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In this paper, we present a novel Lagrangian formulation of the equations of motion for point vortices on the unit 2-sphere. We show first that no linear Lagrangian formulation exists directly on the 2-sphere but that a Lagrangian may be constructed by pulling back the dynamics to the 3-sphere by means of the Hopf fibration. We then use the isomorphism of the 3-sphere with the Lie group SU(2) to derive a variational Lie group integrator for point vortices which is symplectic, second-order, and preserves the unit-length constraint. At the end of the paper, we compare our integrator with classical fourth-order Runge--Kutta, the second-order midpoint method, and a standard Lie group Munthe-Kaas method.

We explore the influence of the deformation on the nuclear matrix elements of the neutrinoless double beta decay (NME), concluding that the difference in deformation -or more generally in the amount of quadrupole correlations- between parent and grand daughter nuclei quenches strongly the decay. We correlate these differences with the seniority structure of the nuclear wave functions. In this context, we examine the present discrepancies between the NME's obtained in the framework of the Interacting Shell Model and the Quasiparticle RPA. We surmise that part of the discrepancy can be due to the limitations of the spherical QRPA in treating nuclei which have strong quadrupole correlations. We surmise that the NME's in a basis of generalized seniority are approximately model independent, i. e. they are "universal".

Stealth knowledge is used to make the object less observable and is defined in terms of absorption of electromagnetic waves that is an important research area used in defence research. Radar cross section is the proportion of the objectives capacity to reflect radar signals toward the radar beneficiary. Some techniques such as shaping, radar absorbing material RAM , passive cancellation and active cancellation have been used for RCS reduction purposes. For a long time, radar absorbing material RAM has been actively pursued. For RAM weight, design, thickness, mechanical strength and absorptivity are key factors and therefore in the development of RAM, there is a trade off between weight and thickness of absorber material. Along with this, an alternative to RAM is RAS and metamaterial are one of the possible options. The metamaterial is lightweight and easy to use. The Stealth property of metamaterial is based on material property i.e., permittivity and permeability of material varying from small positive to large negative values at a particular frequency. In this paper, we hada novel study of metamaterial and its various aspects. Manish Verma | SM Abbas "The Novel Study of Metamaterial and Its Aspects" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43731.pdf Paper URL: https://www.ijtsrd.com/physics/engineering-physics/43731/the-novel-study-of-metamaterial-and-its-aspects/manish-verma

We investigate the electronic structure of Sr$_2$FeMoO$_6$ combining photoemission spectroscopy with a wide range of photon energies and electronic structure calculations based on first-principle as well as model Hamiltonian approaches to reveal several interesting aspects. We find evidence for unusually strong Coulomb correlation effects both in the Fe 3$d$ and O 2$p$ states, with an enhanced manifestation in the majority spin channel. Additionally, O 2$p$ states exhibit a spin-splitting of nonmagnetic origin, which nevertheless is likely to have subtle influence on the stability of novel ferromagnetism of this compound.

We investigate the electronic structure of Sr$_2$FeMoO$_6$ combining photoemission spectroscopy with a wide range of photon energies and electronic structure calculations based on first-principle as well as model Hamiltonian approaches to reveal several interesting aspects. We find evidence for unusually strong Coulomb correlation effects both in the Fe 3$d$ and O 2$p$ states, with an enhanced manifestation in the majority spin channel. Additionally, O 2$p$ states exhibit a spin-splitting of nonmagnetic origin, which nevertheless is likely to have subtle influence on the stability of novel ferromagnetism of this compound.

We investigate the electronic structure of Sr$_2$FeMoO$_6$ combining photoemission spectroscopy with a wide range of photon energies and electronic structure calculations based on first-principle as well as model Hamiltonian approaches to reveal several interesting aspects. We find evidence for unusually strong Coulomb correlation effects both in the Fe 3$d$ and O 2$p$ states, with an enhanced manifestation in the majority spin channel. Additionally, O 2$p$ states exhibit a spin-splitting of nonmagnetic origin, which nevertheless is likely to have subtle influence on the stability of novel ferromagnetism of this compound.

We investigate the electronic structure of Sr$_2$FeMoO$_6$ combining photoemission spectroscopy with a wide range of photon energies and electronic structure calculations based on first-principle as well as model Hamiltonian approaches to reveal several interesting aspects. We find evidence for unusually strong Coulomb correlation effects both in the Fe 3$d$ and O 2$p$ states, with an enhanced manifestation in the majority spin channel. Additionally, O 2$p$ states exhibit a spin-splitting of nonmagnetic origin, which nevertheless is likely to have subtle influence on the stability of novel ferromagnetism of this compound.

We investigate the electronic structure of Sr$_2$FeMoO$_6$ combining photoemission spectroscopy with a wide range of photon energies and electronic structure calculations based on first-principle as well as model Hamiltonian approaches to reveal several interesting aspects. We find evidence for unusually strong Coulomb correlation effects both in the Fe 3$d$ and O 2$p$ states, with an enhanced manifestation in the majority spin channel. Additionally, O 2$p$ states exhibit a spin-splitting of nonmagnetic origin, which nevertheless is likely to have subtle influence on the stability of novel ferromagnetism of this compound.

We investigate the electronic structure of Sr$_2$FeMoO$_6$ combining photoemission spectroscopy with a wide range of photon energies and electronic structure calculations based on first-principle as well as model Hamiltonian approaches to reveal several interesting aspects. We find evidence for unusually strong Coulomb correlation effects both in the Fe 3$d$ and O 2$p$ states, with an enhanced manifestation in the majority spin channel. Additionally, O 2$p$ states exhibit a spin-splitting of nonmagnetic origin, which nevertheless is likely to have subtle influence on the stability of novel ferromagnetism of this compound.

This article is from Frontiers in Microbiology , volume 5 . Abstract Mycoplasma pneumoniae (Mp) is a leading cause of community acquired pneumonia. Knowledge regarding Mp pneumonia obtained from animal models or human subjects has been discussed in many different reports. Accumulated expertise concerning this critical issue has been hard to apply clinically, and potential problems may remain undiscovered. Therefore, our multidisciplinary team extensively reviewed the literature regarding Mp pneumonia, and compared findings from animal models with those from human subjects. In human beings, the characteristic pathological features of Mp pneumonia have been reported as alveolar infiltration with neutrophils and lymphocytes and lymphocyte/plasma cell infiltrates in the peri-bronchovascular area. Herein, we demonstrated the novel aspects of Mp pneumonia that the severity of the Mp pneumonia seemed to depend on the host innate immunity to the Mp, which might be accelerated by antecedent Mp exposure (re-exposure or latent respiratory infection) through up-regulation of Toll-like receptor 2 expression on bronchial epithelial cells and alveolar macrophages. The macrolides therapy might be beneficial for the patients with macrolide-resistant Mp pneumonia via not bacteriological but immunomodulative effects. This exhaustive review focuses on pathogenesis and extends to some therapeutic implications such as clarithromycin, and discusses the various diverse aspects of Mp pneumonia. It is our hope that this might lead to new insights into this common respiratory disease.

This article is from Frontiers in Microbiology , volume 5 . Abstract Mycoplasma pneumoniae (Mp) is a leading cause of community acquired pneumonia. Knowledge regarding Mp pneumonia obtained from animal models or human subjects has been discussed in many different reports. Accumulated expertise concerning this critical issue has been hard to apply clinically, and potential problems may remain undiscovered. Therefore, our multidisciplinary team extensively reviewed the literature regarding Mp pneumonia, and compared findings from animal models with those from human subjects. In human beings, the characteristic pathological features of Mp pneumonia have been reported as alveolar infiltration with neutrophils and lymphocytes and lymphocyte/plasma cell infiltrates in the peri-bronchovascular area. Herein, we demonstrated the novel aspects of Mp pneumonia that the severity of the Mp pneumonia seemed to depend on the host innate immunity to the Mp, which might be accelerated by antecedent Mp exposure (re-exposure or latent respiratory infection) through up-regulation of Toll-like receptor 2 expression on bronchial epithelial cells and alveolar macrophages. The macrolides therapy might be beneficial for the patients with macrolide-resistant Mp pneumonia via not bacteriological but immunomodulative effects. This exhaustive review focuses on pathogenesis and extends to some therapeutic implications such as clarithromycin, and discusses the various diverse aspects of Mp pneumonia. It is our hope that this might lead to new insights into this common respiratory disease.

This article is from Frontiers in Microbiology , volume 5 . Abstract Mycoplasma pneumoniae (Mp) is a leading cause of community acquired pneumonia. Knowledge regarding Mp pneumonia obtained from animal models or human subjects has been discussed in many different reports. Accumulated expertise concerning this critical issue has been hard to apply clinically, and potential problems may remain undiscovered. Therefore, our multidisciplinary team extensively reviewed the literature regarding Mp pneumonia, and compared findings from animal models with those from human subjects. In human beings, the characteristic pathological features of Mp pneumonia have been reported as alveolar infiltration with neutrophils and lymphocytes and lymphocyte/plasma cell infiltrates in the peri-bronchovascular area. Herein, we demonstrated the novel aspects of Mp pneumonia that the severity of the Mp pneumonia seemed to depend on the host innate immunity to the Mp, which might be accelerated by antecedent Mp exposure (re-exposure or latent respiratory infection) through up-regulation of Toll-like receptor 2 expression on bronchial epithelial cells and alveolar macrophages. The macrolides therapy might be beneficial for the patients with macrolide-resistant Mp pneumonia via not bacteriological but immunomodulative effects. This exhaustive review focuses on pathogenesis and extends to some therapeutic implications such as clarithromycin, and discusses the various diverse aspects of Mp pneumonia. It is our hope that this might lead to new insights into this common respiratory disease.

This article is from Frontiers in Microbiology , volume 5 . Abstract Mycoplasma pneumoniae (Mp) is a leading cause of community acquired pneumonia. Knowledge regarding Mp pneumonia obtained from animal models or human subjects has been discussed in many different reports. Accumulated expertise concerning this critical issue has been hard to apply clinically, and potential problems may remain undiscovered. Therefore, our multidisciplinary team extensively reviewed the literature regarding Mp pneumonia, and compared findings from animal models with those from human subjects. In human beings, the characteristic pathological features of Mp pneumonia have been reported as alveolar infiltration with neutrophils and lymphocytes and lymphocyte/plasma cell infiltrates in the peri-bronchovascular area. Herein, we demonstrated the novel aspects of Mp pneumonia that the severity of the Mp pneumonia seemed to depend on the host innate immunity to the Mp, which might be accelerated by antecedent Mp exposure (re-exposure or latent respiratory infection) through up-regulation of Toll-like receptor 2 expression on bronchial epithelial cells and alveolar macrophages. The macrolides therapy might be beneficial for the patients with macrolide-resistant Mp pneumonia via not bacteriological but immunomodulative effects. This exhaustive review focuses on pathogenesis and extends to some therapeutic implications such as clarithromycin, and discusses the various diverse aspects of Mp pneumonia. It is our hope that this might lead to new insights into this common respiratory disease.

This article is from Toxins , volume 6 . Abstract Ochratoxin A (OTA) is a mycotoxin produced by different Aspergillus and Penicillium species. Since its mechanism of action is not fully understood yet, it is important to gain further insight into different interactions of OTA at the molecular level. OTA is found worldwide in many foods and drinks. Moreover, it can also be detected in human and animal tissues and body fluids, as well. Therefore, the development of highly sensitive quantitative methods for the determination of OTA is of utmost importance. OTA most likely forms complexes with divalent cations, both in cells and body fluids. In the present study, the OTA-zinc interaction was investigated and compared to OTA-magnesium complex formation using fluorescence spectroscopy and molecular modeling. Our results show that zinc(II) ion forms a two-fold higher stable complex with OTA than magnesium(II) ion. In addition, based on the enhanced fluorescence emission of OTA in its magnesium-bound form, a novel RP-HPLC-fluorescence detector (FLD) method was also established. Our results highlight that the application of magnesium chloride in alkaline eluents results in an approximately two-fold increase in sensitivity using the HPLC-FLD technique.

This article is from Toxins , volume 6 . Abstract Ochratoxin A (OTA) is a mycotoxin produced by different Aspergillus and Penicillium species. Since its mechanism of action is not fully understood yet, it is important to gain further insight into different interactions of OTA at the molecular level. OTA is found worldwide in many foods and drinks. Moreover, it can also be detected in human and animal tissues and body fluids, as well. Therefore, the development of highly sensitive quantitative methods for the determination of OTA is of utmost importance. OTA most likely forms complexes with divalent cations, both in cells and body fluids. In the present study, the OTA-zinc interaction was investigated and compared to OTA-magnesium complex formation using fluorescence spectroscopy and molecular modeling. Our results show that zinc(II) ion forms a two-fold higher stable complex with OTA than magnesium(II) ion. In addition, based on the enhanced fluorescence emission of OTA in its magnesium-bound form, a novel RP-HPLC-fluorescence detector (FLD) method was also established. Our results highlight that the application of magnesium chloride in alkaline eluents results in an approximately two-fold increase in sensitivity using the HPLC-FLD technique.

This article is from Toxins , volume 6 . Abstract Ochratoxin A (OTA) is a mycotoxin produced by different Aspergillus and Penicillium species. Since its mechanism of action is not fully understood yet, it is important to gain further insight into different interactions of OTA at the molecular level. OTA is found worldwide in many foods and drinks. Moreover, it can also be detected in human and animal tissues and body fluids, as well. Therefore, the development of highly sensitive quantitative methods for the determination of OTA is of utmost importance. OTA most likely forms complexes with divalent cations, both in cells and body fluids. In the present study, the OTA-zinc interaction was investigated and compared to OTA-magnesium complex formation using fluorescence spectroscopy and molecular modeling. Our results show that zinc(II) ion forms a two-fold higher stable complex with OTA than magnesium(II) ion. In addition, based on the enhanced fluorescence emission of OTA in its magnesium-bound form, a novel RP-HPLC-fluorescence detector (FLD) method was also established. Our results highlight that the application of magnesium chloride in alkaline eluents results in an approximately two-fold increase in sensitivity using the HPLC-FLD technique.

This article is from Toxins , volume 6 . Abstract Ochratoxin A (OTA) is a mycotoxin produced by different Aspergillus and Penicillium species. Since its mechanism of action is not fully understood yet, it is important to gain further insight into different interactions of OTA at the molecular level. OTA is found worldwide in many foods and drinks. Moreover, it can also be detected in human and animal tissues and body fluids, as well. Therefore, the development of highly sensitive quantitative methods for the determination of OTA is of utmost importance. OTA most likely forms complexes with divalent cations, both in cells and body fluids. In the present study, the OTA-zinc interaction was investigated and compared to OTA-magnesium complex formation using fluorescence spectroscopy and molecular modeling. Our results show that zinc(II) ion forms a two-fold higher stable complex with OTA than magnesium(II) ion. In addition, based on the enhanced fluorescence emission of OTA in its magnesium-bound form, a novel RP-HPLC-fluorescence detector (FLD) method was also established. Our results highlight that the application of magnesium chloride in alkaline eluents results in an approximately two-fold increase in sensitivity using the HPLC-FLD technique.

                Attribution-Noncommercial-No Derivative Works 3.0.                        .....JEWEL IN THE LOTUS.......     Like the lotus that grows in water whose leaves and petals remain dry, the yogi derives nourishment from the material world but remains undefiled and untouched by its seductions. In this way, one who wishes to lead a spiritual life can simultaneously perform the role of a responsible member of modern society; neither necessarily compromises the other. With care, practice and knowledge one can reap the benefits of both worlds – to be spiritual you do not have to run away from the world. This book examines the philosophy, spiritual teachings, metaphysics and cultural practices of Hinduism- known collectively as the Sanatana Dharma- and attempts to give one a grasp of its true essence.   *************************************************                            .... SHUNYA A NOVEL ....   "......He was awakened by an unfamiliar growling sound that seemed to come from above the roof. He saw Shunya sitting on his mat and looking up. The growling grew louder and Thambi’s hair stood on end as he saw a round, cannonball-sized blob of brilliant white light coming through the roof. It descended to the ground in front of where Shunya was seated. Then the blob elongated itself into a fearsome shape that could only be described as a yellowish brown, furry, ape-like creature about nine feet high, with a black wolf-like face and long, protruding canines. Facing Shunya, the creature kept growling at intervals in different pitches and frequencies, and nodding vigorously. Shunya was doing the same thing, growling and nodding back, and it took some time for Thambi to realise that they were communicating with each other......."  

                Attribution-Noncommercial-No Derivative Works 3.0.                        .....JEWEL IN THE LOTUS.......     Like the lotus that grows in water whose leaves and petals remain dry, the yogi derives nourishment from the material world but remains undefiled and untouched by its seductions. In this way, one who wishes to lead a spiritual life can simultaneously perform the role of a responsible member of modern society; neither necessarily compromises the other. With care, practice and knowledge one can reap the benefits of both worlds – to be spiritual you do not have to run away from the world. This book examines the philosophy, spiritual teachings, metaphysics and cultural practices of Hinduism- known collectively as the Sanatana Dharma- and attempts to give one a grasp of its true essence.   *************************************************                            .... SHUNYA A NOVEL ....   "......He was awakened by an unfamiliar growling sound that seemed to come from above the roof. He saw Shunya sitting on his mat and looking up. The growling grew louder and Thambi’s hair stood on end as he saw a round, cannonball-sized blob of brilliant white light coming through the roof. It descended to the ground in front of where Shunya was seated. Then the blob elongated itself into a fearsome shape that could only be described as a yellowish brown, furry, ape-like creature about nine feet high, with a black wolf-like face and long, protruding canines. Facing Shunya, the creature kept growling at intervals in different pitches and frequencies, and nodding vigorously. Shunya was doing the same thing, growling and nodding back, and it took some time for Thambi to realise that they were communicating with each other......."  

Sir William Golding (1911-93), an English novelist achieved literary fame with the publication of his first novel Lord of the Flies (1954). Golding used both of his experiences in writing Lord of the Flies. The Lord of the Flies comes to symbolize the instincts of power and cruelty awakened among the boys. As Lord of the Flies progresses, Golding shows how different boys feel the influences of the instincts of civilization and savagery to different degrees. Here, the conflict might be expressed in a number of ways: civilization vs. savagery, order vs. chaos, reason vs. impulse, law vs. anarchy, or the broader heading of good vs. evil. Throughout the novel, Golding associates the instinct of civilization with good and the instinct of savagery with evil. Like Conrad's work, Golding's novel emphasizes the brutal and violent human impulses that arise in the absence of political order.

345 p. ; 25 cm

345 p. ; 25 cm

This work is dedicated to the study of radiation reaction signatures in the framework of classical and quantum electrodynamics. Since there has been no distinct experimental validation of radiation reaction and its underlying equations so far and its impact is expected to be substantial for the construction of new experimental devices, e.g., quantum x-free electron lasers, a profound understanding of radiation reaction effects is of special interest. Here, we describe how the inclusion of quantum radiation reaction effects changes the dynamics of ultra-relativistic electron beams colliding with intense laser pulses significantly. Thereafter, the angular distribution of emitted radiation is demonstrated to be strongly altered in the quantum framework, if in addition to single photon emission also higher order photon emissions are considered. Furthermore, stimulated Raman scattering of an ultra-intense laser pulse in plasmas is examined and forward Raman scattering is found to be significantly increased by the inclusion of radiation reaction effects in the classical regime. The numerical simulations in this work show the feasibility of an experimental verification of the predicted effects with presently available lasers and electron accelerators.

248 p

LibriVox recording of Aspects of the Novel by E. M. Forster. Read in English by Ciufi Galeazzi This s a series of lectures given at Trinity College by the acclaimed author E.M. Forster (A Passage to India, Howard's End, A Room With a View) . In them, he discusses "both the different ways we can look at a novel and the different ways a novelist can look at his work." The aspects of the novel Forster discusses are the story, people, plot,, fantasy, prophecy and rhythm. While this is a work of academic analysis and not what one expects in a Forster work, the author's wit and voice help make the book very accessible and engaging. - Summary by Ciufi Galeazzi For further information, including links to online text, reader information, RSS feeds, CD cover or other formats (if available), please go to the LibriVox catalog page for this recording. For more free audio books or to become a volunteer reader, visit librivox.org . M4B Audiobook (138MB)

This article is from The Indian Journal of Medical Research , volume 138 . Abstract Susceptibility to autoimmunity is determined by multiple factors. Defining the contribution of the quantitative versus qualitative aspects of antigen-directed immune responses as well as the factors influencing target organ susceptibility is vital to advancing the understanding of the pathogenesis of autoimmunity. In a series of studies, we have addressed these issues using the adjuvant-induced arthritis (AA) model of human rheumatoid arthritis (RA). Lewis rats are susceptible to AA following immunization with heat-killed Mycobacterium tuberculosis H37Ra, whereas Wistar-Kyoto (WKY) rats of the same MHC (major histocompatibility complex) haplotype are resistant. Comparative studies on these and other susceptible/resistant rodent strains have offered interesting insights into differential cytokine responses in the face of comparable T cell proliferative response to the disease relevant antigens. Study of the cytokine kinetics have also permitted validation of the disease-protective versus disease-aggravating effects of specific cytokines by treatment of rats/mice with those cytokines at different phases of the disease. In regard to the target organ attributes, the migration of arthritogenic leukocytes into the joints; the expression of mediators of inflammation, angiogenesis, and tissue damage; the role of vascular permeability; and the characteristics of vascular endothelial cells have been examined. Further, various inhibitors of angiogenesis are effective in suppressing arthritis. Taken together, the differential cytokine responses and unique attributes of the target organ have revealed novel aspects of disease susceptibility and joint damage in AA. The translation of this basic research in animal models to RA patients would not only advance our understanding of the disease process, but also offer novel avenues for immunomodulation of this disease.

This article is from The Indian Journal of Medical Research , volume 138 . Abstract Susceptibility to autoimmunity is determined by multiple factors. Defining the contribution of the quantitative versus qualitative aspects of antigen-directed immune responses as well as the factors influencing target organ susceptibility is vital to advancing the understanding of the pathogenesis of autoimmunity. In a series of studies, we have addressed these issues using the adjuvant-induced arthritis (AA) model of human rheumatoid arthritis (RA). Lewis rats are susceptible to AA following immunization with heat-killed Mycobacterium tuberculosis H37Ra, whereas Wistar-Kyoto (WKY) rats of the same MHC (major histocompatibility complex) haplotype are resistant. Comparative studies on these and other susceptible/resistant rodent strains have offered interesting insights into differential cytokine responses in the face of comparable T cell proliferative response to the disease relevant antigens. Study of the cytokine kinetics have also permitted validation of the disease-protective versus disease-aggravating effects of specific cytokines by treatment of rats/mice with those cytokines at different phases of the disease. In regard to the target organ attributes, the migration of arthritogenic leukocytes into the joints; the expression of mediators of inflammation, angiogenesis, and tissue damage; the role of vascular permeability; and the characteristics of vascular endothelial cells have been examined. Further, various inhibitors of angiogenesis are effective in suppressing arthritis. Taken together, the differential cytokine responses and unique attributes of the target organ have revealed novel aspects of disease susceptibility and joint damage in AA. The translation of this basic research in animal models to RA patients would not only advance our understanding of the disease process, but also offer novel avenues for immunomodulation of this disease.

This article is from The Indian Journal of Medical Research , volume 138 . Abstract Susceptibility to autoimmunity is determined by multiple factors. Defining the contribution of the quantitative versus qualitative aspects of antigen-directed immune responses as well as the factors influencing target organ susceptibility is vital to advancing the understanding of the pathogenesis of autoimmunity. In a series of studies, we have addressed these issues using the adjuvant-induced arthritis (AA) model of human rheumatoid arthritis (RA). Lewis rats are susceptible to AA following immunization with heat-killed Mycobacterium tuberculosis H37Ra, whereas Wistar-Kyoto (WKY) rats of the same MHC (major histocompatibility complex) haplotype are resistant. Comparative studies on these and other susceptible/resistant rodent strains have offered interesting insights into differential cytokine responses in the face of comparable T cell proliferative response to the disease relevant antigens. Study of the cytokine kinetics have also permitted validation of the disease-protective versus disease-aggravating effects of specific cytokines by treatment of rats/mice with those cytokines at different phases of the disease. In regard to the target organ attributes, the migration of arthritogenic leukocytes into the joints; the expression of mediators of inflammation, angiogenesis, and tissue damage; the role of vascular permeability; and the characteristics of vascular endothelial cells have been examined. Further, various inhibitors of angiogenesis are effective in suppressing arthritis. Taken together, the differential cytokine responses and unique attributes of the target organ have revealed novel aspects of disease susceptibility and joint damage in AA. The translation of this basic research in animal models to RA patients would not only advance our understanding of the disease process, but also offer novel avenues for immunomodulation of this disease.

This article is from The Indian Journal of Medical Research , volume 138 . Abstract Susceptibility to autoimmunity is determined by multiple factors. Defining the contribution of the quantitative versus qualitative aspects of antigen-directed immune responses as well as the factors influencing target organ susceptibility is vital to advancing the understanding of the pathogenesis of autoimmunity. In a series of studies, we have addressed these issues using the adjuvant-induced arthritis (AA) model of human rheumatoid arthritis (RA). Lewis rats are susceptible to AA following immunization with heat-killed Mycobacterium tuberculosis H37Ra, whereas Wistar-Kyoto (WKY) rats of the same MHC (major histocompatibility complex) haplotype are resistant. Comparative studies on these and other susceptible/resistant rodent strains have offered interesting insights into differential cytokine responses in the face of comparable T cell proliferative response to the disease relevant antigens. Study of the cytokine kinetics have also permitted validation of the disease-protective versus disease-aggravating effects of specific cytokines by treatment of rats/mice with those cytokines at different phases of the disease. In regard to the target organ attributes, the migration of arthritogenic leukocytes into the joints; the expression of mediators of inflammation, angiogenesis, and tissue damage; the role of vascular permeability; and the characteristics of vascular endothelial cells have been examined. Further, various inhibitors of angiogenesis are effective in suppressing arthritis. Taken together, the differential cytokine responses and unique attributes of the target organ have revealed novel aspects of disease susceptibility and joint damage in AA. The translation of this basic research in animal models to RA patients would not only advance our understanding of the disease process, but also offer novel avenues for immunomodulation of this disease.

This article is from The Indian Journal of Medical Research , volume 138 . Abstract Susceptibility to autoimmunity is determined by multiple factors. Defining the contribution of the quantitative versus qualitative aspects of antigen-directed immune responses as well as the factors influencing target organ susceptibility is vital to advancing the understanding of the pathogenesis of autoimmunity. In a series of studies, we have addressed these issues using the adjuvant-induced arthritis (AA) model of human rheumatoid arthritis (RA). Lewis rats are susceptible to AA following immunization with heat-killed Mycobacterium tuberculosis H37Ra, whereas Wistar-Kyoto (WKY) rats of the same MHC (major histocompatibility complex) haplotype are resistant. Comparative studies on these and other susceptible/resistant rodent strains have offered interesting insights into differential cytokine responses in the face of comparable T cell proliferative response to the disease relevant antigens. Study of the cytokine kinetics have also permitted validation of the disease-protective versus disease-aggravating effects of specific cytokines by treatment of rats/mice with those cytokines at different phases of the disease. In regard to the target organ attributes, the migration of arthritogenic leukocytes into the joints; the expression of mediators of inflammation, angiogenesis, and tissue damage; the role of vascular permeability; and the characteristics of vascular endothelial cells have been examined. Further, various inhibitors of angiogenesis are effective in suppressing arthritis. Taken together, the differential cytokine responses and unique attributes of the target organ have revealed novel aspects of disease susceptibility and joint damage in AA. The translation of this basic research in animal models to RA patients would not only advance our understanding of the disease process, but also offer novel avenues for immunomodulation of this disease.

This article is from BMC Plant Biology , volume 13 . Abstract Background: Glutamine Synthetase (GS, EC 6.3.1.2) is a central enzyme in nitrogen metabolism, and a key component of nitrogen use efficiency (NUE) and plant yield and thus it is extremely important to understand how it is regulated in plants. Medicago truncatula provides an excellent model system to study GS, as it contain a very simple GS gene family comprising only four expressed genes, MtGS1a and MtGS1b encoding cytosolic polypeptides, and MtGS2a and MtGS2b encoding plastid-located enzymes. To identify new regulatory mechanisms controlling GS activity, we performed a detailed expression analysis of the entire GS gene family of M. truncatula in the major organs of the plant, over a time course of nodule or seed development and during a diurnal cycle. Results: Individual GS transcripts were quantified by qRT-PCR, and GS polypeptides and holoenzymes were evaluated by western blot and in-gel activity under native electrophoresis. These studies revealed that all four GS genes are differentially regulated in each organ of the plant, in a developmental manner, and identified new regulatory controls, which appear to be specific to certain metabolic contexts. Studies of the protein profiles showed that the GS polypeptides assemble into organ-specific protein complexes and suffer organ-specific post-translational modifications under defined physiological conditions. Our studies also reveal that GS expression and activity are modulated during a diurnal cycle. The biochemical properties of the four isoenzymes were determined and are discussed in relation to their function in the plant. Conclusions: This work provides a comprehensive overview of GS expression and regulation in the model legume M. truncatula, contributing to a better understanding of the specific function of individual isoenzymes and to the identification of novel organ-specific post-translational mechanisms of GS regulation. We demonstrate that the GS proteins are modified and/or integrated into protein-complexes that assemble into a specific composition in particular organs of the plant. Taken together, the results presented here open new avenues to explore the regulatory mechanisms controlling GS activity in plants, a subject of major importance due to the crucial importance of the enzyme for plant growth and productivity.

e-m-forster_aspects-of-the-novel

This article is from International Journal of Molecular Sciences , volume 15 . Abstract Hepatocellular carcinoma (HCC) is a prevalent primary liver cancer that is derived from hepatocytes and is characterised by high mortality rate and poor prognosis. While HCC is driven by cumulative changes in the hepatocyte genome, it is increasingly recognised that the liver microenvironment plays a pivotal role in HCC propensity, progression and treatment response. The microenvironmental stimuli that have been recognised as being involved in HCC pathogenesis are diverse and include intrahepatic cell subpopulations, such as immune and stellate cells, pathogens, such as hepatitis viruses, and non-cellular factors, such as abnormal extracellular matrix (ECM) and tissue hypoxia. Recently, a number of novel environmental influences have been shown to have an equally dramatic, but previously unrecognized, role in HCC progression. Novel aspects, including diet, gastrointestinal tract (GIT) microflora and circulating microvesicles, are now being recognized as increasingly important in HCC pathogenesis. This review will outline aspects of the HCC microenvironment, including the potential role of GIT microflora and microvesicles, in providing new insights into tumourigenesis and identifying potential novel targets in the treatment of HCC.

This article is from International Journal of Molecular Sciences , volume 15 . Abstract Hepatocellular carcinoma (HCC) is a prevalent primary liver cancer that is derived from hepatocytes and is characterised by high mortality rate and poor prognosis. While HCC is driven by cumulative changes in the hepatocyte genome, it is increasingly recognised that the liver microenvironment plays a pivotal role in HCC propensity, progression and treatment response. The microenvironmental stimuli that have been recognised as being involved in HCC pathogenesis are diverse and include intrahepatic cell subpopulations, such as immune and stellate cells, pathogens, such as hepatitis viruses, and non-cellular factors, such as abnormal extracellular matrix (ECM) and tissue hypoxia. Recently, a number of novel environmental influences have been shown to have an equally dramatic, but previously unrecognized, role in HCC progression. Novel aspects, including diet, gastrointestinal tract (GIT) microflora and circulating microvesicles, are now being recognized as increasingly important in HCC pathogenesis. This review will outline aspects of the HCC microenvironment, including the potential role of GIT microflora and microvesicles, in providing new insights into tumourigenesis and identifying potential novel targets in the treatment of HCC.

This article is from International Journal of Molecular Sciences , volume 15 . Abstract Hepatocellular carcinoma (HCC) is a prevalent primary liver cancer that is derived from hepatocytes and is characterised by high mortality rate and poor prognosis. While HCC is driven by cumulative changes in the hepatocyte genome, it is increasingly recognised that the liver microenvironment plays a pivotal role in HCC propensity, progression and treatment response. The microenvironmental stimuli that have been recognised as being involved in HCC pathogenesis are diverse and include intrahepatic cell subpopulations, such as immune and stellate cells, pathogens, such as hepatitis viruses, and non-cellular factors, such as abnormal extracellular matrix (ECM) and tissue hypoxia. Recently, a number of novel environmental influences have been shown to have an equally dramatic, but previously unrecognized, role in HCC progression. Novel aspects, including diet, gastrointestinal tract (GIT) microflora and circulating microvesicles, are now being recognized as increasingly important in HCC pathogenesis. This review will outline aspects of the HCC microenvironment, including the potential role of GIT microflora and microvesicles, in providing new insights into tumourigenesis and identifying potential novel targets in the treatment of HCC.

1Room with a View

By E. M. Forster

When Lucy Honeychurch travels to Italy with her cousin, she meets George Emerson, a bohemian and an atheist who falls in love with her. Upon her return to England, she is forced to choose between free-spirited George and her more conventional fiancé, Cecil Vyse. The story is both a romance and a critique of English society at the beginning of the 20th century. (Summary from Wikipedia)

2Howards End

By E. M. Forster

The book is about three families in England at the beginning of the twentieth century. The three families represent different gradations of the Edwardian middle class: the Wilcoxes, who are rich capitalists with a fortune made in the Colonies; the half-German Schlegel siblings (Margaret, Tibby, and Helen), who represent the intellectual bourgeoisie and have a lot in common with the real-life Bloomsbury Group; and the Basts, a couple who are struggling members of the lower-middle class. The Schlegel sisters try to help the poor Basts and try to make the Wilcoxes less prejudiced. The motto of the book is "Only connect..."

3Howards End (version 2)

By E. M. Forster

The Schlegels frequently encounter the Wilcoxes. The youngest, Helen, is rejected by the younger Wilcox brother, Paul. The eldest, Margaret, becomes friends with his mother Ruth Wilcox. Ruth's most prized personal possession is her family house at Howards End. She wishes that Margaret could live there, as she feels that it might be in good hands with her. Ruth's own husband and children do not value the house and its rich history, because such abstractions, while being very dear to Margaret, are lost to them. As she is terminally ill, and Margaret and her family are about to be evicted from their London home by a developer, Ruth bequeaths the cottage to Margaret in a handwritten note found among her effects when she dies, causing great consternation among the Wilcoxes. Mrs Wilcox's widowed husband Henry and his children burn the note without telling Margaret about her inheritance. However, over the course of several years, Margaret becomes friends with Henry Wilcox and eventually marries him. The more free-spirited Margaret tries to get Henry to open up more, to little effect. Henry's elder son Charles and his wife try to keep Margaret from taking possession of Howards End. (Summary from Wikipedia)

The Machine Stops is a short science fiction story. It describes a world in which almost all humans have lost the ability to live on the surface of the Earth. Each individual lives in isolation in a 'cell', with all bodily and spiritual needs met by the omnipotent, global Machine. Most humans welcome this development, as they are skeptical and fearful of first-hand experience. People forget that humans created the Machine, and treat it as a mystical entity whose needs supersede their own. Those who do not accept the deity of the Machine are viewed as 'unmechanical' and are threatened with "Homelessness". Eventually, the Machine apocalyptically collapses, and the civilization of the Machine comes to an end. (Wikipedia)<br /><br />Comment by book coordinator: A condensed rapidfire of details and ideas imagining a dystopian world. Good thing he made it a short story. And the world he describes feels so appalling, although we are good on the way to be where Forster imagined us - shocker. So imaginative for 1909! Staying at home with the telly and internet and instant messaging and videoconferencing, google and pizza delivery and all flats and all cities look alike. And the loss of Patience! Damn this is good and so true - with one big exception the many buttons for all the machines functions. But how would Forster know of digital interfaces? That would have been too much to foresee.

5Where Angels Fear to Tread

By E. M. Forster

On a journey to Tuscany with her young friend and traveling companion Caroline Abbott, widowed Lilia Herriton falls in love with both Italy and a handsome Italian much younger than herself, and decides to stay. Furious, her dead husband's family send Lilia's brother-in-law to Italy to prevent a misalliance, but he arrives too late. Lilia marries the Italian and in due course becomes pregnant again. When she dies giving birth to her child, the Herritons consider it both their right and their duty to travel to Monteriano to obtain custody of the infant so that he can be raised as an Englishman. (Summary from Wikipedia)

6Longest Journey

By E. M. Forster

Frederick Elliot is a student at early 20th century Cambridge, a university that seems like paradise to him, amongst bright if cynical companions, when he receives a visit from two friends, an engaged young woman, Agnes Pembroke, and her older brother, Herbert. The Pembrokes are Rickie’s only friends from home. An orphan who grew up living with cousins, he was sent to a public (boarding) school where he was shunned and bullied because of his lame foot, an inherited weakness, and frail body. Agnes, as it happens, is engaged to Gerald, now in the army, who was one of the sturdy youths who bullied Rickie at school. Rickie is not brilliant at argument, but he is intensely responsive to poetry and art, and is accepted within a circle of philosophical and intellectual fellow-students led by a brilliant but especially cynical aspiring philosopher, Stuart Ansell, who refuses, when he is introduced to her, even to acknowledge that Agnes exists. (from Wikipedia)

Published in 1909, this science fiction short story takes place in a future where mankind, seemingly no longer able to survive on earth's surface, exists in a vast underground civilization known as "The Machine". Each individual lives in an isolated, fully-automated cell-like room, connected to global information and communication systems, but cut off from all direct experience. The narrative focuses on Vashti, an "advanced" mother whose total dependence upon The Machine has led her (like most others) to increasingly reverence and even worship it; and her "untechnological" son, Kuno, who has begun to deny The Machine's omnipotence and even seeks to escape if possible. Kuno's radical views are validated as the The Machine's systems begin to malfunction and eventually fail completely.<br /><br />The story has proved to be far ahead of its time, with remarkably accurate predictions of modern technologies, and paints a chilling picture of over-dependence on them. This recording marks the 100th anniversary of the original publishing. (Summary by Jerome Lawsen)

8Room with a View (version 2)

By E. M. Forster

The 1908 novel A Room With a View is the story of Lucy Honeychurch, a young English girl traveling to Italy for the first time. While staying in Florence, Lucy meets the unconventional George Emerson, with whom she shares a single passionate kiss, much to the horror of her chaperone, her spinsterish cousin Charlotte. Back in England, Lucy finds she must choose between George and her rather stuffy fiance Cecil Vyse. Forster's wonderfully comic romance satirizes turn-of-the-century English culture (as did his other major novel of the period, Howards End). (Summary by Elizabeth Klett)

"The Machine Stops" is a science fiction short story by E. M. Forster. After initial publication in The Oxford and Cambridge Review (November 1909), the story was republished in Forster's The Eternal Moment and Other Stories in 1928. After being voted one of the best novellas up to 1965, it was included that same year in the populist anthology Modern Short Stories. The story describes a world in which most of the human population has lost the ability to live on the surface of the Earth. Each individual now lives in isolation below ground in a standard 'cell', with all bodily and spiritual needs met by the omnipotent, global Machine. ( Summary by Wikipedia )

10Room with a View (version 3 dramatic reading)

By E. M. Forster

A Room with a View is a 1908 novel by English writer E. M. Forster, about a young woman in the repressed culture of Edwardian era England. Set in Italy and England, the story is both a romance and a critique of English society at the beginning of the 20th century. (Summary by Wikipedia)<br><br><strong>Cast</strong>:<br>Lucy Honeychurch/Narrator: <a href="http://librivox.org/reader/3536">Arielle Lipshaw</a><br>Charlotte Bartlett: <a href="http://librivox.org/reader/1259">Elizabeth Klett</a><br>Mr. Emerson: <a href="http://librivox.org/reader/7150">asterix</a><br>George Emerson: <a href="http://librivox.org/reader/7867">nomorejeffs</a><br>Mr. Beebe: <a href="http://librivox.org/reader/3912">Bob Neufeld</a><br>Miss Eleanor Lavish: <a href="http://librivox.org/reader/4145">Patti Cunningham</a><br>Miss Theresa Alan: <a href="http://librivox.org/reader/5471">ElleyKat</a><br>Miss Catharine Alan: <a href="http://librivox.org/reader/7766">Maryanka</a><br>Italian Lady/Persephone/Maid: <a href="http://librivox.org/reader/7679">Libby Gohn</a><br>Mr. Eager/Powell: <a href="http://librivox.org/reader/4267">Ric F</a><br>Vicar/Sir Harry Otway/Phaethon/Freddy Honeychurch: <a href="http://librivox.org/reader/8169">tovarisch</a><br>Mrs. Honeychurch: <a href="http://librivox.org/reader/7138">CaprishaPage</a><br>Cecil Vyse: <a href="http://librivox.org/reader/4535">Brett W. Downey</a><br>Mrs. Vyse: <a href="http://librivox.org/reader/7925">Etel Buss</a><br>Minnie Beebe: <a href="http://librivox.org/reader/7315">Charlotte Duckett</a><br><br><strong>Audio edited by:</strong> Arielle Lipshaw

"The Machine Stops" is a science fiction story by E. M. Forster. After initial publication in 1909 the story was republished in Forster's The Eternal Moment and Other Stories in 1928. After being voted one of the best novellas up to 1965, it was included that same year in the populist anthology Modern Short Stories. In 1973 it was also included in The Science Fiction Hall of Fame, Volume Two. The story is particularly notable for predicting new technologies such as instant messaging and the Internet. In the preface to his Collected Short Stories (1947), Forster wrote that "The Machine Stops is a reaction to one of the earlier heavens of H. G. Wells." Although not all Wells's stories were optimistic about the future, this implies Forster was concerned about human dependence on technology. - Summary by Wikipedia

12Howards End (version 3)

By E. M. Forster

Considered Forster's masterpiece and one of the best books of the 20th century, Howards End tackles social conventions of the Edwardian era. The story focuses on three families in England at the beginning of the 20th century: the Wilcoxes, rich capitalists with a fortune made in the colonies; the half-German Schlegel siblings (Margaret, Helen, and Tibby), whose cultural pursuits have much in common with the Bloomsbury Group; and the Basts, an impoverished young couple from a lower-class background. The idealistic, intelligent Schlegel sisters seek to help the struggling Basts and to rid the Wilcoxes of some of their deep-seated social and economic prejudices. - Summary by Lynne Thompson

13Passage to India (Dramatic Reading)

By E. M. Forster

A Passage to India (1924) is a novel by English author E. M. Forster set against the backdrop of the British Raj and the Indian independence movement in the 1920s. The story revolves around four characters: Dr. Aziz, his British friend Mr. Cyril Fielding, Mrs. Moore, and Miss Adela Quested. During a trip to the fictitious Marabar Caves (modeled on the Barabar Caves of Bihar), Adela thinks she finds herself alone with Dr. Aziz in one of the caves (when in fact he is in an entirely different cave), and subsequently panics and flees; it is assumed that Dr. Aziz has attempted to assault her. Aziz's trial, and its run-up and aftermath, bring to a boil the common racial tensions and prejudices between Indians and the British who rule India.

14Passage to India

By E. M. Forster

E. M. Forster’s <i>A Passage to India</i> (1924) is widely acclaimed as one of the hundred best literary works of 20th century. <i>Time</i> magazine rates it among the top 100 English-language novels of all time.<br><br> <i>A Passage to India</i> is set at the moment when the lasting supremacy of the British Raj could no longer be taken for granted. Imperial power had been effectively supported by old and deep-seated religious and cultural conflicts between India’s Hindu and Muslim populations, which divided and sapped the local powers ultimately needed to overthrew imperial rule in 1947. Forster illustrates how this rift begins to be overshadowed by the increasing resistance of all Indians to the extreme racism, oppression and socio-political mismanagement of British rule.<br><br> The work is perhaps best known for his brilliant development of the relationships between his characters, which are fraught by a wide range of precarious cultural, social, political and economic dualisms: e.g., Occident / Orient; imperialist / colonial; men / women. He carries the idea expressed in his famous words “only connect” (from Howards End) to its limits, examining the difficulties – often the inherent impossibility – of “connection” across racial, sexual, religious and social divides. - Summary by Kirsten Wever

15Celestial Omnibus, and Other Stories

By E. M. Forster

With twenty Nobel Prize nominations to his credit, E. M. Forster may reasonably be considered one of the best writers of the 20th century – perhaps of all time. He is best known for his 1924 novel <a href="https://librivox.org/a-passage-to-india-by-e-m-forster/">A Passage to India</a>. But almost all his writings met with rapid critical, popular and international success.<br><br> Forster’s world-view was exceptionally broad – even multi-cultural – as expressed in the humanism characterizing all his works, in the wide-ranging social criticism of Howard’s End, and in the spiritual and mystical themes for which A Passage to India is famous, and which also underlie the stories collected in The Celestial Omnibus. - Summary by Kirsten Wever

16Aspects of the Novel

By E. M. Forster

This s a series of lectures given at Trinity College by the acclaimed author E.M. Forster (A Passage to India, Howard's End, A Room With a View) . In them, he discusses "both the different ways we can look at a novel and the different ways a novelist can look at his work." The aspects of the novel Forster discusses are the story, people, plot,, fantasy, prophecy and rhythm. While this is a work of academic analysis and not what one expects in a Forster work, the author's wit and voice help make the book very accessible and engaging. - Summary by Ciufi Galeazzi