juego de tiros que mezcla primera y tercera persona, también conocido como " Jonathan Kane: The Protector ". Voces en inglés, texto en español. Probado en Windows 10.
“Hidden Target” Metadata:
- Title: Hidden Target
- Language: ➤ Spanish; Castilian - español, castellano
“Hidden Target” Subjects and Themes:
Edition Identifiers:
- Internet Archive ID: hidden-target
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The book is available for download in "software" format, the size of the file-s is: 1854.89 Mbs, the file-s for this book were downloaded 275 times, the file-s went public at Sun Sep 27 2020.
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16New Limits On Light Hidden Sectors From Fixed-Target Experiments
By David E. Morrissey and Andrew Paul Spray
New physics can be light if it is hidden, coupling very weakly to the Standard Model. In this work we investigate the discovery prospects of Abelian hidden sectors in lower-energy fixed-target and high-precision experiments. We focus on a minimal supersymmetric realization consisting of an Abelian vector multiplet, coupled to hypercharge by kinetic mixing, and a pair of chiral Higgs multiplets. This simple theory can give rise to a broad range of experimental signals, including both commonly-studied patterns of hidden vector decay as well as new and distinctive hidden sector cascades. We find limits from the production of hidden states other than the vector itself. In particular, we show that if the hidden Abelian symmetry is higgsed, and the corresponding hidden Higgs boson has visible decays, it severely restricts the ability of the hidden sector to explain the anomalous muon magnetic moment.
“New Limits On Light Hidden Sectors From Fixed-Target Experiments” Metadata:
- Title: ➤ New Limits On Light Hidden Sectors From Fixed-Target Experiments
- Authors: David E. MorrisseyAndrew Paul Spray
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- Internet Archive ID: arxiv-1402.4817
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17The Hidden Target
By Helen MacInnes
New physics can be light if it is hidden, coupling very weakly to the Standard Model. In this work we investigate the discovery prospects of Abelian hidden sectors in lower-energy fixed-target and high-precision experiments. We focus on a minimal supersymmetric realization consisting of an Abelian vector multiplet, coupled to hypercharge by kinetic mixing, and a pair of chiral Higgs multiplets. This simple theory can give rise to a broad range of experimental signals, including both commonly-studied patterns of hidden vector decay as well as new and distinctive hidden sector cascades. We find limits from the production of hidden states other than the vector itself. In particular, we show that if the hidden Abelian symmetry is higgsed, and the corresponding hidden Higgs boson has visible decays, it severely restricts the ability of the hidden sector to explain the anomalous muon magnetic moment.
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- Title: The Hidden Target
- Author: Helen MacInnes
- Language: English
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- Internet Archive ID: hiddentarget0000hele
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18The Hidden Target
By MacInnes, Helen, 1907-1985
New physics can be light if it is hidden, coupling very weakly to the Standard Model. In this work we investigate the discovery prospects of Abelian hidden sectors in lower-energy fixed-target and high-precision experiments. We focus on a minimal supersymmetric realization consisting of an Abelian vector multiplet, coupled to hypercharge by kinetic mixing, and a pair of chiral Higgs multiplets. This simple theory can give rise to a broad range of experimental signals, including both commonly-studied patterns of hidden vector decay as well as new and distinctive hidden sector cascades. We find limits from the production of hidden states other than the vector itself. In particular, we show that if the hidden Abelian symmetry is higgsed, and the corresponding hidden Higgs boson has visible decays, it severely restricts the ability of the hidden sector to explain the anomalous muon magnetic moment.
“The Hidden Target” Metadata:
- Title: The Hidden Target
- Author: MacInnes, Helen, 1907-1985
- Language: English
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19Fitting Hidden Markov Models Of Protein Domains To A Target Species: Application To Plasmodium Falciparum.
By Terrapon, Nicolas, Gascuel, Olivier, Marechal, Eric and Brehelin, Laurent
This article is from BMC Bioinformatics , volume 13 . Abstract Background: Hidden Markov Models (HMMs) are a powerful tool for protein domain identification. The Pfam database notably provides a large collection of HMMs which are widely used for the annotation of proteins in new sequenced organisms. In Pfam, each domain family is represented by a curated multiple sequence alignment from which a profile HMM is built. In spite of their high specificity, HMMs may lack sensitivity when searching for domains in divergent organisms. This is particularly the case for species with a biased amino-acid composition, such as P. falciparum, the main causal agent of human malaria. In this context, fitting HMMs to the specificities of the target proteome can help identify additional domains. Results: Using P. falciparum as an example, we compare approaches that have been proposed for this problem, and present two alternative methods. Because previous attempts strongly rely on known domain occurrences in the target species or its close relatives, they mainly improve the detection of domains which belong to already identified families. Our methods learn global correction rules that adjust amino-acid distributions associated with the match states of HMMs. These rules are applied to all match states of the whole HMM library, thus enabling the detection of domains from previously absent families. Additionally, we propose a procedure to estimate the proportion of false positives among the newly discovered domains. Starting with the Pfam standard library, we build several new libraries with the different HMM-fitting approaches. These libraries are first used to detect new domain occurrences with low E-values. Second, by applying the Co-Occurrence Domain Discovery (CODD) procedure we have recently proposed, the libraries are further used to identify likely occurrences among potential domains with higher E-values. Conclusion: We show that the new approaches allow identification of several domain families previously absent in the P. falciparum proteome and the Apicomplexa phylum, and identify many domains that are not detected by previous approaches. In terms of the number of new discovered domains, the new approaches outperform the previous ones when no close species are available or when they are used to identify likely occurrences among potential domains with high E-values. All predictions on P. falciparum have been integrated into a dedicated website which pools all known/new annotations of protein domains and functions for this organism. A software implementing the two proposed approaches is available at the same address: http://www.lirmm.fr/∼terrapon/HMMfit/
“Fitting Hidden Markov Models Of Protein Domains To A Target Species: Application To Plasmodium Falciparum.” Metadata:
- Title: ➤ Fitting Hidden Markov Models Of Protein Domains To A Target Species: Application To Plasmodium Falciparum.
- Authors: Terrapon, NicolasGascuel, OlivierMarechal, EricBrehelin, Laurent
- Language: English
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- Internet Archive ID: pubmed-PMC3434054
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20The Hidden Target
This article is from BMC Bioinformatics , volume 13 . Abstract Background: Hidden Markov Models (HMMs) are a powerful tool for protein domain identification. The Pfam database notably provides a large collection of HMMs which are widely used for the annotation of proteins in new sequenced organisms. In Pfam, each domain family is represented by a curated multiple sequence alignment from which a profile HMM is built. In spite of their high specificity, HMMs may lack sensitivity when searching for domains in divergent organisms. This is particularly the case for species with a biased amino-acid composition, such as P. falciparum, the main causal agent of human malaria. In this context, fitting HMMs to the specificities of the target proteome can help identify additional domains. Results: Using P. falciparum as an example, we compare approaches that have been proposed for this problem, and present two alternative methods. Because previous attempts strongly rely on known domain occurrences in the target species or its close relatives, they mainly improve the detection of domains which belong to already identified families. Our methods learn global correction rules that adjust amino-acid distributions associated with the match states of HMMs. These rules are applied to all match states of the whole HMM library, thus enabling the detection of domains from previously absent families. Additionally, we propose a procedure to estimate the proportion of false positives among the newly discovered domains. Starting with the Pfam standard library, we build several new libraries with the different HMM-fitting approaches. These libraries are first used to detect new domain occurrences with low E-values. Second, by applying the Co-Occurrence Domain Discovery (CODD) procedure we have recently proposed, the libraries are further used to identify likely occurrences among potential domains with higher E-values. Conclusion: We show that the new approaches allow identification of several domain families previously absent in the P. falciparum proteome and the Apicomplexa phylum, and identify many domains that are not detected by previous approaches. In terms of the number of new discovered domains, the new approaches outperform the previous ones when no close species are available or when they are used to identify likely occurrences among potential domains with high E-values. All predictions on P. falciparum have been integrated into a dedicated website which pools all known/new annotations of protein domains and functions for this organism. A software implementing the two proposed approaches is available at the same address: http://www.lirmm.fr/∼terrapon/HMMfit/
“The Hidden Target” Metadata:
- Title: The Hidden Target
- Language: English
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- Internet Archive ID: hiddentarget0000unse
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Source: The Open Library
The Open Library Search Results
Available books for downloads and borrow from The Open Library
1The hidden target
By Helen MacInnes

“The hidden target” Metadata:
- Title: The hidden target
- Author: Helen MacInnes
- Language: English
- Number of Pages: Median: 405
- Publisher: ➤ Charnwood - Chivers Audio Books - G.K. Hall - Harcourt Brace Jovanovich - Titan Books Limited - Fawcett Crest - Collins - Fontana - Titan Books - HarperCollins Publishers - Fawcett - Harcourt
- Publish Date: ➤ 1980 - 1981 - 1982 - 1986 - 1987 - 1996 - 2013
- Publish Location: ➤ Boston, Mass - New York - Leicester - London - (London)
“The hidden target” Subjects and Themes:
- Subjects: ➤ Large type books - Fiction, general - Fiction, espionage - Fiction, thrillers, general - Fiction, thrillers, espionage - Terrorists - Fiction
Edition Identifiers:
- The Open Library ID: ➤ OL49656624M - OL49349243M - OL43664217M - OL43353771M - OL43453140M - OL43604000M - OL29165262M - OL34514498M - OL7567926M - OL4254856M - OL18169029M - OL4095093M - OL17484123M - OL14422508M - OL21148318M - OL9431646M - OL9212791M - OL7565709M - OL24209459M - OL7258075M - OL14876391M
- Online Computer Library Center (OCLC) ID: 7840499 - 36002277 - 7281897 - 6486641
- Library of Congress Control Number (LCCN): 2015301776 - 80007953 - 81000173
- All ISBNs: ➤ 9780449207093 - 9780449244432 - 1306917433 - 0002222825 - 0449244431 - 9780449200599 - 0449200590 - 9781781163399 - 9780002222822 - 9780745167077 - 0006172202 - 9781306917438 - 9780006163299 - 9780006172208 - 0816131538 - 0745167071 - 9780708980224 - 0449207099 - 0708980228 - 9780816131532 - 1781163391 - 9780151401987 - 0151401985 - 0006163297
Author's Alternative Names:
"Helen Clark MacInnes", "H MacInnes", "Helen. Macinnes", "MacInnes Helen", "Helen Macinnes", "Macinnes Helen", "Hellen MacInnes", "helen macinnes", "Helen MACINNES", "Helen MacINNES" and "HELEN MACINNES",Access and General Info:
- First Year Published: 1980
- Is Full Text Available: Yes
- Is The Book Public: No
- Access Status: Borrowable
Online Access
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2Helen Macinnes: Three Bestselling Novels of Terror & Espionage : Agent in Place : The Hidden Target
Cloak of Darkness
By Helen MacInnes

“Helen Macinnes: Three Bestselling Novels of Terror & Espionage : Agent in Place : The Hidden Target” Metadata:
- Title: ➤ Helen Macinnes: Three Bestselling Novels of Terror & Espionage : Agent in Place : The Hidden Target
- Author: Helen MacInnes
- Language: English
- Publisher: BBS Publishing Corporation
- Publish Date: 1993
“Helen Macinnes: Three Bestselling Novels of Terror & Espionage : Agent in Place : The Hidden Target” Subjects and Themes:
- Subjects: Fiction, thrillers, general - Fiction, suspense
Edition Identifiers:
- The Open Library ID: OL9684456M
- All ISBNs: 0883658143 - 9780883658147
Author's Alternative Names:
"MacInnes Helen", "Helen Macinnes", "Helen MacINNES", "Hellen MacInnes", "Helen Clark MacInnes", "helen macinnes", "Helen. Macinnes", "HELEN MACINNES", "Macinnes Helen", "H MacInnes" and "Helen MACINNES",Access and General Info:
- First Year Published: 1993
- Is Full Text Available: Yes
- Is The Book Public: No
- Access Status: Borrowable
Online Access
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