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The increasing amount of clinical evidence derived from Korean real world data (RWD) and the interest in using it in regulatory decision-making have prompted the need to evaluate how the findings of Korean RWD mimicked those of randomized controlled trials (RCTs) and real world evidence (RWE). Hence, verifying the reliability of Korean RWD through trial emulations with previously validated methods is a prerequisite for implementing RWE in regulatory decision-making. If the results of trial emulations using Korean RWD were in line with corresponding RCTs, and also with prior emulation studies, we would then have greater confidence in evidence generated from Korean RWD and its use in decision-making. Therefore, we aimed to emulate the landmark trials of non-vitamin K antagonist oral anticoagulants to investigate their reproducibility when implemented in Korean RWD sources.