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Traditionally, medical surveillance of liver disease generally involves a battery of tests. This research used multivariate analysis techniques to reduce the number of measures required to identify liver dysfunction and found using a Transferase Index (a combination of three tests; ALT, AST, and GGT) provided the most satisfying assessment, but the single best indicator, ALT, may be sufficient. Transferase Index and ALT criterion were both applied to SPC control charts. Through the use of statistical process control (SPC), this research identified work zones possessing signs of adverse effects to an individual's liver as a possible result of their work environment and demonstrated SPC as an excellent way to conduct medical surveillance. Industry has embraced SPC, and control charts, this research extended their scope and demonstrated their effective use in medical surveillance of the liver. This research showed they provide easy, efficient ways to monitor work environments.