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A Refined Model For The Tsg 6 Link Module In Complex With Hyaluronan%3a Use Of Defined Oligosaccharides To Probe Structure And Function%2b. by Higman%2c Victoria A.
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1A Refined Model For The TSG-6 Link Module In Complex With Hyaluronan: USE OF DEFINED OLIGOSACCHARIDES TO PROBE STRUCTURE AND FUNCTION*.
By Higman, Victoria A., Briggs, David C., Mahoney, David J., Blundell, Charles D., Sattelle, Benedict M., Dyer, Douglas P., Green, Dixy E., DeAngelis, Paul L., Almond, Andrew, Milner, Caroline M. and Day, Anthony J.
This article is from The Journal of Biological Chemistry , volume 289 . Abstract Background: The polysaccharide hyaluronan is organized through interactions with the protein TSG-6 during inflammation and ovulation.Results: NMR spectroscopy on TSG-6 in the presence of defined sugars provided restraints that allowed modeling of a refined hyaluronan/TSG-6 complex.Conclusion: TSG-6 binding causes bending of hyaluronan that explains its condensation of this polysaccharide.Significance: This provides novel structural insights into protein-hyaluronan interactions.
“A Refined Model For The TSG-6 Link Module In Complex With Hyaluronan: USE OF DEFINED OLIGOSACCHARIDES TO PROBE STRUCTURE AND FUNCTION*.” Metadata:
- Title: ➤ A Refined Model For The TSG-6 Link Module In Complex With Hyaluronan: USE OF DEFINED OLIGOSACCHARIDES TO PROBE STRUCTURE AND FUNCTION*.
- Authors: ➤ Higman, Victoria A.Briggs, David C.Mahoney, David J.Blundell, Charles D.Sattelle, Benedict M.Dyer, Douglas P.Green, Dixy E.DeAngelis, Paul L.Almond, AndrewMilner, Caroline M.Day, Anthony J.
- Language: English
Edition Identifiers:
- Internet Archive ID: pubmed-PMC3937638
Downloads Information:
The book is available for download in "texts" format, the size of the file-s is: 1.66 Mbs, the file-s for this book were downloaded 25 times, the file-s went public at Thu Oct 23 2014.
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