Downloads & Free Reading Options - Results

The objective of the project, to date, has been to focus on biological issues believed to be important in converting toxin dosage to pre- cancerous and cancerous cells, and to translate these into appropriate quantitative mathematical terms. In particular, models that stem from the clonal expansion mechanisms identified by Moolgavkar and co-workers, cf, sample references (1979), (1983), have been studied, generalized (to account for possible variability or susceptibility between individual fish), and adapted for fitting to actual data. It appears to be widely believed that pre-cancerous conditions in an organ (the liver) occur as a result of cell clonal expansion, followed by a promotion (to tumor) event. Specific models for this has been proposed and developed by Moolgavkar and co-workers. More recent work is by C. J. Portier and co-workers.