"Does The Phaco-TIp Position During Clear Corneal Phacoemulsification Surgery Adversely Affect Corneal Endothelium? TIPS Study Protocol For A Randomised, Triple-masked, Parallel-group Trial Of Bevel-up Versus Bevel-down Phacoemulsification" - Information and Links:

Does The Phaco-TIp Position During Clear Corneal Phacoemulsification Surgery Adversely Affect Corneal Endothelium? TIPS Study Protocol For A Randomised, Triple-masked, Parallel-group Trial Of Bevel-up Versus Bevel-down Phacoemulsification - Info and Reading Options


“Does The Phaco-TIp Position During Clear Corneal Phacoemulsification Surgery Adversely Affect Corneal Endothelium? TIPS Study Protocol For A Randomised, Triple-masked, Parallel-group Trial Of Bevel-up Versus Bevel-down Phacoemulsification” Metadata:

  • Title: ➤  Does The Phaco-TIp Position During Clear Corneal Phacoemulsification Surgery Adversely Affect Corneal Endothelium? TIPS Study Protocol For A Randomised, Triple-masked, Parallel-group Trial Of Bevel-up Versus Bevel-down Phacoemulsification
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  • Internet Archive ID: osf-registrations-5ys6w-v1

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"Does The Phaco-TIp Position During Clear Corneal Phacoemulsification Surgery Adversely Affect Corneal Endothelium? TIPS Study Protocol For A Randomised, Triple-masked, Parallel-group Trial Of Bevel-up Versus Bevel-down Phacoemulsification" Description:

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Background: Globally, at least 30 million cataract surgeries are required annually to prevent cataract-related blindness. Corneal endothelial decompensation is one of the most common causes of poor visual outcome following cataract surgery, particularly in those with predisposing factors. The increasing ageing population and reduced visual impairment threshold for cataract surgery have resulted in rising cataract surgical rates and hence, an increase in corneal endothelial decompensation is expected. The role of phaco-tip position on corneal endothelial damage is ambiguous. Previous studies have reported contradictory results and were also underpowered to detect a significant difference due to small sample sizes. With no consensus regarding the most cornea-friendly phaco-tip position (bevel-up versus bevel-down) during phacoemulsification, we propose a randomised clinical trial with a robust design using direct chop phaco-technique. Objective: To compare the effect of phaco-tip position (bevel-up vs. bevel-down) on corneal endothelial cell count during phacoemulsification Methods: A randomised, multicentre, parallel-group, triple-masked (participant, outcome assessor, and statistician) trial with 1:1 allocation ratio is proposed. By adopting stratified randomisation (according to cataract grade), we will randomly allocate 480 patients aged >18 years with immature cataract into bevel-up and bevel-down groups at two centres. History of significant ocular trauma, previous intraocular surgery, shallow anterior chamber, low endothelial cell count, pseudoexfoliation syndrome, intraocular inflammation, and corneal endothelial dystrophy are the key exclusion criteria. Outcomes: Primary- postoperative endothelial cell count at one month. Secondary- central corneal thickness on postoperative days 1, 15, and 30, and intraoperative complications.

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