Combinatorial Library Design and Evaluation
Principles, Software, Tools, and Applications in Drug Discovery
By Arup Ghose and Vellerkad Viswanadhan
"Combinatorial Library Design and Evaluation" was published by Taylor & Francis Group in 2001 - Milton, it has 648 pages and the language of the book is English.
“Combinatorial Library Design and Evaluation” Metadata:
- Title: ➤ Combinatorial Library Design and Evaluation
- Authors: Arup GhoseVellerkad Viswanadhan
- Language: English
- Number of Pages: 648
- Publisher: Taylor & Francis Group
- Publish Date: 2001
- Publish Location: Milton
“Combinatorial Library Design and Evaluation” Subjects and Themes:
- Subjects: ➤ Drugs - Combinatorial chemistry - Computer simulation - Design - Medicaments - Simulation par ordinateur - Drug Design - Combinatorial Chemistry Techniques - Computer Simulation - Chimie combinatoire - Drugs, design - Pharmaceutical Chemistry
Edition Identifiers:
- The Open Library ID: OL33513038M - OL19804851W
- ISBN-13: 9781482270761
- All ISBNs: 9781482270761
AI-generated Review of “Combinatorial Library Design and Evaluation”:
"Combinatorial Library Design and Evaluation" Description:
Open Data:
Cover -- Half Title -- Title Page -- Copyright Page -- Preface -- Contents -- Contributors -- PART I: INTRODUCTION -- 1: Library Design Concepts and Implementation Strategies -- I. INTRODUCTION -- A. Defining the Goal -- II. HIGH THROUGHPUT SYNTHESIS TECHNIQUES -- A. Solid Phase Organic Synthesis (SPOS) -- B. Solution Phase Synthesis (41,42) -- Ill. LIBRARY CONSTRUCTION STRATEGIES -- A. Parallel Synthesis -- B. Pooled Synthesis -- IV. COMPOUND DESIGN WITHIN COMBINATORIAL LIBRARIES -- A. Library Diversity -- B. Controlling Molecular Properties -- V. LOOKING FOR LEADS: DISCOVERY LIBRARIES -- A. Synthesis of Ollgomers -- B. Efficient Construction -- C. Branching Strategies -- VI. LEVERAGING KNOWLEDGE: TARGETED LIBRARIES -- VII. MOVING BEYOND AFFINITY: OPTIMIZATION LIBRARIES -- A. Improving Molecular Properties -- VIII. CONCLUSION -- REFERENCES -- PART II: DESIGN PRINCIPLES -- 2: The Fundamentals of Pharmacophore Modeling in Combinatorial Chemistry -- I. INTRODUCTION -- II. THE TRADITIONAL APPROACH TO IDENTIFYING A PHARMACOPHORIC GROUP -- Ill. A GENERAL CLASSIFICATION OF PHARMACOPHORIC GROUPS -- IV. IDENTIFICATION OF PHARMACOPHORIC GROUPS -- V. DETERMINATION OF PHARMACOPHORIC GEOMETRY -- VI. MOLECULAR SIMILARITY METHODS AS AN ALTERNATIVE TO PHARMACOPHORE MODELING -- VII. PROTEIN BINDING SITE FOR THE EXPLORATION OF PHARMACOPHORIC GROUPS AND GEOMETRY -- VIII. GEOMETRY OF NATURAL SUBSTRATES, AGONISTS, AND ANTAGONISTS AS A SOURCE OF PHARMACOPHORIC HYPOTHESIS -- IX. THE VARIOUS EXPERIMENTAL APPROACHES TO VERIFY A PHARMACOPHORE MODEL -- X. USE OF THE PHARMACOPHORE MODEL IN MEDICINAL CHEMISTRY -- A. Search for Pharmacophorlc Groups -- B. Search for the Pharmacophores Satisfying the Geometric Requirements -- C. Search for the Proper Scaffold to Hold the Pharmacophoric Groups -- XI. USE OF PHARMACOPHORES IN COMBINATORIAL LIBRARY DESIGN
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