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Critical Population And Error Threshold On The Sharp Peak Landscape For A Moran Model by Raphaël Cerf
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1Critical Population And Error Threshold On The Sharp Peak Landscape For A Moran Model
By Raphaël Cerf
The goal of this work is to propose a finite population counterpart to Eigen's model, which incorporates stochastic effects. We consider a Moran model describing the evolution of a population of size $m$ of chromosomes of length $\ell$ over an alphabet of cardinality $\kappa$. The mutation probability per locus is $q$. We deal only with the sharp peak landscape: the replication rate is $\sigma>1$ for the master sequence and 1 for the other sequences. We study the equilibrium distribution of the process in the regime where $\ell, m\to +\infty$, $q\to 0$, $\ell q \to a$, $m/\ell\to\alpha$. We obtain an equation $\alpha\phi(a)=\ln\kappa$ in the parameter space $(a,\alpha)$ separating the regime where the equilibrium population is totally random from the regime where a quasispecies is formed. We observe the existence of a critical population size necessary for a quasispecies to emerge and we recover the finite population counterpart of the error threshold. These results are supported by computer simulations.
“Critical Population And Error Threshold On The Sharp Peak Landscape For A Moran Model” Metadata:
- Title: ➤ Critical Population And Error Threshold On The Sharp Peak Landscape For A Moran Model
- Author: Raphaël Cerf
- Language: English
Edition Identifiers:
- Internet Archive ID: arxiv-1205.3435
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The book is available for download in "texts" format, the size of the file-s is: 30.04 Mbs, the file-s for this book were downloaded 57 times, the file-s went public at Fri Sep 20 2013.
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