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Allogeneic (donor) blood transfusions can save lives when treating blood loss due to trauma, surgery or disease. But transfusions carry risks. Current practices are often sub-optimal, and many patients are inappropriately transfused. This research goal is to improve transfusion practice by creating and testing an evidenced based Patient Blood Management (PBM) curriculum. To identify best practices, investigators have analyzed over 300,000 peer reviewed manuscripts and encapsulated these findings into a computerized, online knowledge repository of documented PBM best practices. The team concurrently developed a state of the art, multi-modality PBM curriculum that translates the evidenced based findings into clinical best practice training. The budget for this five year study was reduced to three years midway thru its execution. Consequently, the research was limited to: 1) Configuring, building and populating the evidenced based PBM knowledge repository; and 2) Developing the multi-modality training curriculum. Testing of the tools will have to be pursued in future research. The study, though lacking the budgeted funds necessary to fully realize its original objectives, has produced three important deliverables: 1) A one of a kind, comprehensive PBM best practice knowledgebase; 2) An associated PBM multi-modality curriculum to translate evidence based best practices to clinical standards of care; and,3) produced advanced simulation PBM training tools which can measurably enhance PBM best practice skill acquisition.