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Effects Of Scn1a And Scn2a Polymorphisms On Responsiveness To Valproic Acid Monotherapy In Epileptic Children%3a A Protocol For Systematic Review And Meta Analysis by Lijiao Chen

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1Effects Of SCN1A And SCN2A Polymorphisms On Responsiveness To Valproic Acid Monotherapy In Epileptic Children: A Protocol For Systematic Review And Meta-analysis

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The gene mutation of coding sodium channel is one of the most important mechanisms in the pathogenesis of epilepsy. There exists a large inter-individual variation in the efficacy of valproic acid (VPA) against epilepsy. What are the genetic polymorphism influences of sodium channels on VPA response is still under discussion. In this study, a meta-analysis was used to further explore the effects of SCN1A and SCN2A gene polymorphism on VPA response in children with epilepsy.

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  • Title: ➤  Effects Of SCN1A And SCN2A Polymorphisms On Responsiveness To Valproic Acid Monotherapy In Epileptic Children: A Protocol For Systematic Review And Meta-analysis
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