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The integration of Artificial Intelligence (AI) and the Internet of Things (IoT s ) in the healthcare sector has opened up new possibilities for improving health services within innovative urban settings. This article provides a comprehensive overview of AI - IoT s systems aimed at managing healthcare data in smart cities. Key components such as predictive health analytics, remote patient monitoring, and the interoperability of healthcare systems are explored. The impact of these technologies on the management o f chronic illnesses, telemedicine, and smart city infrastructure will be analyzed, considering important aspects related to privacy and ethical concerns. Our findings suggest that AI - IoT s systems hold the promise of improving real - time patient monitoring and AI - driven diagnostic capabilities, thereby significantly transforming the healthcare landscape .